Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner

Xu, Feng; Zhong, Jia‐Yu; Lin, Xiao; Shan, Su-Kang; Guo, Bei; Zheng, Minghui; Wang, Yi; Li, Fuxingzi; Cui, Rongrong; Wu, Feng; Zhou, Enbo; Liao, Xiao‐Bo; Liu, You‐Shuo; Yuan, Ling‐Qing

doi:10.1111/jpi.12631

Cited by 120 publications

(83 citation statements)

References 53 publications

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“…Through interference with ATS progression, melatonin also possibly contributes to slower development of ischemic heart disease [ 127 ]. Moreover, it inhibits calcium accumulation, leucocyte infiltration, and endothelial damage [ 167 , 168 ]. In addition, it has antithrombotic effects through a reduction in platelet reactivity [ 129 ].…”

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies.

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Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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“…For instance Li et al reported that exosomes derived from high glucose induced endothelial cells could carry versican protein to accelerate VSMCs calci cation [9]. Our previous study demonstrated that melatonin alleviated vascular calci cation through an exosomal miR-204/miR-211 cluster in a paracrine manner [11]. However, the role and mechanism of exosomes in regulating vascular calci cation in patients with ESRD is not very clear.…”

Section: Introductionmentioning

confidence: 97%

Plasma exosomes derived from patients with end-stage renal disease and renal transplant recipients have different effects on vascular calcification

Lin

Zhu²,

Xing³

et al. 2020

Preprint

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Background End-stage renal disease (ESRD) patients usually develop extensive and progressive vascular calcification, and lots of calcification inhibitors as well as pro-calcifying factors are involved in the process. However, the mechanisms of vascular calcification in ESRD patients are still ill-defined. Methods The participants in the study were selected at the Second Xiangya Hospital, Central South University, and the plasma exosomes derived from ESRD patients (ESRD-Ex), renal transplant recipients (RTR-Ex), and the normal health control group (Nor-Ex) were isolated by ExoQuick-TC kit. Transmission electron microscopy and molecular size analysis were used to assess the morphology and size of exosomes. Alizarin Red S staining was carried out to detect calcification of vascular smooth muscle cells (VSMCs). Protein levels of Fetuin-A, matrix gla protein (MGP), Annexin-A2, bone morphogenetic protein (BMP-2), and receptor activator for nuclear factor-κ B ligand (Rankl) were measured by Western Blot analysis and the contents of that were detected using ELISA. Coronary artery calcification scores (CACS) were quantified via Agaston and analysed by Siemens CaScoring software. Results Compared with Nor-Ex, the ESRD-Ex promoted calcification of VSMCs significantly, and RTR-Ex could attenuate VSMCs calcification. Moreover, the protein concentration of ESRD-Ex was significantly higher than Nor-Ex and RTR-Ex, and the content of both MGP and Fetuin-A, the calcification inhibitors, were prominently lower in ESRD-Ex than those in Nor-Ex. The content of Annexin-A2, one of the calcification promoters, was significantly higher in ESRD-Ex and RTR-Ex than that in Nor-Ex. But, BMP-2 and Rankl had no significant difference among the three groups. In addition, the content of Fetuin-A in RTR-Ex was higher than that in ESRD-Ex, though it was still lower than in Nor-Ex. Furthermore, the content of both plasma Fetuin-A and MGP were negatively while that of Annexin-A2 was negatively correlated to CACS. Conclusions These results indicated that ESRD-Ex significantly promoted VSMCs calcification while renal transplantation could partially attenuate the effect of exosomes. Fetuin-A and MGP were decreased but Annexin-A2 was increased in ESRD-Ex, and renal transplantation could increase the level of Fetuin-A rather than MGP.

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“…Exosomes play a role in cardiovascular system as well. Our present study investigated that exosomes derived from melatonin-treated vascular smooth muscle cells could mitigate vascular calcification and aging through an exosomal miR-204/miR-211 cluste [31]. Cheng et al proposed a mechanism whereby miRNAs enveloped in impaired myocardium-derived exosomes can be selectively transferred into bone marrow cells to mobilise progenitor cell migration to lesions, promoting heart tissue repair [30].…”

Section: E Function Of Exosomesmentioning

confidence: 91%

Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease

Wang

Zhong

et al. 2020

International Journal of Endocrinology

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Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell, reflecting a novel physiological and pathological mechanism in disease development. As a transmitter, exosomes shuttle to different cells or tissues and mediate communications among these organelles. To date, several studies have demonstrated that exosomes play crucial roles in disease pathogenesis and development, such as breast and prostate cancer. However, studies investigating connections between exosomes and thyroid disease are limited. In this review, recent research advances on exosomes in thyroid cancer and Graves’ disease are reviewed. These studies suggest that exosomes are involved in thyroid disease and appear as impressive potentials in thyroid therapeutic areas.

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Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner

Cited by 120 publications

References 53 publications

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Plasma exosomes derived from patients with end-stage renal disease and renal transplant recipients have different effects on vascular calcification

Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease

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