Melanotic neuroectodermal tumor of infancy: a molecular approach to diagnosis

Nitta, Taizo; Endo, Toshitaka; Tsunoda, Akira; Kadota, Yoshiaki; Matsumoto, Takeshi; Satô, Kiyoshi

doi:10.3171/jns.1995.83.1.0145

Cited by 35 publications

(28 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On MRI scans, these lesions tend to be hyperintense on T1 and hypointense on T2 (21,22,24). Despite these characteristic findings, imaging will seldom be diagnostic and tissue biopsy is therefore required.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Melanotic neuroectodermal tumour of infancy

Hamilton¹,

MacRae²,

Agrawal³

2008

Plastic Surgery

View full text Add to dashboard Cite

Melanotic neuroectodermal tumour of infancy is an extremely rare neoplasm arising in newborns and young children, typically involving the face or cranium. A case arising from the maxilla, requiring extensive resection with a near-total maxillectomy, is presented. A thorough review of the literature on this unusual tumour is provided, with emphasis on prognostic factors and appropriate treatment.Key Words: Maxillectomy; Melanotic; MNTI; Pediatric; Pigmented Tumeur mélanotique neuroectodermique de l'enfance La tumeur mélanotique neuroectodermique de l'enfance, qui touche surtout la face et le crâne, est extrêmement rare chez les nouveau-nés et les jeunes enfants. Il sera question, dans l'article, d'un cas de tumeur du maxillaire, qui a nécessité une résection étendue, voire une maxillectomie quasi totale. Un examen exhaustif de la documentation sur ce type peu fréquent de tumeur, plus particulièrement sur les facteurs pronostiques et le traitement approprié, complétera l'étude du sujet.

show abstract

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…Computed tomography imaging typically reveals a welldemarcated, hyperdense lesion with contrast enhancement and hyperostosis of adjacent bone (21)(22)(23)(24). On MRI scans, these lesions tend to be hyperintense on T1 and hypointense on T2 (21,22,24).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy

Hamilton¹,

MacRae²,

Agrawal³

2008

Plastic Surgery

View full text Add to dashboard Cite

show abstract

“…Many reports of skull involvement [4,5,8,12,17,18,19,20,21] have appeared in the literature, and, in fact, extension into the brain parenchyma has been reported [13,22]. Reports also show that tumors in the skull arise from sutures [5,6], with the anterior fontanelle [8,12,23,24,25], temporoparietal [21] and frontotemporosphenoid [26] regions all being potential sites of involvement.…”

Section: Discussionmentioning

confidence: 99%

“…First described in 1918 by Krompecher as congenital melanocarcinoma, the entity has been called melanotic prognoma, melanotic ameloblastoma, atypical melanoblastoma and melanocytic neuroectodermal tumor, among others [1,2]. MNTI is of neural-crest, ectodermal origin and is pigmented secondary to melanin content [3,4,5]. While most commonly associated with the facial bones, including the maxilla and mandible, select cases have been described in the skull [6].…”

Section: Introductionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy with Involvement of the Superior Sagittal Sinus

Foster

Choudhri²,

Lingo

et al. 2016

Pediatr Neurosurg

View full text Add to dashboard Cite

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare lesion that typically manifests in the first year of life, most commonly involving the facial bones. We present 2 infants with MNTI involving the posterior skull with associated compression of the superior sagittal sinus (SSS). A review of the anatomical locations of MNTI is offered, and the implications of SSS involvement are described. This represents the first known description of MNTI with involvement of the posterior SSS.

show abstract

“…E l e c t ron microscopic and histochemical studies have now established that these tumors pro b a b l y originate from neural crest cells because of morphological similarities between tumor cells and melanocytes and between tumor cells and neuroblasts 14 . There are reports of high serum levels of a d renaline, noradrenaline and vanillylmandelic acid that further corroborate this hypothesis.…”

Section: First Described By Krompecher In 1918mentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy: case report

Antunes

Freitas

Oliveira

et al. 2005

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Introduction:Melanotic neuro e c t o d e rmal tumor of infancy (MNTI) is a rare tumor, locally aggressive, usually originated from maxilla and mandible and rarely from the skull. A case of a 4 monthold child presenting a bulging lesion in the midline of the occipitoparietal region with pro g ressive gro w t h is re p o rt e d . Case re p o rt: The neurologic examination had normal developmental milestones. Computerized tomography scan and magnetic resonance Image showed a highly enhancing tumor, dislocating anteriorly and inferiorly the superior sinuses. In order to prevent excessive bleeding, surgical resection was performed in three stages, with complete removal. Conclusion: Based on the absence of tumor recurrence, we believe in a favorable neurological prognosis and in a possible of cure, although the patient was not submitted to any adjuvant treatment.KEY WORDS: neuroectodermic melanotic tumor, cranial tumor, tumor of infancy.Tumor melanótico neuro-ectodérmico da Infância: relato de caso RESUMO -O tumor melanótico neuro -ectodérmico da infância é raro, localmente agressivo, originado da maxila ou da mandíbula, raramente originando-se da calota craniana. Relatamos o caso de um menino de 4 meses de idade que apresentava lesão abaulada com crescimento pro g ressivo no couro cabeludo. O exame neurológico apresentava desenvolvimento neuro-psicomotor adequado. A tomografia computadorizada e a ressonância magnética do encéfalo mostravam lesão que impregnava pelo contraste, deslocando anterior e inferiormente o seio sagital superior. Com o objetivo de prevenir o risco do sangramento excessivo, o procedimento foi realizado em três tempos, com remoção completa da lesão. Baseados na ausência de recidiva do tumor, acreditamos no bom prognóstico neurológico e na possibilidade de cura, embora o paciente não tenha sido submetido a nenhum tratamento adjuvante. PALAVRAS-CHAVE: tumor melanótico neuro-ectodérmico, tumor craniano, tumor da infância. D e p a rtment

show abstract

Melanotic neuroectodermal tumor of infancy: a molecular approach to diagnosis

Cited by 35 publications

References 24 publications

Melanotic neuroectodermal tumour of infancy

Melanotic neuroectodermal tumour of infancy

Melanotic Neuroectodermal Tumor of Infancy with Involvement of the Superior Sagittal Sinus

Melanotic neuroectodermal tumor of infancy: case report

Contact Info

Product

Resources

About