Melanosis of the prostate: a rare benign morphological entity

Muzaffar, Suhail; Aijaz, Farrukh; Pervez, Shahid; Hasan, Sheema H

doi:10.1111/j.1464-410x.1995.tb07692.x

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…True melanin pigment in the epithelium is rare, and must be distinguished from lipofuscin; lipofuscin and melanin have been used interchangeably in some reports. In true melanosis, melanin is recognizable in both acinar epithelium and prostate stroma 196–202 . These lesions occur as incidental findings in prostate resection and biopsy specimens.…”

Section: Melanocytic Lesionsmentioning

confidence: 99%

“…These spindle cells are positive for S100 and negative for HMB45. Melanosis is also rare, with only 20 cases reported so far 196–202 . In three instances, melanin pigment was also seen in the glandular cells of the concomitant adenocarcinoma 196,200 …”

Section: Melanocytic Lesionsmentioning

confidence: 99%

“…Melanin in the prostate is associated with blue naevus, [189][190][191][192][193][194][195] melanosis, [196][197][198][199][200][201][202] and malignant melanoma, the latter being either primary [203][204][205][206] or metastatic. 207,208 Blue naevus is a benign lesion wherein the melanocytes are present only in the prostatic stroma.…”

Section: Melanocytic Lesionsmentioning

confidence: 99%

“…In true melanosis, melanin is recognizable in both acinar epithelium and prostate stroma. [196][197][198][199][200][201][202] These lesions occur as incidental findings in prostate resection and biopsy specimens. Blue naevus and melanosis are both benign and, to date, neither has been shown to progress to melanoma.…”

Section: Melanocytic Lesionsmentioning

confidence: 99%

“…Melanosis is also rare, with only 20 cases reported so far. [196][197][198][199][200][201][202] In three instances, melanin pigment was also seen in the glandular cells of the concomitant adenocarcinoma. 196,200 The origin of melanocytes in the prostate remains speculative.…”

Section: Melanocytic Lesionsmentioning

confidence: 99%

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Non‐epithelial neoplasms of the prostate

et al. 2011

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Non-epithelial prostatic neoplasms are infrequent and cover a broad array of entities that include both benign and highly aggressive tumours. Because they are very infrequent, there is often limited understanding of them, and the recognition of these entities, when encountered, may pose a diagnostic challenge, owing to histological overlap between them or their rarity. Most lesions in this category are mesenchymal in origin, such as prostatic stromal tumours arising from specialized prostatic stroma, smooth muscle tumours, both benign and malignant, and solitary fibrous tumours. Less commonly occurring tumours include neural, germ cell and melanocytic tumours that may be derived from cells not normally present in the prostate. Some tumours have well-established extraprostatic counterparts and, when encountered, are more commonly extraprostatic/secondary in origin; these include gastrointestinal stromal tumours and most haematopoietic tumours. The majority of tumours are characterized by a spindle cell pattern with significant overlap in morphological features. In this setting, appropriate use of immunohistochemistry and molecular studies are often necessary for accurate diagnosis, prognosis, or prediction for therapy. This review addresses and updates the clinicopathological features of the entire spectrum of non-epithelial tumours with an approach to the histological diagnosis.

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Section: Melanocytic Lesionsmentioning

confidence: 99%

Section: Melanocytic Lesionsmentioning

confidence: 99%