Melatonin

Al-Omary, Fatmah A. M.

doi:10.1016/b978-0-12-407691-4.00005-8

Cited by 26 publications

(7 citation statements)

References 216 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is secreted by the vertebrate pineal gland situated in the brain and is stimulated in darkness (200 pg mL À1 ) and suppressed by daylight (10 pg mL À1 ), thereby regulating the circadian rhythm. [1][2][3] Melatonin is used as a chronobiotic that is capable of normalizing the disturbed circadian rhythms, including sleepwake rhythms and imbalances imposed by jet lag or shi work. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction.…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. 1,4,5 In mammals, melatonin activates G proteincoupled receptors, the melatonin receptor 1 (MT 1 ) and melatonin receptor 2 (MT 2 ), present in many regions of the central nervous system and exert cellular and physiological actions including neuronal ring, arterial vasoconstriction, cell proliferation, immune responses, reproductive and metabolic functions. 6 Melatonin also behaves as an effective antioxidant and anti-inammatory hormone that enhances the activity of antioxidant enzymes and diminishes oxidative injury.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Graphene and Co-polymer composite based molecularly imprinted sensor for ultratrace determination of melatonin in human biological fluids

Gupta

Goyal

2015

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Graphene and Co-polymer composite based molecularly imprinted sensor for ultratrace determination of melatonin in human biological fluids

Gupta

Goyal

2015

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Equally important to point out is that significant short- and long-term side effects after administration of standard and high doses (20 mg) of melatonin in children have not been reported [ 74 , 75 , 76 , 77 , 78 ].…”

Section: Discussionmentioning

confidence: 99%

Analgesic, Anxiolytic and Anaesthetic Effects of Melatonin: New Potential Uses in Pediatrics

Marseglia

Manti

Aversa

et al. 2015

IJMS

View full text Add to dashboard Cite

Exogenous melatonin is used in a number of situations, first and foremost in the treatment of sleep disorders and jet leg. However, the hypnotic, antinociceptive, and anticonvulsant properties of melatonin endow this neurohormone with the profile of a drug that modulates effects of anesthetic agents, supporting its potential use at different stages during anesthetic procedures, in both adults and children. In light of these properties, melatonin has been administered to children undergoing diagnostic procedures requiring sedation or general anesthesia, such as magnetic resonance imaging, auditory brainstem response tests and electroencephalogram. Controversial data support the use of melatonin as anxiolytic and antinociceptive agents in pediatric patients undergoing surgery. The aim of this review was to evaluate available evidence relating to efficacy and safety of melatonin as an analgesic and as a sedative agent in children. Melatonin and its analogs may have a role in antinociceptive therapies and as an alternative to midazolam in premedication of adults and children, although its effectiveness is still controversial and available data are clearly incomplete.

show abstract

“…The synthesis of melatonin decreases with age, often causing insomnia; the largest decline could be observed in the cases of Alzheimer's disease, cardiovascular issues, and cancer [19]. Usually, melatonin is safe and not toxic; even at high doses only mild side effects, such as dizziness, headaches, nausea, and sleepiness, could be observed [20].…”

Section: Melatonin Biosynthesis and Bioavailabilitymentioning

confidence: 99%

Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease

Kopustinskienė

Bernatonienė

2021

Pharmaceutics

View full text Add to dashboard Cite

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting beneficial action in many pathological conditions. Melatonin protects from oxidative stress in ischemic/reperfusion injury, neurodegenerative diseases, and aging, decreases inflammation, modulates the immune system, inhibits proliferation, counteracts the Warburg effect, and promotes apoptosis in various cancer models. Melatonin stimulates antioxidant enzymes in the cells, protects mitochondrial membrane phospholipids, especially cardiolipin, from oxidation thus preserving integrity of the membranes, affects mitochondrial membrane potential, stimulates activity of respiratory chain enzymes, and decreases the opening of mitochondrial permeability transition pore and cytochrome c release. This review will focus on the molecular mechanisms of melatonin effects in the cells during normal and pathological conditions and possible melatonin clinical applications.

show abstract

Melatonin

Cited by 26 publications

References 216 publications

Graphene and Co-polymer composite based molecularly imprinted sensor for ultratrace determination of melatonin in human biological fluids

Graphene and Co-polymer composite based molecularly imprinted sensor for ultratrace determination of melatonin in human biological fluids

Analgesic, Anxiolytic and Anaesthetic Effects of Melatonin: New Potential Uses in Pediatrics

Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease

Contact Info

Product

Resources

About