Melanoma with halo

Rubegni, Pietro; Nami, Niccolò; Risulo, Massimiliano; Tataranno, Domenico R.; Fimiani, Michele

doi:10.1111/j.1365-2230.2008.03030.x

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…For this reason and because melanoma with halo-like depigmentation, although rare, additionally exhibits melanoma-specific dermoscopic criteria, the authors concluded that the role of digital dermoscopic follow-up in the diagnosis of halo nevi is nonsignificant. Regarding patient age, Rubegni et al established that patients who have a halo associated with melanoma are older than patients who have a halo nevus associated with benign melanocytic nevi [11]. As our patients are only 21 and 43 years old, we cannot confirm this point of view, and we stress that young age cannot definitively classify the halo nevus as benign.…”

Section: Discussioncontrasting

confidence: 64%

Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi

Schrijver

Théate

Vanhooteghem

2021

Case Reports in Dermatological Medicine

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Background. Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Case presentation. This report of two young patients indicates the importance of obtaining a detailed history to detect warning signs such as itching, pain, spontaneous bleeding, and previous alterations according to the patient, including a previously totally black colour in an already fully regressed melanoma. Conclusions. The risk of a halo nevus being malignant is higher if there is only one unique halo nevus and no personal or familial history of vitiligo. We postulate that a regressing atypical nevus or a regressing melanoma may be induced by an immunologic reaction as halo nevus type of clinical picture.

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Section: Discussioncontrasting

confidence: 64%

Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi

Schrijver

Théate

Vanhooteghem

2021

Case Reports in Dermatological Medicine

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“…A depigmented halo (=leukoderma acquisitum centrifuguum) around a melanoma is extremely rare and has a more asymmetrical shape than in halo nevi. Usually, a melanoma with a surrounding halo regresses completely, but local and distant metastases may occur (Rubegni et al, 2009). Remarkably, regression is more common in adult patients (Requena et al, 2009).…”

Section: Regression In Melanomamentioning

confidence: 99%

Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy

Speeckaert

Geel

Vermaelen

et al. 2010

Pigment Cell Melanoma Res

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SummarySpontaneous regression of benign and malignant melanocytic lesions can be a visible sign of immunosurveillance. In this review, we discuss different immune reactions against melanocytic lesions: halo nevus, Meyerson's nevus, regression in melanoma and melanoma-associated depigmentation. These entities present with particular clinical aspects, histology and evolution. In all entities, a melanocyte-specific T-cell reaction has been assumed but a different degree of melanocyte destruction is present. A focus on the immune responses in melanocytic lesions reveals several aspects of an adequate skin immunity and may help to identify the key points in the immune destruction of melanocytes. These insights can add to the knowledge of how to optimize immunotherapeutic strategies in melanoma.

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“…Histological examination shows spongiotic dermatitis 2 . Both processes are thought to reflect an immunological T‐cell response directed against some melanocyte antigens expressed in the affected naevi, and both have been described in association with concomitant malignant melanoma 3,4 . In our patient, the perinaevic modifications were limited to hypermelanosis of the epidermal basal layer, without any anomaly suggestive of a pre‐existent inflammatory process (i.e.…”

mentioning

confidence: 61%

Eruptive pigmentation around naevi and seborrhoeic keratoses in a patient with stage III melanoma: hyperpigmented halo or ‘Nottus’ phenomenon

2013

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Melanoma with halo

Cited by 14 publications

References 6 publications

Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi

Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi

Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy

Eruptive pigmentation around naevi and seborrhoeic keratoses in a patient with stage III melanoma: hyperpigmented halo or ‘Nottus’ phenomenon

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