Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes

Assis, Leonardo Vinícius Monteiro de; Mendes, Davi; Silva, Matheus Molina; Kinker, Gabriela Sarti; Pereira-Lima, Isabella; Moraes, Maria Nathália; Menck, Carlos Frederico Martins; Castrucci, Ana Maria de Lauro

doi:10.1016/j.bbamcr.2020.118789

Cited by 26 publications

(49 citation statements)

References 47 publications

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“…At the same time, it emphasizes the key role of light in clock resettingeven at the peripheral tissue level. One may argue that mouse skin cells, which are known to be photosensitive [121][122][123][124][125] could be responsible for synchronizing the local clock in vivo. Indeed, such concept has been proven as neuropsin (OPN5) participates in light-induced clock gene synchronization of the skin [124].…”

Section: Relative Autonomy Of Peripheral Tissue Clocksmentioning

confidence: 99%

The circadian clock and metabolic homeostasis: entangled networks

Assis

Oster

2021

Cell. Mol. Life Sci.

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The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with biological processes and with the internal circadian clock. In this review, it is provided an in-depth view of the molecular functioning of the circadian molecular clock, how this system is organized, and how central and peripheral clocks communicate with each other. In this sense, we provide an overview of the neuro-hormonal factors controlled by the central clock and how they affect peripheral tissues. We also evaluate signals released by peripheral organs and their effects in the central clock and other brain areas. Additionally, we evaluate a possible communication between peripheral tissues as a novel layer of circadian organization by reviewing recent studies in the literature. In the last section, we analyze how the circadian clock can modulate intracellular and tissue-dependent processes of metabolic organs. Taken altogether, the goal of this review is to provide a systemic and integrative view of the molecular clock function and organization with an emphasis in metabolic tissues.

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Section: Relative Autonomy Of Peripheral Tissue Clocksmentioning

confidence: 99%

The circadian clock and metabolic homeostasis: entangled networks

Assis

Oster

2021

Cell. Mol. Life Sci.

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“…In addition to the effects of constant light on the SCN pathway, several previous studies have reported that constant light has direct effects on the skin 13–15 . The skin expresses several light‐sensitive opsin receptors, which mediate cellular responses to spectrally distinct wavelengths of visible and ultraviolet light 13 .…”

Section: Discussionmentioning

confidence: 99%

“…The skin expresses several light‐sensitive opsin receptors, which mediate cellular responses to spectrally distinct wavelengths of visible and ultraviolet light 13 . Some previous studies have found that the opsin receptors of the skin are responsible for mediating the local light‐dependent induction of circadian clock gene expression and circadian photoentrainment in exposed murine skin, leading to cell proliferation and apoptosis 14,15 . In addition, circadian arrhythmia induces spontaneous differentiation and loss of the capacity for self‐renewal in human epidermal stem cells 16 .…”

Section: Discussionmentioning

confidence: 99%

Effects of constant light exposure on allergic and irritant contact dermatitis in mice reared under constant light conditions

Mizutani¹,

Tamagawa‐Mineoka²,

Yasuike³

et al. 2021

Experimental Dermatology

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Environmental light levels can affect physiological functions, such as general activity, body temperature and metabolism. Irregular lifestyles, such as those involving exposure to light during the night, can exacerbate the clinical symptoms of several inflammatory skin diseases. However, the effects of constant light exposure on immune responses are not fully understood. This study aimed to elucidate the effects of constant light exposure on two major types of skin reactions, allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). BALB/c mice were kept under constant light conditions or a normal light and dark cycle, and their ACD and ICD responses were assessed after the topical application of 2,4,6‐trinitro‐1‐chlorobenzene and croton oil, respectively, to the ear skin. Interestingly, in both ACD and ICD, the ear‐swelling response and local leukocyte infiltration were aggravated by constant exposure to light, which has previously been shown to severely disturb the behavioural rhythms of mice. In ACD, these findings were accompanied by increases in the numbers of degranulated mast cells and eosinophils. These results suggest that constant light exposure intensifies allergic and non‐allergic skin inflammation.

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“…Similarly, Opn1 , Rho and Opn4 were also found in murine melanocytes 2,5 . In terms of function, RHO, OPN3 and/or OPN4 may detect light and ultraviolet radiation (UVR) and participate in pigmentary responses in human and murine melanocytes 5–7 …”

mentioning

confidence: 99%