Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report

Tiwari, Arunesh Kumar; Yadav, M

doi:10.7759/cureus.6521

Cited by 5 publications

(10 citation statements)

References 11 publications

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“…3,5 Malignant transformation and metastases was also reported. 9,16 Clinical manifestation of the tumor is a rapidly growing, painless, expansile, blueish-black pigmented mass, although the pigmentation may sometimes invisible due to the tissue covering it. It is considered as a benign tumor by the World Health Organization, despite its locally aggressive nature.…”

Section: Discussionmentioning

confidence: 99%

“…MNTI is recognized as a benign tumor, although it is locally aggressive and has a 3-6% possibility of distant metastases. 2,9,10 The clinical presentation of the tumor is a rapidly growing, painless, non-ulcerative, bluish-black mass on the anterior side of the maxilla. Adjunctive examination such as CT scan, histopathological through incisional biopsy, and examination of vanillylmandelic acid (VMA) was done to confirm the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Pigmented Neuroectodermal Tumor in Maxilla of an Infant : Report of a Rare Neoplasm in Bandung, Indonesia

Khamila

Oli'i

Hardianto

et al. 2022

IJMBS

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Introduction: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, locally invasive, fast-growing neoplasm with a high recurrence rate, which usually affecting children under 1 year of age. The tumor originated from the neural crest, most commonly found in the head and neck region, especially in the maxilla. Current standard for treatment is by surgical excision, but the high recurrency rate (10% - 60%) and the possiblity of malignant transformation makes the extent of excision debatable. Case report: An 8 -months-old boy was referred to our department with a rapidly growing mass in the anterior of the maxilla since two months prior. The mass was bluish in color, firm, and non-ulcerative. We treated the patient with excision under general anesthesia. Pathology examination was done and MNTI was confirmed. There is no recurrency at 2 years follow-up. Summary: Diagnosis and treatment of MNTI must be done meticulously due to the aggressive nature of the tumor. Wide surgical excision is the best treatment for this case, and routine follow-up must be done to detect any reccurency. Keywords: melanotic neuroectodermal tumor; infancy; maxilla, surgical excision

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pigmented Neuroectodermal Tumor in Maxilla of an Infant : Report of a Rare Neoplasm in Bandung, Indonesia

Khamila

Oli'i

Hardianto

et al. 2022

IJMBS

View full text Add to dashboard Cite

show abstract

“…The diagnosis of MNTI can be performed mainly by radiological characteristics in association with histopathological examinations ( 4 , 5 ). However, immunohistochemical analyses and molecular studies are useful and can contribute to the diagnosis of this neoplasm, especially in difficult cases and particularly in small biopsies with the possibility of differentiating this pathological change from other tumors present in childhood ( 6 - 9 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…The Melanotic Neuroectodermal Tumor of Infancy (MNTI) is an asymptomatic, pigmented neoplasm characterized by a fast and locally aggressive growth, in addition to a rare tissue formation ( 1 - 6 ).…”

Section: Introductionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Sousa¹,

Almeida²,

Mendes³

et al. 2022

Acta Stomatol Croat

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The Melanotic Neuroectodermal Tumor of Infancy (MNTI) is an asymptomatic, pigmented neoplasm characterized by a fast and locally aggressive growth along with a rare tissue formation. In the diagnostic process, the use of imaging exams can suggest a local destruction suggestive of malignancy, a sign of bone remodeling and expansion. Therefore, as any early diagnosis minimizes risks and improves the prognosis of treatment for the patient, the aim of this study was, based on a clinical case report, to corroborate the use of histopathological analysis associated with immunohistochemistry. Thus, we conclude that the immunohistochemical exam is of great importance for a better complementation of the MNTI diagnosis process. In addition, it can reveal signs of possible aggressive growth.

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“…In the past, because the origin of the neoplastic tissue was unknown, it was named “congenital melanoma,” “retinal basal tumor,” “mutant melanoma tumor,” and others. [ 2 ] In 1966, Borello and Gorlin [ 3 ] discovered that the level of vanillic acid (VMA) in the urine of a 3-month-old infant with MNTI was increased, and returned to normal following surgery. This observation suggested that it was likely that the tumor was of neural crest cell origin, which was subsequently confirmed.…”

Section: Introductionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy successfully treated with metformin

Tian²,

Wang³

et al. 2020

Medicine

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Rationale: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor originated from neural crest cells with the potential for recurrence and metastasis. The peak age for the disease is during the first year after birth. The current therapy is primarily surgery. The patient reported here is the first case of MNTI treated with metformin. Patient concerns: A case of a 4-month-old infant with a history of swelling in the mouth for 1 month. Diagnosis: The tumor was diagnosed using radiology, pathology, and immunohistochemistry, and it was performed with complete surgical resection. Unfortunately, the tumor recurred 3 months after surgery. Interventions: We prescribed metformin for the infant. Outcomes: Currently, after 9 months of treatment, the tumor is well controlled without apparent side effects. Lessons: The case presented suggested that metformin may be an underlying therapy for MNTI.

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Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report

Cited by 5 publications

References 11 publications

Pigmented Neuroectodermal Tumor in Maxilla of an Infant : Report of a Rare Neoplasm in Bandung, Indonesia

Pigmented Neuroectodermal Tumor in Maxilla of an Infant : Report of a Rare Neoplasm in Bandung, Indonesia

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Melanotic neuroectodermal tumor of infancy successfully treated with metformin

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