Melasma, a photoaging disorder

Passeron, Thierry; Picardo, Mauro

doi:10.1111/pcmr.12684

Cited by 186 publications

(223 citation statements)

References 34 publications

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…The increased number of spindle‐shaped p16 INK4A ‐positive fibroblasts is thought to originate from chronic UV irradiation. These findings are in line with the previous observations that melasma shows features of sun‐damaged skin and the in vitro UV‐induced senescence like phenotype of fibroblasts leads to the increased production of the melanogenic factors . The senescent cells were mainly observed in the upper layer of the dermis, which have the advantage of easy crosstalk with nearby melanocytes.…”

Section: Discussionsupporting

confidence: 91%

“…Immunohistochemical studies have shown that melasma shows prominent features of solar damaged skin compared with that in perilesional normal skin; lesional skin shows increased solar elastosis, vasculature and basement membrane disruption underlying increased epidermal pigmentation . These findings suggested in melasma skin, not only melanocytes but other actors, especially dermal components such as photoaged fibroblasts or vasculature, probably have a key role in the development and the relapses of melasma …”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Senescent fibroblasts in melasma pathophysiology

Kim

Kwon

et al. 2018

Experimental Dermatology

View full text Add to dashboard Cite

It has been proposed that melasma is a photoageing skin disorder. The photoaged fibroblasts have been suggested as an important source of melanogenic factors which are involved in the regulation of pigmentation. To investigate whether melasma includes senescent cells, lesional and perilesional normal skin from 38 melasma patients was assessed using a cell senescence marker, p16INK4A. The results showed that lesional dermal skin had more p16INK4A‐positive senescent cells than perilesional skin. The impact of senescent fibroblasts was further investigated in a pilot study using radiofrequency (RF) intervention for melasma. It showed that the RF therapy decreased the number of senescent cells with increased expression of procollagen‐1, which were associated with reduced epidermal pigmentation. This leads us to the speculation that senescent fibroblasts may contribute to drive melasma and might be considered as a potential therapeutic target.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Senescent fibroblasts in melasma pathophysiology

Kim

Kwon

et al. 2018

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…When co‐cultured with sebocyte cell line, human epidermal melanocytes showed dendrites formation and altered melanogenesis . Several cytokines and growth factors, such as IL‐1α, IL‐6, angiopoietin and adipokine, released from sebocytes have been demonstrated to exert paracrine effects on epidermal melanocytes . The role of sebocytes with respect to the pathogenesis of melasma requires further investigation.…”

Section: Histopathologic Clues Of Melasma As a Photoaging Disordermentioning

confidence: 99%

Melasma: Updates and perspectives

Kwon

Choi

et al. 2018

Experimental Dermatology

126

106

View full text Add to dashboard Cite

Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization and increased mast cell count. We also provide some therapeutic implications based on these findings and a discussion on the latest updates and perspectives regarding treatment.

show abstract

“…Though generally regarded as a pigmentary disorder, recent evidence has demonstrated melasma to be a photoaging disorder . The histological findings of melasma are similar to photoaging and include solar elastosis, increased mast cells and sebaceous glands, as well as altered basal membranes and vascularization .…”

Section: Introductionmentioning

confidence: 99%

Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

Wang

Lin

Chen

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions. Objective We aimed to compare the efficacy and tolerance of the picosecond alexandrite laser with those of DLA and TCC in female Asian patients with melasma. Methods Twenty‐nine patients were randomly assigned to group A1 (3 laser sessions at 4‐week intervals), A2 (5 laser sessions at 4‐week intervals) or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The Melasma Area, Severity Index (MASI) score and VISIA were assessed at baseline, week 12 and week 20. By week 20, the follow‐up periods for groups A1 and A2 were 3 months and 1 month, respectively. Results Nine, 11 and 6 participants in groups A1, A2 and B completed the study, respectively. MASI scores were significantly improved in all 3 groups at weeks 12 and 20. In groups A1, A2 and B, the improvement rates at week 20 were 53%, 38% and 50%, respectively. VISIA® analysis additionally revealed a significant improvement in spots, porphyria, pores and brown spots after 3 laser sessions (P < 0.05). Group A2 showed greater improvements than group A1 in terms of spots, wrinkles and pores; however, only red areas were significantly different (P < 0.001). All side‐effects in the 3 groups were transient and gradually subsided after 1–3 months. Conclusion Picosecond alexandrite laser treatment using DLA showed comparable efficacy with TCC for the treatment of melasma. Improvements in texture, spots, wrinkles and pores were observed in the laser groups. Patients with melasma lesions that exhibit telangiectasia may benefit from additional laser treatment sessions.

show abstract

Melasma, a photoaging disorder

Cited by 186 publications

References 34 publications

Senescent fibroblasts in melasma pathophysiology

Senescent fibroblasts in melasma pathophysiology

Melasma: Updates and perspectives

Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

Contact Info

Product

Resources

About