Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety

Satyanarayanan, Senthil Kumaran; Chien, Y.-C.; Chang, Jane Pei-Chen; Huang, Shih‐Yi; Guu, Ta-Wei; Su, Huanxing; Su, Kuan‐Pin

doi:10.1016/j.bbi.2019.03.003

Cited by 44 publications

(28 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The behavioural experiments indicate that APP/PSEN1-Tg mice showed early anxietylike and depressive-like traits, symptoms which would be expected to be associated with dysfunction of the amygdaloid, hippocampal and PFC circuitries. Supporting these observations, the genes Nr1d1 and Bhlhe41 , which have been previously associated with both control of circadian rhythms function and with depression 22,23 , were downregulated in the PFC of transgenic mice. Moreover, Plch1 is upregulated at 3 months old in the transgenic mice.…”

Section: Discussionsupporting

confidence: 71%

Behavioural and transcriptomic characterization of the comorbidity between Alzheimer’s disease and Major Depression

Martín‐Sánchez

Piñero

Nonell

et al. 2020

Preprint

View full text Add to dashboard Cite

Major Depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer s disease (AD). Despite both diseases having a robust genetic component, the common transcriptomic signature remains unknown. In this regard, we investigated the cognitive and emotional responses in 3- and 6-month-old in APP/PSEN1-Tg mutant mice, before beta-amyloid plaques were detected. Then, we studied the deregulation of genes and pathways in prefrontal cortex, striatum, hippocampus and amygdala, using transcriptomic and functional data analysis. The results demonstrated that depressive-like and anxiety-like behaviours, as well as memory impairments are already present at 3-month-old together with the deregulation of several genes and gene sets, including components of the circadian rhythms, electronic transport chain and neurotransmission. Finally, DisGeNET GSEA provides translational support for common depregulated gene sets related to MD and AD. Altogether, the results demonstrate that MD could be an early manifestation of AD.

show abstract

Section: Discussionsupporting

confidence: 71%

Behavioural and transcriptomic characterization of the comorbidity between Alzheimer’s disease and Major Depression

Martín‐Sánchez

Piñero

Nonell

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“… 15 , 16 Other inflammatory factors that have frequently been explored in insomnia are tumor necrosis factor (TNF)-α and IL-1β, with associations between elevated levels and poor sleep quality. 17–20 However, several other studies have shown no associations of insomnia with TNF-α and IL-1β. 21 , 22 In brief, previous studies on insomnia and inflammation have predominantly focused on CRP, IL-6, TNF-α, and IL-1β, with slightly varying findings.…”

Section: Introductionmentioning

confidence: 97%

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Xia¹,

Zhang²,

Niu³

et al. 2021

NSS

View full text Add to dashboard Cite

Purpose To examine whether associations exist between chronic insomnia disorder (CID) and overlooked inflammatory factors (Serum amyloid protein A [SAA]), tumor necrosis factor [TNF]-α, granulocyte-macrophage colony-stimulating factor [GM-CSF], and regulated on activation and normal T cell expressed and presumably secreted [RANTES]). Patients and Methods A total of 65 CID patients and 39 sex- and age-matched good sleeper (GS) controls participated in this study. They completed a baseline survey to collect data on demographics, and were elevated sleep and mood by Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), 17-item Hamilton Depression Rating Scale (HAMD-17) and 14-item Hamilton Anxiety Rating Scale (HAMA-14), respectively. The blood samples were collected and tested the serum levels of SAA, TNF-α, GM-CSF and RANTES. Results The CID group had higher serum levels of SAA, TNF-α, and GM-CSF and a lower level of RANTES than the GS group. In the Spearman correlation analysis, SAA and GM-CSF positively correlated with the PSQI and AIS scores. After controlling for sex, HAMD-17 score, and HAMA-14 score, the partial correlation analysis showed that GM-CSF was positively correlated with PSQI score. Further stepwise linear regression analyses showed that GM-CSF was positively associated with the PSQI and AIS scores, while RANTES was negatively associated with them, and SAA was positively associated with just the AIS score. Conclusion The serum levels of inflammatory mediators (SAA, TNF-α, and GM-CSF) were significantly elevated and the level of RANTES was significantly decreased in CID patients and, to some extent, the changes are related to the severity of insomnia. These findings may help us to improve interventions to prevent the biological consequences of CID by inhibiting inflammation, thereby promoting health.

show abstract

“…1c, f), symptoms which would be expected to be associated with dysfunction of the amygdaloid, hippocampal and PFC circuitries. Supporting these observations, the genes Nr1d1 and Bhlhe41, which have been associated with the control of circadian rhythm function and depression [63,64], were downregulated in the PFC of transgenic mice. Moreover, Plch1 is upregulated at 3 Fig.…”

Section: Discussionmentioning

confidence: 58%

Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice

et al. 2021

View full text Add to dashboard Cite

Background Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer’s disease (AD). Despite both diseases having a robust genetic component, the common transcriptomic signature remains unknown. Methods We investigated the cognitive and emotional behavioural responses in 3- and 6-month-old APP/PSEN1-Tg mice, before β-amyloid plaques were detected. We studied the genetic and pathway deregulation in the prefrontal cortex, striatum, hippocampus and amygdala of mice at both ages, using transcriptomic and functional data analysis. Results We found that depressive-like and anxiety-like behaviours, as well as memory impairments, are already present at 3-month-old APP/PSEN1-Tg mutant mice together with the deregulation of several genes, such as Ciart, Grin3b, Nr1d1 and Mc4r, and other genes including components of the circadian rhythms, electron transport chain and neurotransmission in all brain areas. Extending these results to human data performing GSEA analysis using DisGeNET database, it provides translational support for common deregulated gene sets related to MD and AD. Conclusions The present study sheds light on the shared genetic bases between MD and AD, based on a comprehensive characterization from the behavioural to transcriptomic level. These findings suggest that late MD could be an early manifestation of AD.

show abstract

Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety

Cited by 44 publications

References 93 publications

Behavioural and transcriptomic characterization of the comorbidity between Alzheimer’s disease and Major Depression

Behavioural and transcriptomic characterization of the comorbidity between Alzheimer’s disease and Major Depression

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice

Contact Info

Product

Resources

About