Melatonin and age‐related cardiovascular diseases

Zhong, Jia‐Yu; Liu, You‐Shuo

doi:10.1002/agm2.12036

Cited by 12 publications

(9 citation statements)

References 84 publications

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“…It exists in many organisms, and its content changes over time ( Zisapel, 2018 ). Melatonin is involved in regulating various processes in the human body, including blood pressure, core temperature, sleep, gastrointestinal physiology, anti-inflammatory function, and cardiovascular function ( Xie et al, 2017 ; Yin et al, 2018 ; Zhong and Liu, 2018 ; Hardeland, 2019 ; Chitimus et al, 2020 ). Notably, postmenopausal women are prone to osteoporosis, and they often have a low melatonin level ( Blaicher et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Melatonin Mediates Osteoblast Proliferation Through the STIM1/ORAI1 Pathway

et al. 2022

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Based on the positive correlation between bone mineral density and melatonin levels in blood, this study confirmed that melatonin supplementation prevents postmenopausal osteoporosis. We further confirmed that melatonin promotes an increase in intracellular calcium concentrations through the STIM1/ORAI1 pathway, thereby inducing the proliferation of osteoblasts.Introduction: Osteoporosis (OP) is a progressive, systemic bone disease that is one of the main causes of disability and death in elderly female patients. As an amine hormone produced by the human pineal gland, melatonin plays an important role in regulating bone metabolism. This study intends to investigate the relationship between melatonin levels in human blood and bone density and to suggest the efficacy of melatonin in treating osteoporosis by performing in vivo and in vitro experiments.Methods: We used liquid chromatography-tandem mass spectrometry to determine the serum melatonin levels in postmenopausal women with osteoporosis and young women with a normal bone mass. The bone density, BV/TV, Tb.Th, Tb.Sp and other indicators of postmenopausal osteoporosis and mice with a normal bone mass were detected by measuring bone density and micro-CT. The intracellular calcium ion concentration was detected using fluorescence microscopy and a full-wavelength multifunctional microplate reader, and the expression of SOCE-related genes and STIM1/ORAI1 proteins was detected using PCR and WB.Results: This study confirmed that bone density positively correlates with the melatonin level in human blood. In the animal model, melatonin supplementation reverses postmenopausal osteoporosis. We explored the internal mechanism of melatonin treatment of osteoporosis. Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation.Conclusions: This study provides an important theoretical basis for the clinical application of melatonin in patients with osteoporosis and helps to optimize the diagnosis and treatment of postmenopausal osteoporosis.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Melatonin Mediates Osteoblast Proliferation Through the STIM1/ORAI1 Pathway

et al. 2022

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“…During aging, melatonin therapy also ameliorates the function of muscular mitochondrial integrity, retrieves cardiac mitochondria from several defects [ 29 ], and restores its structural architecture [ 30 , 31 ]. Recently, the relation between melatonin secretion and muscular strength during aging, in addition to its role against age-related cardiovascular diseases, has been reported [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

et al. 2021

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To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin therapy. The results clarified the beginning of the cardiac sarcopenia at the age of 12 months, with hypertrophy of cardiac myocytes, increased expression of β-MHC, appearance of small necrotic fibers, decline of cadiomyocyte number, destruction of mitochondrial cristae, appearance of small-sized residual bodies, and increased apoptotic nuclei ratio. These changes were progressed in the cardiac myocytes of 24 old mice, accompanied by excessive collagen deposition, higher expressions of IL-1α, IL-6, and TNFα, complete mitochondrial vacuolation and damage, myofibrils disorganization, multivesicular bodies formation, and nuclear fragmentation. Interestingly, cardiac myocytes of NLRP3−/− mice showed less detectable age-related changes compared with WT mice. Oral melatonin therapy preserved the normal cardiomyocytes structure, restored cardiomyocytes number, and reduced β-MHC expression of cardiac hypertrophy. In addition, melatonin recovered mitochondrial architecture, reduced apoptosis and multivesicular bodies’ formation, and decreased expressions of β-MHC, IL-1α, and IL-6. Fewer cardiac sarcopenic changes and highly remarkable protective effects of melatonin treatment detected in aged cardiomyocytes of NLRP3−/− mice compared with aged WT animals, confirming implication of the NLRP3 inflammasome in cardiac aging. Thus, NLRP3 suppression and melatonin therapy may be therapeutic approaches for age-related cardiac sarcopenia.

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“…This phenomenon can be explained by the fact that the sebaceous glands do not belong to the structures of extrapineal synthesis of melatonin, in contrast to the keratinocytes of the skin and, therefore, sebocytes may be more sensitive to the exogenous hormone. According to studies on the effect of exogenous melatonin on rodents using various stress models, it was found that this hormone has a powerful and long-term anti-stress effect [9,17,23].…”

Section: Discussionmentioning

confidence: 99%

Effect of exogenous melatonin and flaxseed oil on the expression state of MT1 receptors in rat skin under light deprivation

2021

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Most of the skin cells have their own autonomous functional circadian system, which is able to control physiological and biochemical processes in the general integument. A special role in these processes is assigned to the “clock” hormone of the pineal gland, melatonin, which acts on target cells through specific receptors (MT1, MT2, MT3 and RORα). Any disturbance of circadian rhythms can lead to rearrangements (disturbances) in the receptor apparatus of the cells of the general cover, which require a certain correction. Consequently, there is a need to search for effective and reliable drugs that will prevent the negative consequences caused by chronodestruction. In the present work, we studied the effectiveness of the effect of exogenous melatonin and flaxseed oil on the expression of MT1 receptors in the general coat of rats under light deprivation. An experimental study was carried out on 130 white outbred male rats (170-220 g), which were randomly divided into 5 groups: intact, light deprivation animals, light deprivation animals, which were injected intragastrically with flaxseed oil and melatonin. On days 7, 14 and 21, histological material was taken (fragments of the skin of the interscapular region of the back). For immunohistochemical studies, serial sections were stained using MTNR1A polyclonal antibodies. For morphometric data analysis, the Image Scope Color and ImageJ computer programs were used. All statistical data processing was performed using the Statistica 10.0 software. Differences were considered significant at a significance level of less than 0.01 (p <0.01). In the course of the experiment, it was found that light deprivation contributes to a change in the activity of expression of the MT1 melatonin receptors in the epidermis, sebaceous glands and hair follicles. Studies have shown that the administration of flaxseed oil, melatonin, and their combination to rats with desynchronosis is accompanied by the leveling of the adverse effect of desynchronosis on the studied parameters of MT1 receptors. The most pronounced corrective effect on the expression of MT1 receptors is observed with the introduction of exogenous melatonin on the 21st day of the experiment.

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Melatonin and age‐related cardiovascular diseases

Cited by 12 publications

References 84 publications

RETRACTED: Melatonin Mediates Osteoblast Proliferation Through the STIM1/ORAI1 Pathway

RETRACTED: Melatonin Mediates Osteoblast Proliferation Through the STIM1/ORAI1 Pathway

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

Effect of exogenous melatonin and flaxseed oil on the expression state of MT1 receptors in rat skin under light deprivation

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