Melanotic oncocytic metaplasia of the nasopharynx

Xue, Weicheng; Hui, YH

doi:10.1046/j.1365-2559.1999.035005481.x

Cited by 11 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coexistence of melanin pigmentation and oncocytic metaplasia in the same gland characterizes the lesion. There have been only five cases reported thus far in the literature [10,11,22,30]. We report seven additional new cases and review the literature with an attempt to elucidate its possible pathogenesis and histogenesis.…”

Section: Introductionmentioning

confidence: 86%

Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature

et al. 2004

View full text Add to dashboard Cite

We describe seven cases of melanotic oncocytic metaplasia of the nasopharynx and review five other cases in the literature. It is usually a small, brown to black lesion that occurs around the Eustachian tube opening, where abundant seromucinous glands and lymphoid tissue are present. Multiple or bilateral lesions are sometimes seen. All 12 reported cases are of Asian origin. Melanotic oncocytic metaplasia occurs predominantly in men (male:female=11:1), with a mean age of 68 years. Simple excisional biopsy appears to be curative. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. Fontana-Masson staining and immunohistochemical staining of S-100 protein revealed numerous melanocytes with conspicuous dendrites in the glands and stroma, which probably transfer melanin to adjacent glands. The exact pathogenesis of melanotic oncocytic metaplasia is unknown, but we postulate that the lesion could be related to the oncocytic metaplasia of the seromucinous glands around the Eustachian tube, which is followed by the local production and/or acquisition of the melanin pigment, under the influence of certain neuropeptides in the vicinity. The recognition of melanotic oncocytic metaplasia is of clinical importance, as it may be misdiagnosed as a malignancy to the unwary.

show abstract

Section: Introductionmentioning

confidence: 86%

Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Females and males were overall equally affected (39 females, 37 males, 2 undetermined). Twelve cases of melanotic oncocytic metaplasia (MOM) affecting ET at the nasopharyngeal orifice (online only Table 1) are reported in literature (2 females, 10 males) [16][17][18][19][20][21][22][23]. Average age at diagnosis of MOM is 68 (range 56-81) years.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, few data on treatment and follow-up are available (Tables 2, 3, 4). MOM of ET nasopharyngeal opening can be associated with epistaxis, OM, tinnitus, ear, and throat discomfort of the adult patient, but without a certain causal relationship [16][17][18][19][20][21][22][23]. Similarities between MOM and extra-parotid Warthin's tumor have been noticed [16].…”

Section: Benign Tumors and Tumor-like Lesionsmentioning

confidence: 99%

See 1 more Smart Citation

Primary tumors and tumor-like lesions of the eustachian tube: a systematic review of an emerging entity

Muzzi

Cama

Boscolo‐Rizzo

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Eustachian tube (ET) primary tumors and tumor-like lesions are rare diseases presenting with common ear, nose and throat symptoms. Pathology can range from developmental anomalies to high malignant neoplasms. Hence this review aimed at suggesting a classification and outline relevant aspects of ET primary tumors and tumor-like lesions, describing clinical findings, diagnostic management and therapeutic approaches. MEDLINE, CINAHL, OVIDSP, HIGHWIRE, and GOOGLE databases were searched from inception to July 2011 for relevant studies. Further papers were identified by examining the reference lists of all included. Sixty-five papers met the inclusion criteria, enclosing 78 cases. Case reports are increasing in the past few years. Benign lesions and tumor-like lesions of ET have been reported. Moreover, melanomas, carcinomas, and sarcomas can affect the ET as a primary site.

show abstract

“…There have been only a few case reports and small study series. To date, only 20 cases have been reported in the English literature [2][3][4][5][6][7][8][9][10][11]. According to the literature, MOMN occurs predominantly in men (19 men: 1 woman) with a mean age of 68 years (range, 51 to 80 years), and exclusively occurs in East Asians, including Japanese [3,5,6,9], Chinese [2,4,10], Taiwanese [8] and Korean [11].…”

Section: Discussionmentioning

confidence: 99%