Melanomalignom: Immunfluorescenzph�nomene

Misgeld, V; Meisel, Chr

doi:10.1007/bf00600287

Arch. Derm. Forsch.

1972

DOI: 10.1007/bf00600287

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Melanomalignom: Immunfluorescenzph�nomene

V Misgeld

Chr Meisel

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1975

1977

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Der einflu� von autologem serum auf den leukocyten-migrations-inhibitions-test beim melanomalignom

Fritz

Grond

1977

Arch. Derm. Res.

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Influence of autologous serum on cellular immunological reactivity to melanomalignoma (MM)-associated antigens was examined on 20 patients have MM at different clinical stages, using the Leucocyte-Migration-Inhibition-Test (MIT). These 20 patients were referring to this till now not investigated. When heterologous serum (horse serum) was supplemented, an inhibition of cell-migration could be established in 15/20 cases, whereas a cell-migration inhibition in 14/20 cases was absent if autologous serum was added to culture medium. No correlation could be found between our test results and the clinical stage of the disease. Our results suggests urgently that blocking factors are present in serum of MM-patients. There is reason to believe that this factors will be active in lymphocyte level.

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Der einflu� von autologem serum auf den leukocyten-migrations-inhibitions-test beim melanomalignom

Fritz

Grond

1977

Arch. Derm. Res.

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Human melanoma FUHS-1

Misgeld

Meisel

1975

Arch. Derm. Res.

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Mitogene aktivit�t von melanomextrakten in leukocytenkulturen

Lischka¹

1975

Arch. Derm. Res.

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From a mixed cell suspension of five primary melanomas an aqueous sterile extract was made and added to homologue leucocyte cultures of eight melanoma patients and seven controls. The extract had a blastogenic and mitogenic effect in all cultures. There was no significant difference between the responses of patients and controls. In experiments with an equally prepared extract of normal skin, added to homologue leucocyte cultures of nine persons, none but one had a positive reaction. This indicates, that the motigenic principle of the melanoma extract is not related to the histocompatibility antigen nor caused by chemical or bacterial contamination of the primary cell suspensions. It seems to be derived from the cytoplasmic fraction of melanoma cells. Other experiments to solve the problem were impossible because of lack of material. There are several reports in the literature which by using different methods indicate, that there might be an immunological reaction to melanoma associated principles in healthy persons, too.

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Melanomalignom: Immunfluorescenzph�nomene

Cited by 3 publications

References 0 publications

Der einflu� von autologem serum auf den leukocyten-migrations-inhibitions-test beim melanomalignom

Der einflu� von autologem serum auf den leukocyten-migrations-inhibitions-test beim melanomalignom

Human melanoma FUHS-1

Mitogene aktivit�t von melanomextrakten in leukocytenkulturen

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