2018
DOI: 10.23880/cdoaj-1600013142
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Melanonychia Caused by Hydroxyurea in Hematologic Patients: Report of 4 Cases

Abstract: Melanonychia is a nail pigmentation disorder which is predominantly seen in female patients treated by hydroxyurea; especially in patients with diagnosed myeloproliferative disorders. Hydroxyurea inhibits DNA synthesis through its action on ribonucleoside diphosphate-reductase, and can be lead to dermatological disorders including mucocutaneous side effects and nail disorders such as onycholysis, onychodystrophy, and melanonychia. The pathogenesis of hydroxyurea-induced melanonychia is not clear. We present th… Show more

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