Melanotic Neuroectodermal Tumor of Infancy: Report of 2 Cases

Gonçalves, Cíntia Ferreira; Costa, Nádia Lago; Oliveira-Neto, Helenisa Helena; Jesus, Luciano A.; Sant'Ana, Simone Sousa Silva; Leles, José L.; Silva, Maria A.G.S.; Mendonça, Elismauro F.; Batista, Aline Carvalho

doi:10.1016/j.joms.2009.03.059

Cited by 12 publications

(13 citation statements)

References 29 publications

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“…Abbreviations: +M, presence of metastasis; −M, absence of metastasis; +R, presence of recurrence; −R, absence of recurrence; CS, conservative surgery (complete excision); CT, chemotherapy; LNM, lymph node metastasis; RS, radical surgery; RT, radiotherapy [Color figure can be viewed at wileyonlinelibrary.com] the disease. 13,18 Our analysis also revealed that the odds ratio of death among patients who showed regional lymph node metastasis was 23 times higher than in patients in whom lymph node metastasis was not observed. 3,8,18,23 Our study found that age is a significant prognostic factor.…”

Section: Discussionmentioning

confidence: 52%

“…5,6,12 MNTIs of the head and neck are uncommon aggressive lesions and mainly affect the jaw bones. [17][18][19] Further, our literature review demonstrated that 92.5% of tumors affected the maxilla and 7.5% affected the mandible. In previous studies, researchers observed that MNTI of the jaw bones is found mainly in children below 1 year of age.…”

Section: Discussionmentioning

confidence: 75%

“…13,14 To the best of our knowledge, this In our study, we observed that MNTI of the jaw bones occurs with the highest frequency from the second to sixth months of life. 13,18 Histologically, the tumor consists of a biphasic population of small neuroblast-like cells and larger melaninproducing epithelioid cells arranged in an alveolar architecture, with cords and trabeculae intersected by dense fibroblastic stroma. [15][16][17] We found a mean age of 6.5 months, with a higher age among males than females.…”

Section: Discussionmentioning

confidence: 99%

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Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

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The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty‐seven publications and 371 patients were included. The lesion was more prevalent in males and in the second to sixth months of life. The lesions mostly presented as a rapidly growing bluish swelling and the most commonly involved was the anterior maxilla. The mean follow‐up was 51.1 months (range 1‐408 months). Age (P ≤ .0001), location (P = .007), occurrence of lymph node metastasis (P ≤ .0001), treatment (P = .001), recurrence (P ≤ .0001), and distant metastasis (P = .0001) were independently associated with survival. Recurrence was significantly correlated with age (P = .0001), distant metastasis (P = .0001), and treatment (P = .0001). Patients older than 12 months, with lesions in the mandible, positive regional lymph node metastasis, treated with chemotherapy, recurrence, or distant metastasis presented the worst prognosis.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

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“…The lesions are usually benign, presenting as an aggressive, quick growing, and painless mass in the anterior maxilla [9] with irregular reddish-bluish pigmentation swelling on the top of the alveolar crest [10]. This mass may have a rubbery consistency and non-ulcerated surface, containing prematurely erupted or displaced primary teeth [11].…”

Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy in an African-indigenous patient from the Amazon: a case report

Pinheiro

Carneiro²,

Alves

et al. 2013

Head Face Med

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare condition that occurs normally in the anterior maxilla of infants aged <1 year. The use of clinical and imaging tools for MNTI is extremely important to prevent problems with function as well as the aesthetic features in a breastfeeding child. Brazil is a multiethnic country with a poor epidemiological policy and little data to track the incidence of certain diseases, including MNTI. It is important to study this pathology with ethnicity as a factor to improve the current epidemiological programs and establish better post-treatment management. This paper describes a case of a 2-month-old male of African-indigenous descent and Brazilian Amazon residency, who presented to our unit in 2009 with a history of an expanding mass involving the anterior maxilla. Clinical and computerized tomography scans were used to diagnose the mass as MNTI, which was removed by total excision. A biopsy later confirmed the MNTI diagnosis.

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“…2 Radiographs show an intrabony radiolucent lesion with a poorly defined radiolucent area. 3 Complete resection is the conventional treatment and recurrence rates vary from 10% to 60%. 2 The recurrent tumors grow more aggressively and can invade other anatomic structures, such as the nasal cavity, the orbit, and the skull base.…”

Section: Introductionmentioning

confidence: 99%

BRAFV600E Mutation in Melanotic Neuroectodermal Tumor of Infancy: Toward Personalized Medicine?

Gomes¹,

Diniz

Menezes

et al. 2015

Pediatrics

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The melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that primarily affects the maxilla of infants during their first year of life. Complete resection is the conventional treatment and recurrence rates vary from 10% to 60%. The recurrent tumors grow more aggressively and can invade other anatomic structures, such as the nasal cavity, the orbit, and the skull base. The aggressive behavior of MNTIs may require radical resection, which may not be possible in some cases because of its rapid and invading growth together with invasion of vital structures. In these situations, adjunct radiotherapy or chemotherapy has been used. However, as there are no conclusive data regarding the molecular profile of this tumor, currently there is no targeted therapy that may be used in the treatment of selected aggressive cases. On the basis of MNTI similarities with melanomas, such as derivation from the neural crest cells and presence of large melanin-containing cells, we hypothesized that MNTIs also may harbor the BRAFV600E oncogenic mutation. We show for the first time that this important pediatric tumor may harbor the oncogenic BRAFV600E mutation, providing the first insights to their personalized treatment.

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Melanotic Neuroectodermal Tumor of Infancy: Report of 2 Cases

Cited by 12 publications

References 29 publications

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Melanotic neuroectodermal tumor of infancy in an African-indigenous patient from the Amazon: a case report

BRAFV600E Mutation in Melanotic Neuroectodermal Tumor of Infancy: Toward Personalized Medicine?

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