Melatonin and epilepsy

Jones, Carolyn M.; Huyton, M; Hindley, Daniel

doi:10.1136/adc.2005.077172

Cited by 25 publications

(12 citation statements)

References 4 publications

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“…Lately, the use of melatonin has become increasingly popular to facilitate induction of sleep in both children and adults [2,4,9,10,15,16,18,19]. Melatonin (5-methoxy-N-acetyltraptamine) is a pineal hormone; its synthesis is controlled by external factors including environmental light.…”

Section: Discussionmentioning

confidence: 99%

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Melatonin does not influence sleep deprivation electroencephalogram recordings in children

et al. 2011

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Section: Discussionmentioning

confidence: 99%

“…Moreover, melatonin has been recommended for use in children with epilepsy since it has been shown to improve the quantity and quality of sleep, thus reducing the probability of sleep deprivation induced seizures in these patients [9,10]. Animal research has demonstrated that melatonin suppresses epileptic discharges [5,20].…”

Section: Introductionmentioning

confidence: 98%

Melatonin does not influence sleep deprivation electroencephalogram recordings in children

et al. 2011

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“…Andersen et al (2008) did not find any worsening of epilepsy control. Research into effects on epilepsy has been contradictory; Sheldon (1998) and Coppola et al (2004) found worsening of seizures while others (Jones et al 2005;Elkhavat et al 2010) found improvement.…”

Section: Discussionmentioning

confidence: 93%

Use of melatonin for sleep disturbance in a large intellectual disability psychiatry service

Ward

Nanjappa

Hinder

et al. 2014

International Journal of Developmental Disabilities

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“…Melatonin has also been used in doses of 2 -10 mg before bedtime to treat sleep disturbances in children with epilepsy. Melatonin treatment was associated with an increase in seizure frequency in some patients and a decrease in others (Jones et al, 2005;Sheldon, 1998). Because melatonin appears to have unpredictable effects on seizure frequency, it should be used with caution in patients with epilepsy.…”

Section: Hormones Melatoninmentioning

confidence: 99%

Role of certain nutritional supplements and biological regulators in the epilepsy

Asif¹

2013

TANG [HUMANITAS MEDICINE]

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Certain dietary contents, biological supplements might influence the occurrence or treatment of epilepsy. Some studies have found that the supplementation with individual nutrients reduced seizure frequency or improved other aspects of health in patients with epilepsy. Potentially beneficial dietary interventions include treating blood glucose dysregulations. Identifying and avoiding allergenic foods, and avoiding suspected triggering agents such as alcohol, aspartame, and monosodium glutamate. The Atkins diet (very low in carbohydrates) is a less restrictive type diet that may be effective in some cases. Nutrients that may reduce seizure frequency include vitamin B6, magnesium, vitamin E, manganese, taurine, dimethylglycine, and omega-3 fatty acids. Administration of thiamine may improve cognitive function in patients with epilepsy. Supplementation with folic acid, vitamin B6, biotin, vitamin D, and L-carnitine may be needed to prevent or treat deficiencies resulting from the use of anticonvulsant drugs. Vitamin K1 has been recommended near the end of pregnancy for women taking anticonvulsants. Melatonin may reduce seizure frequency in some cases, and progesterone may be useful for women with cyclic exacerbations of seizures. In most cases, nutritional therapy is not a substitute for anticonvulsant medications. However, in selected cases, depending on the effectiveness of the interventions, dosage reductions or discontinuation of medications may be possible. However, nutrient supplementation may be necessary to prevent or reverse the effects of certain deficiencies that frequently result from the use of antiepileptic drugs.

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Melatonin and epilepsy

Cited by 25 publications

References 4 publications

Melatonin does not influence sleep deprivation electroencephalogram recordings in children

Melatonin does not influence sleep deprivation electroencephalogram recordings in children

Use of melatonin for sleep disturbance in a large intellectual disability psychiatry service

Role of certain nutritional supplements and biological regulators in the epilepsy

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