Melanoma Within a Southwestern Hispanic Population

Black, William C.

doi:10.1001/archderm.1987.01660340093027

Cited by 43 publications

(9 citation statements)

References 22 publications

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“…Hispanics are now the largest ethnic minority in the United States, comprising 17.8% of the population . Though data regarding stage at diagnosis and outcomes by ethnic group in pediatric melanoma are extremely limited, several studies inclusive of adults have reported that minorities including Hispanics with melanoma are more likely to present with regional or distant disease, further underscoring the need for public health strategies directly targeting Hispanics.…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma incidence among children and adolescents in Texas and SEER 13, 1995–2013

Danysh

Navai

Scheurer

et al. 2019

Pediatric Blood & Cancer

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Background Epidemiological knowledge and predictors of melanoma among children and adolescents in multiethnic populations are limited. Procedure Using data from the Texas Cancer Registry (TCR) and the Surveillance, Epidemiology, and End Results (SEER) 13 database, we identified incident melanoma cases diagnosed at 0–20 years old during 1995–2013 in Texas and the United States, respectively. Using negative binomial regression, associations between demographic factors and melanoma incidence rates (IR) were evaluated by calculating incidence rate ratios (IRR) and 95% confidence intervals (CI). Annual percent change in IRs was assessed with joinpoint regression. Results Overall, the melanoma IR was 4.16 (TCR, n = 634) and 4.84 (SEER, n = 1260) per million. Females, adolescents, non‐Hispanic (NH) whites, and Hispanics had higher IRs compared with other groups (P < 0.05). In adjusted analyses, Hispanics had a higher incidence of melanoma than NH non‐whites (Texas IRR = 2.17; 95% CI, 1.30–3.61; SEER IRR = 2.88; 95% CI, 1.97–4.21). In Texas, NH whites with melanoma were more likely to live in low poverty areas, whereas the opposite trend was observed in Hispanics. Melanoma IRs increased throughout 1995–2004 followed by an average annual decrease of 7.6% (95% CI, −12.6%, −2.2%) in Texas and 6.0% (95% CI, −8.5%, −3.4%) in SEER during 2005–2013 (P < 0.05). However, these decreasing trends were not observed among Hispanics or those <10 years old. Conclusion Although the overall melanoma IR in children and adolescents appears to be decreasing, this trend is not evident among Hispanics and young children, implicating the need for further research investigating the etiologies and risk factors in these groups.

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Section: Discussionmentioning

confidence: 99%

Malignant melanoma incidence among children and adolescents in Texas and SEER 13, 1995–2013

Danysh

Navai

Scheurer

et al. 2019

Pediatric Blood & Cancer

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“…26 AM has been reported to affect only 1%-3% of melanoma subtypes affecting non-Hispanics and white-skinned populations in the United States and Europe. 27,28 However, it is the most common clinical subtype in Asians, 24,29,30 Latin Americans, 28,31 and Africans, 27,32 with an incidence of 40%-71%. Furthermore, AM is often diagnosed at advanced stages; approximately 60% of the patients are diagnosed with stage II or higher disease at first examination.…”

Section: Acr Al Mel Anomamentioning

confidence: 99%

Immune checkpoint inhibitor‐based therapy for advanced acral and mucosal melanoma

Mori

Izumi

Doi

et al. 2022

Experimental Dermatology

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The advent of immune checkpoint inhibitors (ICIs) including anti-PD-1 (pembrolizumab and nivolumab) and anti-CTLA-4 (ipilimumab) antibodies drastically changed treatment modalities for patients with various kinds of cancers, including lung cancer, 1 breast cancer, 2 oesophageal cancer, 3 urothelial cancer, 4 cervical cancer, 5 endometrial cancer, 6 renal cell carcinoma, 7,8 head and neck cancer, 9 Hodgkin lymphoma, 10 high microsatellite instability/ mismatch repair-deficient cancer, 11,12 tumour mutational burden (TMB)-high solid cancer, 13 and melanoma, 14,15 in advanced and/or adjuvant stage. ICIs are commonly used for treating advanced cutaneous melanoma (CM). In the phase III KEYNOTE-006 clinical trial, pembrolizumab resulted in an objective response rate (ORR) of 42% and a longer overall survival (OS) than ipilimumab (median OS: 32.7 months vs. 15.9 months; p < 0.001). 16 Likewise, the randomized phase III CheckMate-067 clinical trial demonstrated that nivolumab plus ipilimumab resulted in a better ORR and prolonged survival than nivolumab alone (ORR, 58% vs. 45%; median progression-free survival (PFS), 11.5 months vs. 6.9 months; median OS, not reached vs. 36.9 months). 17 Moreover, the 5-year OS has improved from <10% in patients with advanced stage CM treated with conventional chemotherapy, such as dacarbazine, to 30%-50%, especially in patients treated with anti-PD-1 antibody alone or in combination with ipilimumab. 16,18,19 CM is predominantly manifested in the sun-exposed skin of the Caucasian population. 20 However, melanomas rarely

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“…Due to its rarity the origin of oral melanomas and the risk factors are largely unknown. Certain races may be more commonly affected: the Japanese 12 , black Africans 13 , native Americans 14 and Hispanics 15 . A clearer correlation exists between melanomas of the oral mucosa and pre‐existing pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the oral cavity: case report

Bongiorno

Aricò

2002

Int J Dermatology

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An 80-year-old-female patient had a pigmented lesion on: the hard palate, the soft palate, the alveolar mucosa and the vestibular mucosa of the maxillary gingiva. Pigmented macules and patches had been persistent and asymptomatic for many years (Fig. 1). The lesion exhibited irregularities of pigmentation, border and surface contour. About 1 year later the patient had noticed an extension of the pigmented macules and plaques; there was also the appearance of nodules of the maxillary gingiva accompanied by swelling. Loosening of teeth as a result of extensive destruction of bone was further noted (Fig. 2). The histological examination showed a downward streaming in the dermis of the tumor cells and a disintegration and ulceration of the epidermis (Fig. 3). An increased number of large round or polygonal cells resembling atypical epithelioid cells were found on the submucosa. The atypical cells had enlarged, pleomorphic nuclei with prominent and sometimes multiple nucleoli. Mitoses were observed at various tissue levels (Fig. 4). Abundant pigmented melanin was present in the tumor cells (Fig. 5). Many cells had fine, dusty melanin particles. The tumor cells showed great variations in size. Immunohistochemical staining, with S100 protein and HMB45 antibodies, stained many of the spindleshaped cells, indicating that they were melanocytic cells. An inflammatory infiltrate of lymphocytes was seen in a band beneath the invading tumor cells.

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Melanoma Within a Southwestern Hispanic Population

Cited by 43 publications

References 22 publications

Malignant melanoma incidence among children and adolescents in Texas and SEER 13, 1995–2013

Malignant melanoma incidence among children and adolescents in Texas and SEER 13, 1995–2013

Immune checkpoint inhibitor‐based therapy for advanced acral and mucosal melanoma

Primary malignant melanoma of the oral cavity: case report

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