Melasma and Hypothyroidism: Conflicting Coexistence?

Aboobacker, Shamma; Karthikeyan, Kaliaperumal

doi:10.4172/2155-9554.1000429

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Aboobacker et al . also reported that 25% of melasma patients had also hypothyroidism, prevalence higher than controls . In contrast, Kumre et al .…”

Section: Discussionmentioning

confidence: 87%

Melasma and thyroid disorders: a systematic review and meta‐analysis

et al. 2019

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AbstractsBackground Thyroid hormones may play a key role in melasma; however, melasma link with thyroid disorders remains controversial.Objectives To compare the serum levels of thyroid-stimulating hormone (TSH), T4, T3, anti-thyroid peroxidase (anti-TPO), and antithyroglobulin between patients with melasma and control group using meta-analysis.Methods We screened 10 databanks and search engines, searched mesh and nonmesh terms. The identified evidences were reviewed and quality assessed using the Newcastle-Ottawa Scale (NOS). The heterogeneity between the primary results was investigated using Cochrane and I-square indices. Random effect model was applied to combine the standardized mean differences of thyroid function indicators between patients with and without melasma. P values meta-analysis was used to investigate the association between anti-TPO and melasma. ResultsWe included seven studies, 473 cases, and 379 controls that had been investigated. The total standardized mean differences (95% confidence intervals) of TSH, T3, T4, and antithyroglobulin antibody between cases and controls were estimated to be 0.33 (0.18, 0.47), À0.01 (À0.20, 0.19), À1.50 (À2.96, À0.04), and 0.62 (0.14, 1.11), respectively. The corresponding figures among women were 0.35 (0.17, 0.52), 0.10 (À0.17, 0.38), À2.75 (À6.30, 0.81), and 0.99 (0.14, 1.83), respectively. P value of metaanalysis showed a significant relationship between anti-TPO serum level and melasma (Fisher = 26.80, P = 0.020).Conclusion Serum levels of TSH, anti-TPO, and antithyroglobulin antibody were significantly higher in patients with melasma than those without melasma. Moreover, these differences were more severe among women with melasma. What is new?• Melasma is an acquired type of hyperpigmentation and might be associated with thyroid disorders.• Results of the present study showed that serum levels of TSH, anti-thyroid peroxidase (anti-TPO), and antithyroglobulin antibody were significantly higher in patients with melasma than those without melasma. Moreover, these differences were more severe among women with melasma.• Serum levels of TSH, anti-TPO, and antithyroglobulin antibodies are associated with melasma, especially among women. Risk of biasThe Newcastle-Ottawa Scale (NOS) checklist was applied to determine the risk of bias in primary studies. This checklist evaluates the studies in three section including selection (four scores), comparability (two scores), and exposure (three scores). Each study was achieved between 0 and 9 scores, and studies with less than five scores were removed from the metaanalysis. The quality assessment was performed by two independent methodologists. 20

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“…Aboobacker et al . also reported that 25% of melasma patients had also hypothyroidism, prevalence higher than controls . In contrast, Kumre et al .…”

Section: Discussionmentioning

confidence: 87%

Melasma and thyroid disorders: a systematic review and meta‐analysis

et al. 2019

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“…The prices causes of melasma are unclear, but a number of factors might be implicated in its AMJ, Vol. [5][6] . The effect of the UV light can be delineated when the lesions are getting worse during summer and they fade or even disappear in winter and colder seasons 3 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum thyroid hormones in female patients with melasma

Kamal¹,

Elethawi

2022

Adv.med.j.

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Background & Objectives: Melasma is an acquired hyperpigmented patches dispersed symmetrically on body parts that are exposed to sun, mostly on face of female patients. The precise etiology is obscure, but it has numerous hazards such as; ultra violet exposure, genetic factors, hormonal imbalances like thyroid hormone abnormalities. In this study we aimed to evaluate serum thyroid hormones levels in melasma patients. Methods: A complete of 51 female patients with melasma were enrolled during this study over a period of six months. The cases were clinically diagnosed and examined by Wood’s light, then sent for thyroid hormone levels assessment and the finding were reported. Results: In the current study 51 females with melasma. Their ages ranged between (19-46) years, with (59.9%) between (28-38) years. The duration of melasma was from 6 months to 9 years. Thirty-eight of them were married and had pregnancy. Thyroid stimulating hormone levels were high in 22 of them (43.1%), 20 out of 22 cases that was had high levels of thyroid stimulating hormone had dermal type of melasma by Wood’s lamp examination and their p-value was significant (0.001). Conclusion: We found significantly high levels of thyroid stimulating hormone in cases of melasma mainly among those of dermal type.

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Dermoscopic evaluation of tranexamic acid versus Vitamin C, with microneedling in the treatment of melasma: a comparative, split-face, single-blinded study

Tahoun

Mostafa

2021

Journal of Dermatological Treatment

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Melasma and Hypothyroidism: Conflicting Coexistence?

Cited by 3 publications

References 14 publications

Melasma and thyroid disorders: a systematic review and meta‐analysis

Melasma and thyroid disorders: a systematic review and meta‐analysis

Evaluation of serum thyroid hormones in female patients with melasma

Dermoscopic evaluation of tranexamic acid versus Vitamin C, with microneedling in the treatment of melasma: a comparative, split-face, single-blinded study

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