Melatonin, adolescence, and the brain: An insight into the period‐specific influences of a multifunctional signaling molecule

Onaolapo, Olakunle James; Onaolapo, Adejoke Yetunde

doi:10.1002/bdr2.1171

Cited by 25 publications

(17 citation statements)

References 170 publications

(197 reference statements)

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“…It is also involved in the maintenance of antioxidant balance, proper functioning of the immune system, and protection of the cardiovascular system. It exerts an antioxidant effect on organs and anti-apoptotic effect on cells [120]. Melatonin easily moves across the cell membrane [121], blood-brain barrier [122], and protects various biomolecules by detoxifying ROS and RNS.…”

Section: Melatoninmentioning

confidence: 99%

Role of Antioxidants in Alleviating Bisphenol A Toxicity

2020

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Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA-induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA-associated stress. We summarize the current knowledge on the biological function of enzymatic and non-enzymatic antioxidants, and discuss their practical potential as BPA-detoxifying agents.

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Section: Melatoninmentioning

confidence: 99%

Role of Antioxidants in Alleviating Bisphenol A Toxicity

2020

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“…Such differences may partially underlie the difficulty in mood regulation, sleepiness, and learning problems in adolescents [17]. Since brain development is continuing during puberty, and melatonin modulates neuronal plasticity, the changes in this neurohormone (together with others such as sex and stress hormones) may incline this age group to many psychological disturbances [18]. …”

Section: Role Of Melatonin During Human Life Stagesmentioning

confidence: 99%

Mechanisms Underlying Tumor Suppressive Properties of Melatonin

Bondy

Campbell

2018

IJMS

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There is considerable evidence that melatonin may be of use in the prevention and treatment of cancer. This manuscript will review some of the human, animal and cellular studies that provide evidence that melatonin has oncostatic properties. Confirmation that melatonin mitigates pathogenesis of cancer will be described from both direct study of its effects on carcinogenesis, and from indirect findings implicating disruption of the circadian cycle. A distinction is made between the role of melatonin in preventing the initiation of the tumorigenic pathway and the ability of melatonin to retard the progression of cancer. Melatonin appears to slow down the rate of advancement of established tumors and there is evidence that it constitutes a valuable complement to standard pharmacological and radiation treatment modalities. There are instances of the beneficial outcomes in cancer treatment which utilize a range of hormones and vitamins, melatonin being among the constituents of the mix. While these complex blends are empirically promising, they are only briefly mentioned here in view of the confounding influence of a multiplicity of agents studied simultaneously. The last section of this review examines the molecular mechanisms that potentially underlie the oncostatic effects of melatonin. Alterations in gene expression following activation of various transcription factors, are likely to be an important mediating event. These changes in gene activity not only relate to cancer but also to the aging process which underlies the onset of most tumors. In addition, epigenetic events such as modulation of histone acetylation and DNA methylation patterns throughout the lifespan of organisms need to be considered. The antioxidant and immunoregulatory roles of melatonin may also contribute to its cancer modulatory properties. Naturally, these mechanisms overlap and interact extensively. Nevertheless, in the interest of clarity and ease of reading, each is discussed as a separate topic section. The report ends with some general conclusions concerning the clinical value of melatonin which has been rather overlooked and understudied.

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“…Melatonin is a tryptophan-derived indoleamine which is primarily secreted by the pineal gland, with contributions from a number of other tissues including the retina, bone marrow, gastrointestinal tract, skin, ovary and placenta[ 117 , 118 ]. The extra-pineal contribution to melatonin production is small when compared to secretion from the pineal gland; with suggestions that it is only triggered by some specific impulses[ 119 ].…”

Section: Melatoninmentioning

confidence: 99%

“…Plasma concentrations of endogenous melatonin also vary considerably with age[ 120 - 122 ]. Melatonin is a multifunctional molecule that is capable of intracrine, paracrine or autocrine signalling[ 117 ]. It can cross all physiological barriers and exert widespread regulatory effects on numerous body tissues.…”

Section: Melatoninmentioning

confidence: 99%

Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin’s roles in prophylaxis and management

Onaolapo¹,

Onaolapo²

2018

WJD

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Diabetes mellitus is a chronic, life-threatening metabolic disorder that occurs worldwide. Despite an increase in the knowledge of the risk factors that are associated with diabetes mellitus, its worldwide prevalence has continued to rise; thus, necessitating more research into its aetiology. Recent researches are beginning to link a dysregulation of the circadian rhythm to impairment of intermediary metabolism; with evidences that circadian rhythm dysfunction might play an important role in the aetiology, course or prognosis of some cases of diabetes mellitus. These evidences thereby suggest possible relationships between the circadian rhythm regulator melatonin, and diabetes mellitus. In this review, we discuss the roles of the circadian rhythm in the regulation of the metabolism of carbohydrates and other macronutrients; with emphasis on the importance of melatonin and the impacts of its deficiency on carbohydrate homeostasis. Also, the possibility of using melatonin and its analogs for the “prophylaxis” or management of diabetes mellitus is also considered.

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Melatonin, adolescence, and the brain: An insight into the period‐specific influences of a multifunctional signaling molecule

Cited by 25 publications

References 170 publications

Role of Antioxidants in Alleviating Bisphenol A Toxicity

Role of Antioxidants in Alleviating Bisphenol A Toxicity

Mechanisms Underlying Tumor Suppressive Properties of Melatonin

Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin’s roles in prophylaxis and management

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