Melatonin Administration Affects Plasma Total Sialic Acid and Lipid Peroxidation Levels in Streptozotocin Induced Diabetic Rats

Abstract

Administration of streptozotocin (STZ) was used to induce diabetes, as the mechanism involved is believed associated with generation of free radicals. Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes. The aim of this study was to determine whether the STZ-induced effects on plasma thiobarbituric acid-reactive substances (TBARS, a marker of lipid peroxidation) and total sialic acid levels could be blocked by melatonin. STZ significantly increased the plasma levels of sialic acid and TBARS. Treatment with melatonin markedly reduced the STZ-induced effects on plasma sialic acid and TBARS and was associated with restoration of hyperglycemia to control blood glucose levels. These data suggest that melatonin protects against oxidative damage, and daily supplementation with melatonin may be beneficial for diabetics.

Transient desialylation in combination with a novel antithrombin deficiency causing a severe and recurrent thrombosis despite anticoagulation therapy

“…The endogenous overexpression or mislocalization of sialidases induced by an unknown factor may be proposed as an interesting hypothesis. In this framework, several studies have reported impaired sialylation related to oxidative stress22232425. Oxidant injury/free radical reactions observed in diabetes, malignancy, and aging can cause desialylation and carbonylation of platelet proteins in vitro 22.…”

Role of melatonin on diabetes-related metabolic disorders

“…Taken together, streptozotocin-induced diabetes increases oxidative stress through generation of free radicals [87] , lipid peroxidation, superoxide dismutase, protein glycosylation [88] , decreased levels of catalase and glutathione peroxidase [89] , as well as DNA single-strand breaks [85] . In the serum of animals with streptozotocin-induced diabetes, melatonin remarkably reduces the degree of both lipid peroxidation and protein glycosylation [88] , decreases the levels of cholesterol, triglyceride, low-density lipoprotein [90] , sialic acid [91] and glucose [92] , as well as possibly regulating the activities of antioxidant enzymes [89] . Nevertheless, the most pronounced effect of melatonin administration was the prevention of an increase in NO levels in blood plasma during streptozotocin-induced diabetes [93] , which implies that melatonin may operate as an NO scavenger and carrier.…”

Protective Effect of Melatonin on the Oxidative Stress Caused by Diabetes and Forced Swimming Exercise on Rat Brain Tissue

“…12 Consequently, many researchers reported that diabetes increased lipid peroxidation in experimental animals. [20][21][22] In any case, diabetes is used as a model of oxidative damage in experimental animals. 12,22 Elevated MDA levels we obtained in the brain tissue of the diabetes group (Group 8), which was not subjected to any additional procedure, are consistent with the results of the above-cited researchers.…”

“…[20][21][22] In any case, diabetes is used as a model of oxidative damage in experimental animals. 12,22 Elevated MDA levels we obtained in the brain tissue of the diabetes group (Group 8), which was not subjected to any additional procedure, are consistent with the results of the above-cited researchers. However, in the present study, we established the highest brain MDA values in the diabetes group subjected to swimming exercise (Group 7).…”

“…27,28 The fact that melatonin-supplementation brought about a strong antioxidant effect in diabetic rats has made researchers focus on the protective effect of melatonin in diabetes. 29,22 It has even been noted that low circulatory levels of melatonin may be associated with the development of diabetes. 30 Baydas et al have impressively shown that the oxidant damage in the brain tissue of diabetic rats is inhibited in parallel to elevated GSH levels with melatonin supplementation.…”