Melatonin Alleviates Renal Injury in Mouse Model of Sepsis

Chen, Liyang; Han, Ze‐Guang; Shi, Z.B.; Liu, Chao; Lu, Qiulun

doi:10.3389/fphar.2021.697643

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…As revealed by prior investigations, excessive ROS-induced oxidative stress may result in chronic inflammation [4][5][6], which is an important characteristic of inflammatory response as well as a crucial factor for tissue and organ fibrosis [7,8]. As an antioxidant and anti-inflammatory substance, Rg1 can inhibit the ROS level in LPS-induced cardiomyocytes [22].…”

Section: Discussionmentioning

confidence: 95%

“…Previous studies have shown that chronic inflammation can cause the accumulation of reactive oxygen species (ROS) [4][5][6], which is an important characteristic of the inflammatory response as well as a crucial contributor to tissue and organ fibrosis [7,8]. According to prior research, mitochondrial oxidative stress is a trigger to activate NOD-like receptor protein 3 inflammasome (NLRP3) [9], which induces various organ pathological fibrosis, including hepatic [10], renal [11], and cardiac [12].…”

Section: Introductionmentioning

confidence: 99%

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Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3

Song,

Wang,

et al. 2023

Animals

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Abnormal function and the fibrosis of endometrium caused by endometritis in cows may lead to difficult embryo implantation and uterine cavity adhesions. Emerging evidence indicates that ginsenoside Rg1 can effectively resist inflammation and pathological fibrosis in different organs. It is hypothesized that ginsenoside Rg1 may possess the potential to mitigate endometrial fibrosis induced by lipopolysaccharides (LPS) in dairy cows. Herein, a model of LPS-stimulated fibrosis was constructed using bovine endometrial epithelial cell line (BEND) cells and ICR mice. Western blotting was used to detect the protein level, and reactive oxygen species (ROS) content was measured by means of DCFH-DA. The uterine tissue structure was stained with H&E and Masson staining. The murine endometrium was assessed for oxidative stress by detecting the concentration of MDA together with the activity of enzymatic antioxidants SOD and CAT. Ginsenoside Rg1 interfered with NLRP3 activation by reducing ROS generation. After the application of ROS inhibitor NAC and NLRP3 inhibitor MCC950, ginsenoside Rg1 could interfere in the ROS/NLRP3 inflammasome signaling pathway by suppressing the epithelial–mesenchymal transition (EMT) of BEND cells. Our in vivo data showed that ginsenoside Rg1 relieved endometrial fibrosis of the mouse model of LPS-induced endometritis by restraining the ROS/NLRP3 inflammasome signaling pathway. Ginsenoside Rg1 inhibits LPS-induced EMT progression in BEND cells probably by inhibiting the activation of ROS-NLRP3 inflammasome.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3

Song,

Wang,

et al. 2023

Animals

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“…The oxidative status consequently was changed during excessive inflammation caused by acute injury (24). We first investigated the level of ROS and found significant upregulation of ROS in the pulmonary section after ALI, which was restrained by BBR treatment (Figure 2A).…”

Section: Berberine Eliminates Excessive Inflammation In Alimentioning

confidence: 99%

Berberine Ameliorates Inflammation in Acute Lung Injury via NF-κB/Nlrp3 Signaling Pathway

et al. 2022

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The inflammatory response is the key pathophysiological character of acute lung injury (ALI). Berberine (BBR), a natural quaternary ammonium alkaloid, plays a functional role in anti-inflammation both in vitro and in vivo. However, the underlying mechanism between BBR and ALI has not been expounded. Here, we found that BBR improved the permeability of pulmonary and repressed the inflammatory factors in the lipopolysaccharides (LPSs)-induced ALI model. We demonstrated that BBR could suppress the expression of phosphorylated nuclear factor-kappa B (NF-κB) and further restrain the downstream gene nucleotide-binding domain and leucine-rich repeat protein-3 (Nlrp3). Moreover, we also revealed that BBR could directly interact with Nlrp3 protein. After knocked down of Nlrp3 by using siRNA, the protective role of BBR was abrogated in vitro. The expression of IL-1β and IL-18 was downregulated by BBR via the two signaling pathways. Notably, in Nlrp3 deficient mice, the protective effect of BBR was abolished. These findings demonstrate that BBR has a depressant effect on inflammatory response caused by LPS via regulating NF-κB/Nlrp3 signaling pathway, providing a potential therapeutic strategy in ALI.

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“…Toon et al found that melatonin is a promising drug for the treatment of a chronic kidney disease (CKD) patient with renal fibrosis; melatonin could recover mitochondrial function by upregulating the miR-4516 expression to decrease ROS formation ( Yoon et al, 2020 ). In response to acute kidney injury induced by sepsis, melatonin could reduce the oxidative stress response and ROS accumulation of ROS in vitro and attenuate the inflammatory response by downregulating the mRNA expressions of IL-1α, IL-1β, Mcp-1 and TGF-β1, thereby proving the therapeutic effect of melatonin on acute kidney injury ( Chen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis

et al. 2022

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Indole alkaloids are widely distributed in nature and have been particularly studied because of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and anti-oxidant activities. Many kinds of indole alkaloids have been applied to clinical practice, proving that indole alkaloids are beneficial scaffolds and occupy a crucial position in the development of novel agents. Fibrosis is an end-stage pathological condition of most chronic inflammatory diseases and is characterized by excessive deposition of fibrous connective tissue components, ultimately resulting in organ dysfunction and even failure with significant morbidity and mortality. Indole alkaloids and indole derivatives can alleviate pulmonary, myocardial, renal, liver, and islet fibrosis through the suppression of inflammatory response, oxidative stress, TGF-β/Smad pathway, and other signaling pathways. Natural indole alkaloids, such as isorhynchophylline, evodiamine, conophylline, indirubin, rutaecarpine, yohimbine, and vincristine, are reportedly effective in organ fibrosis treatment. In brief, indole alkaloids with a wide range of pharmacological bioactivities are important candidate drugs for organ fibrosis treatment. The present review discusses the potential of natural indole alkaloids, semi-synthetic indole alkaloids, synthetic indole derivatives, and indole-contained metabolites in organ fibrosis treatment.

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Melatonin Alleviates Renal Injury in Mouse Model of Sepsis

Cited by 9 publications

References 22 publications

Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3

Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3

Berberine Ameliorates Inflammation in Acute Lung Injury via NF-κB/Nlrp3 Signaling Pathway

Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis

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