Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg in young male Zucker diabetic fatty rats

Navarro-Alarcón, Miguel; Ruiz‐Ojeda, Francisco Javier; Blanca-Herrera, Rosa M.; Kaki, Abdullah M.; Adem, Abdu; Agil, Ahmad

doi:10.1039/c3fo60389j

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…16,31 These findings together with the great role played by melatonin in the reduction of free fatty acid and oxidative or nitrosative stress emphasize the beneficial effect of melatonin treatment on age related insulin resistance and on the development of T2DM. 18 As noted above, melatonin administration can increase plasma levels of V and Cr, which are both related to glucose tolerance, 32 and it can reduce the body weight of ZDF rats for the same food intake, related to an improved lipid profile. 31 The relationship between melatonin and Ca 2+ flux regulation has been studied in numerous cells.…”

Section: Resultsmentioning

confidence: 95%

“…However, the increased Ca 2+ in the studied tissues, especially in WAT [visceral omental, gonadal and renal] and lumbar subcutaneous fat samples, does not imply an increase in mitochondrial levels, because melatonin was found to inhibit Ca 2+induced mPTP opening in isolated mitochondria, 41 but it is associated with the decreased oxidative stress described in previous studies using the same animal model. 22,31,32 In humans, GLUT4 protein is encoded by the GLUT4 gene and is a well-known insulin-regulated glucose transporter. The liver is considered the main organ involved in maintaining normal glucose homeostasis through its role in regulating hepatic gluconeogenesis and glycolysis.…”

Section: Resultsmentioning

confidence: 99%

“…[25][26][27] This process is mediated by the activation of the Ca 2+ /calmodulin-dependent protein kinase (CaMKII), which is also required for Ca 2+ homeostasis and its reuptake. 16,17,31,32 Importantly, melatonin also affects CaMKII protein levels, probably acting indirectly via the Ca 2+calmodulin signaling pathway for regulating insulin secretion. 6,30 We have found no published study on the effect of melatonin supplementation on the regulation of Ca 2+ levels in tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Our group previously reported that melatonin administrations improve various biomarkers associated with type 2 diabetes mellitus (T2DM) through its effect on chromium (Cr) and vanadium (V). 16,17,31,32 Importantly, melatonin also affects CaMKII protein levels, probably acting indirectly via the Ca 2+calmodulin signaling pathway for regulating insulin secretion. 33 Hence, melatonin can enhance the capacity of β cells to respond to metabolic signals by impacting on this kinase group.…”

Section: Introductionmentioning

confidence: 99%

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Melatonin increases intracellular calcium in the liver, muscle, white adipose tissues and pancreas of diabetic obese rats

et al. 2015

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Melatonin, a widespread substance with antioxidant and anti-inflammatory properties, has been found to act as an antidiabetic agent in animal models, regulating the release and action of insulin. However, the molecular bases of this antidiabetic action are unknown, limiting its application in humans. Several studies have recently shown that melatonin can modify calcium (Ca(2+)) in diabetic animals, and Ca(2+) has been reported to be involved in glucose homeostasis. The objective of the present study was to assess whether the antidiabetic effect of chronic melatonin at pharmacological doses is established via Ca(2+) regulation in different tissues in an animal model of obesity-related type 2 diabetes, using Zücker diabetic fatty (ZDF) rats and their lean littermates, Zücker lean (ZL) rats. After the treatments, flame atomic absorption spectrometry was used to determine Ca(2+) levels in the liver, muscle, main types of internal white adipose tissue, subcutaneous lumbar fat, pancreas, brain, and plasma. This study reports for the first time that chronic melatonin administration (10 mg per kg body weight per day for 6 weeks) increases Ca(2+) levels in muscle, liver, different adipose tissues, and pancreas in ZDF rats, although there were no significant changes in their brain or plasma Ca(2+) levels. We propose that this additional peripheral dual action mechanism underlies the improvement in insulin sensitivity and secretion previously documented in samples from the same animals. According to these results, indoleamine may be a potential candidate for the treatment of type 2 diabetes mellitus associated with obesity.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melatonin increases intracellular calcium in the liver, muscle, white adipose tissues and pancreas of diabetic obese rats

et al. 2015

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“…In addition to ROS/RNS, many other molecules could be modulated or scavenged by melatonin and its metabolites, such as hemoglobin-derived oxoferryl radicals [135]. Furthermore, in vitro and/or in vivo, melatonin is able to chelate toxic metals such as cadmium [136], mercury [137], arsenic [138], lead [139], aluminum [140], chromium [141], which are involved in the generation of free radicals. Moreover, melatonin and its metabolites were also documented to exhibit free radical avoidance properties, by downregulating pro-oxidative enzymes like inducible nitric oxide synthase (iNOS) both in vitro (dose-dependent) and in vivo as well as inhibiting the mRNA expression of cyclo-oxygenase 1 (COX-1) and COX-2 in human breast cancer cells (MCF-7) [142,143].…”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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