2002
DOI: 10.1159/000048346
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Melanotic Neuroectodermal Tumor of Infancy Discovered after Head Trauma

Abstract: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that generally arises in the maxilla during the first year of life. Involvement of bones of the cranial vault or brain is extremely rare. We describe a 7-month-old black female who presented after falling out of bed onto a concrete floor. Subsequently, she developed an anterior frontal mass that enlarged over several days. Radiographs of the skull at her local hospital showed a depressed right frontal skull fracture. However, computerized tom… Show more

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Cited by 12 publications
(6 citation statements)
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“…The neoplasm was fi rst described in 1918 by Krompecker, who described it as a melanocarcinoma (86). Its histogenesis is uncertain, but melanocytic neuroectodermal tumor is thought to have a neural crest origin (87). These lesions are believed to represent a dysembryogenic neoplasm that arises from the neural crest cells, based on fi ndings from ultrastructural, immunohistochemical, electron microscopic, and molecular genetic studies (88,89).…”
Section: Melanotic Neuroectodermal Tumor Of Infancymentioning
confidence: 99%
“…The neoplasm was fi rst described in 1918 by Krompecker, who described it as a melanocarcinoma (86). Its histogenesis is uncertain, but melanocytic neuroectodermal tumor is thought to have a neural crest origin (87). These lesions are believed to represent a dysembryogenic neoplasm that arises from the neural crest cells, based on fi ndings from ultrastructural, immunohistochemical, electron microscopic, and molecular genetic studies (88,89).…”
Section: Melanotic Neuroectodermal Tumor Of Infancymentioning
confidence: 99%
“…MNTI is most often benign; however, there is the potential for recurrence, metastasis and malignant degeneration [7,8,9,10,11]. Most patients experience a favorable outcome and long-term cure following gross total surgical resection [4,6,11,12]. …”
Section: Discussionmentioning
confidence: 99%
“…Many reports of skull involvement [4,5,8,12,17,18,19,20,21] have appeared in the literature, and, in fact, extension into the brain parenchyma has been reported [13,22]. Reports also show that tumors in the skull arise from sutures [5,6], with the anterior fontanelle [8,12,23,24,25], temporoparietal [21] and frontotemporosphenoid [26] regions all being potential sites of involvement.…”
Section: Discussionmentioning
confidence: 99%
“…These lesions may be locally aggressive but are generally classified as benign. 10,20 However, the potential for future malignancy cannot be ruled out or predicted based on histological features or clinical progression. 10 Histologically, MNTIs are biphasic tumors composed of nests of large melanin-containing epithelioid cells and small neuroblastic cells set within a fibrous stroma.…”
Section: Discussionmentioning
confidence: 99%
“…10 Histologically, MNTIs are biphasic tumors composed of nests of large melanin-containing epithelioid cells and small neuroblastic cells set within a fibrous stroma. 11,20 MNTIs may share some histological features with NCHs, such as melanin-containing cells, but they differ in that they do not have a differentiated neural component, are generally locally aggressive, and typically involve the craniofacial soft tissues, whereas NCHs most commonly occur on the scalp. 24 A CBN is another related entity and is clinically identified by a blue raised lesion, most commonly found in the sacrococcygeal region.…”
Section: Discussionmentioning
confidence: 99%