Melatonin and healthy aging

Cardinali, Daniel P.

doi:10.1016/bs.vh.2020.12.004

Cited by 47 publications

(37 citation statements)

References 83 publications

(105 reference statements)

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“…Melatonin is a highly studied biomolecule due to its known role in mammals as a regulating hormone of sleep-wake cycles, and other functions in endogenous rhythms, mood, metabolism, and immunological responses [9,10]. In addition, it has been investigated as to its therapeutic efficacy in Alzheimer's disease, Parkinsonism, cancer, diabetes, and SARS-CoV-2 [11][12][13][14][15][16][17].…”

Section: Biosynthesis Of Melatonin In Plantsmentioning

confidence: 99%

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Melatonin and Carbohydrate Metabolism in Plant Cells

Arnao

Hernández‐Ruíz

Caño

et al. 2021

Plants

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Melatonin, a multifunctional molecule that is present in all living organisms studied, is synthesized in plant cells in several intercellular organelles including in the chloroplasts and in mitochondria. In plants, melatonin has a relevant role as a modulatory agent which improves their tolerance response to biotic and abiotic stress. The role of melatonin in stress conditions on the primary metabolism of plant carbohydrates is reviewed in the present work. Thus, the modulatory actions of melatonin on the various biosynthetic and degradation pathways involving simple carbohydrates (mono- and disaccharides), polymers (starch), and derivatives (polyalcohols) in plants are evaluated. The possible applications of the use of melatonin in crop improvement and postharvest products are examined.

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Section: Biosynthesis Of Melatonin In Plantsmentioning

confidence: 99%

“…Plants 2021, 10, x FOR PEER REVIEW 2 of 14 tions in endogenous rhythms, mood, metabolism, and immunological responses [9,10]. In addition, it has been investigated as to its therapeutic efficacy in Alzheimer's disease, Parkinsonism, cancer, diabetes, and SARS-CoV-2 [11][12][13][14][15][16][17].…”

Section: Biosynthesis Of Melatonin In Plantsmentioning

confidence: 99%

Melatonin and Carbohydrate Metabolism in Plant Cells

Arnao

Hernández‐Ruíz

Caño

et al. 2021

Plants

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“…Melatonin (N-acetyl-5-methoxytryptamin, aMT) is a hormone that is synthesized in the pineal gland and is also vastly produced by various body organs and tissues [ 21 ]. Besides the chronobiotic properties of pineal melatonin, the extrapineal melatonin exerts a regulatory role in autophagy, cell cycle and apoptosis, mitochondria homeostasis, and acts as an immunomodulatory, free scavenger, and cytoprotective agent with anti-inflammatory and anti-oxidative features [ 22 , 23 , 24 , 25 , 26 , 27 ]. Melatonin administration improves muscular function, reduces oxidative stress, and inflammation in athletes [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

et al. 2021

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To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin therapy. The results clarified the beginning of the cardiac sarcopenia at the age of 12 months, with hypertrophy of cardiac myocytes, increased expression of β-MHC, appearance of small necrotic fibers, decline of cadiomyocyte number, destruction of mitochondrial cristae, appearance of small-sized residual bodies, and increased apoptotic nuclei ratio. These changes were progressed in the cardiac myocytes of 24 old mice, accompanied by excessive collagen deposition, higher expressions of IL-1α, IL-6, and TNFα, complete mitochondrial vacuolation and damage, myofibrils disorganization, multivesicular bodies formation, and nuclear fragmentation. Interestingly, cardiac myocytes of NLRP3−/− mice showed less detectable age-related changes compared with WT mice. Oral melatonin therapy preserved the normal cardiomyocytes structure, restored cardiomyocytes number, and reduced β-MHC expression of cardiac hypertrophy. In addition, melatonin recovered mitochondrial architecture, reduced apoptosis and multivesicular bodies’ formation, and decreased expressions of β-MHC, IL-1α, and IL-6. Fewer cardiac sarcopenic changes and highly remarkable protective effects of melatonin treatment detected in aged cardiomyocytes of NLRP3−/− mice compared with aged WT animals, confirming implication of the NLRP3 inflammasome in cardiac aging. Thus, NLRP3 suppression and melatonin therapy may be therapeutic approaches for age-related cardiac sarcopenia.

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“…Because of its rhythmic diur-nal fluctuations MT is considered as main body regulator of circadian rhythms. Production of this indoleamine decreases with age, and its diurnal rhythm of secretion disappears in older individuals [31].…”

Section: Introductionmentioning

confidence: 98%

Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis–A New Look on an Old Story–A Review

Jaworek¹,

Szepietowski²,

Hałubiec³

et al. 2021

Preprint

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Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in the patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possess strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with focus on the antioxidant and immunomodulatory effects of MT.

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Melatonin and healthy aging

Cited by 47 publications

References 83 publications

Melatonin and Carbohydrate Metabolism in Plant Cells

Melatonin and Carbohydrate Metabolism in Plant Cells

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis–A New Look on an Old Story–A Review

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