Melanotic Malignant Melanoma in Oculocutaneous Albinism Type 4

Ozaki, Saeko; Funasaka, Yoko; Otsuka, Yohei; Oyama, Satomi; Ito, Michiko; Osada, Shin‐Ichi; Ueno, Takashi; Okamura, Ken; Hozumi, Yasukazu; Suzuki, Tamio; Kawana, Seiji; Saeki, Hidehisa

doi:10.2340/00015555-2489

Cited by 11 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study in Nigeria, there were 68.2% SCC, 22.7% BCC and 9.1% melanoma [9]. A review had shown that BCC was observed in 5-88% of cases compared to 9-23% and 1.3-3% respectively for BCC and melanoma [19]. Indeed, the incidence of SCC doubles with every 8-10 degrees of decline in latitude with a maximum incidence at the equator [6].…”

Section: Discussionmentioning

confidence: 94%

Skin Cancers in People with Albinism in Togo in 2019: Results of Two Rounds of National Mobile Skin Care Clinics

Saka

Akakpo

Teclessou

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: The aim of this study was to determine the prevalence and histological types of skin cancers in people with albinism (PWA) in Togo in 2019.Methods: This is a cross-sectional study of medical records of PWA systematically examined during two mobile skin care clinics in 2019, as part of a programme for the prevention and management of skin cancers in these subjects. Results: During the study period, 280 (95.2%) of the 294 PWA consulted, had developed skin lesions. Of the 280 patients, the pathological reports from the medical records of 33 patients (11.8%) had concluded to keratinocytes skin cancers. The mean age of these 33 patients was 38.6±15.2 years and the sex-ratio was 1. Their occupations were mainly resellers (21.2%), traders (15.2%) and farmers (12.2%). In the 33 patients, 54 cases of keratinocytes skin cancers were identified, with some patients having more than one case or histological type. These 54 keratinocytes skin cancers were divided into 21 cases of invasive squamous cell carcinomas, 2 cases of Bowen’s disease and 31 cases of basal cell carcinomas. These keratinocytes skin cancers mainly occurred in the cephalic region (33 cases; 61.1%), the upper limbs (15 cases; 27, 8%) and the trunk (4 cases; 7.4%).Conclusion: The results of this study show a high prevalence of skin cancers among PWAs in Togo in 2019, only keratinocytes skin cancers. In addition, they illustrate the role of ultraviolet rays with regard to the localization of skin cancers and the occupations of patients. Popularization and compliance with photo protection measures, systematic and regular examination of the skin of these PWAs will allow early detection and treatment of these skin cancers.

show abstract

Section: Discussionmentioning

confidence: 94%

Skin Cancers in People with Albinism in Togo in 2019: Results of Two Rounds of National Mobile Skin Care Clinics

Saka

Akakpo

Teclessou

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…PM has been shown to contribute to melanomagenesis through both UV-dependent and independent pathways (Mitra et al, 2012); especially, the UVA photo-excitation of benzothiazine chromophores is associated with melanomagenesis through the generation of reactive oxygen species (ROS) (Napolitano, Panzella, Monfrecola, & D'ischia, 2014), indicating that the ratio of BZ-PM/BT-PM is important for carcinogenesis. In fact, patients with various types of OCA, including HPS, are known to be at increased risk of melanoma as well as for other skin cancers (Iwata et al, 2017;Ozaki et al, 2017). Although the correlation between hair and skin pigmentation remains unknown (Del Bino et al, 2015;Thody et al, 1991), it is conceivable that the degree of BZ-PM/BT-PM conversion seen in hair samples might serve as a marker to predict the risk of developing skin cancer.…”

Section: Discussionmentioning

confidence: 99%

Characterization of melanosomes and melanin in Japanese patients with Hermansky–Pudlak syndrome types 1, 4, 6, and 9

Okamura

Abe

Araki

et al. 2017

Pigment Cell Melanoma Res

View full text Add to dashboard Cite

Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism (OCA), a bleeding tendency, and ceroid deposition. Most of the causative genes for HPS encode subunits of the biogenesis of lysosome-related organelles complex (BLOC). In this study, we identified one patient each with HPS4, HPS6, and HPS9 by whole-exome sequencing. Next, we analyzed hair samples from the three patients and representative patients with HPS1 and controls using electron microscopy and chemical methods. All HPS patients had fewer, smaller, and more immature melanosomes than healthy controls. Further, all patients showed reduced total melanin content and increased levels of benzothiazine-type pheomelanin. The results of this study demonstrate the impact of the dysfunctions of BLOCs on the maturation of melanosomes and melanin levels and composition through analysis of their hair samples.

show abstract

“…In another study in Nigeria, there were 68.2% SCC, 22.7% BCC and 9.1% melanoma [9]. A review had shown that SCC was observed in 5-88% of cases compared to 9-23% and 1.3-3% respectively for BCC and melanoma [20]. Indeed, the incidence of SCC doubles with every 8-10 degrees of decline in latitude with a maximum incidence at the equator [6].…”

Section: Discussionmentioning

confidence: 94%

Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics

Saka

Akakpo

Teclessou

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancer. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization,) in PWA in 10 cities in Togo in 2019.Methods: This is a cross-sectional study of medical records of PWA systematically examined during two mobile skin care clinics in 2019, as part of a programme for the prevention and management of skin cancers in these subjects. Results: During the study period, 280 (95.2%) of the 294 PWA consulted, had developed skin lesions. Of the 280 PWA, the pathological reports from the medical records of 33 patients (11.8%; (95%CI= [8.2-16.2]) had concluded to non-melanoma skin cancers. The mean age of these 33 patients was 38.6±15.2 years and the sex-ratio was 1. Their occupations were mainly resellers (21.2%), traders (15.2%) and farmers (12.2%). In the 33 patients, 54 cases of non-melanoma skin cancers were identified, with some patients having more than one tumor, and some of them having more than one (histologically confirmed) diagnosis. These 54 non-melanoma skin cancers were divided into 21 cases of invasive squamous cell carcinomas, 2 cases of Bowen’s disease and 31 cases of basal cell carcinomas. These non-melanoma skin cancers mainly occurred in the head and neck (33 cases; 61.1%), the upper limbs (15 cases; 27, 8%) and the trunk (4 cases; 7.4%).Conclusion: The results of this study show a high prevalence of skin cancers among PWAs in Togo in 2019, only non-melanoma skin cancers. In addition, they illustrate the role of ultraviolet rays with regard to the localization of skin cancers and the occupations of patients. Popularization and compliance with photo protection measures, systematic and regular examination of the skin of these PWAs will allow early detection and treatment of these skin cancers.

show abstract

Melanotic Malignant Melanoma in Oculocutaneous Albinism Type 4

Cited by 11 publications

References 0 publications

Skin Cancers in People with Albinism in Togo in 2019: Results of Two Rounds of National Mobile Skin Care Clinics

Skin Cancers in People with Albinism in Togo in 2019: Results of Two Rounds of National Mobile Skin Care Clinics

Characterization of melanosomes and melanin in Japanese patients with Hermansky–Pudlak syndrome types 1, 4, 6, and 9

Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics

Contact Info

Product

Resources

About