Melatonin and Immunomodulation: Connections and Potential Clinical Applications

Giannoulia-Karantana, Aglaia; Vlachou, Antonia; Polychronopoulou, Sophia; Papassotiriou, Ioannis; Chrousos, George P.

doi:10.1159/000097258

Cited by 43 publications

(25 citation statements)

References 142 publications

(74 reference statements)

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“…Apart from its direct ROS-scavenging activity, it also increases the expression of antioxidant defense system enzymes such as superoxide dismutase (SOD), catalase, and the glutathione (GSH) system [16,17] . The anti-inflammatory properties of melatonin have been reported in several studies [18,19] . Its protective effects against cognitive dysfunction have been reported in several animal studies [20][21][22] .…”

mentioning

confidence: 91%

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Shen¹,

Tian²,

Sang³

et al. 2016

Neuroimmunomodulation

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Objectives: This study was intended to investigate whether treatment with resveratrol and melatonin alone or in combination can exert neurorestorative effects in a rat model of vascular dementia. Methods: Briefly, male Wistar rats were subjected to permanent bilateral common carotid artery occlusion (BCCAO) by surgery. After 4 weeks, the cognitive deficits were assessed using the Morris water maze and novel object recognition tests. The biochemical parameters of oxidative stress and inflammation were also assessed. Results: Rats in the BCCAO group showed cognitive deficits, accompanied by oxidonitrosative stress, neuroinflammation, and a reduction in brain-derived neurotrophic factor (BDNF) in the hippocampus region. Moreover, the acetylcholinesterase activity in the hippocampus was found to be increased in the BCCAO group compared to the sham group. The 4-week treatment with melatonin (10 mg/kg) and resveratrol (20 mg/kg) alone and in combination (melatonin 5 mg/kg and reseveratrol 10 mg/kg) caused a significant improvement in the cognitive deficits induced by BCCAO, accompanied by a reversal of oxidonitrosative stress, neuroinflammation, and BDNF depletion in the hippocampus region. Additionally, the treatment with melatonin and resveratrol significantly decreased acetylcholinesterase activity compared to in the BCCAO group. Melatonin and resveratrol ameliorated the BDNF expression of hippocampal protein. Conclusion: These results emphasize that coadministration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia through changes in BDNF expressions.

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mentioning

confidence: 91%

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Shen¹,

Tian²,

Sang³

et al. 2016

Neuroimmunomodulation

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“…The regression or healing of viral infections may be related to the fact that melatonin possesses immunomodulatory, antioxidative and antiinflammatory properties [19][20][21][22]. Also, it has been shown to be beneficial in virus infection [18,27].…”

Section: Discussionmentioning

confidence: 99%

“…SB‐73, a mixture of magnesium, phosphate, fatty acids and protein extracted from Aspergillus oryzae ; this formulation has anti‐herpes virus activity [10, 11, 13–15], but it has slight adverse effects which were eliminated when melatonin was added. The potential ability of melatonin to act synergistically with several other medications by enhancing their activity and reducing their adverse effects has placed melatonin among the new and promising agents in immunotherapy [19–22].…”

Section: Introductionmentioning

confidence: 99%

“…Odilon da Silva Nunes (in memoriam) and Ricardo de Souza Pereira has slight adverse effects which were eliminated when melatonin was added. The potential ability of melatonin to act synergistically with several other medications by enhancing their activity and reducing their adverse effects has placed melatonin among the new and promising agents in immunotherapy [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Regression of herpes viral infection symptoms using melatonin and SB‐73: comparison with Acyclovir

Nunes

Pereira

2008

Journal of Pineal Research

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Infection with Herpes simplex virus type 1 (HSV-1) typically causes lesions of the mouth, face, skin, esophagus, or brain. Herpes simplex virus type 2 (HSV-2) usually causes infections of the genitals, rectum, skin, hands, or meninges. The herpes viruses are a major cause of blindness from keratitis. The usual drugs used for herpes are Vidarabine, Acyclovir, Penciclovir and Ganciclovir; they are associated with several complications. The aim of this study was to investigate if a formulation containing 2.5 mg melatonin and 100 mg SB-73 would help patients with herpes, and to compare the preparation with 200 mg Acyclovir. SB-73 is a mixture of magnesium, phosphate, fatty acids extracted from Aspergillus sp. which has anti-herpes virus properties. A single blind randomized study was performed in which 70 patients underwent treatment using the supplement cited above (group A) and 75 received treatment of 200 mg Acyclovir (group B). Sixty-seven patients of the group A (95.7%) reported a complete regression of symptoms after 7 days of treatment. By comparison, 64 subjects (85.3%) of the Acyclovir reported regression of symptoms in the same period. There was statiscally significant difference between the groups (P < 0.05).

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“…Administration of the hormone in humans may contribute to the management of jet lag [Herxheimer and Petrie, 2002], the disorder observed after transatlantic flights. The hormone is involved in the regulation of the immune system [Giannoulia-Karantana et al 2006] and is a potent antioxidant agent [Tan et al 2007]. Μelatonin may contribute to the conservation of DNA integrity and may thus be involved in cancer prevention.…”

Section: Melatoninmentioning

confidence: 99%

Therapeutic applications of melatonin

Kostoglou-Athanassiou

2013

Therapeutic Advances in Endocrinology

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Melatonin is a methoxyindole synthesized within the pineal gland. The hormone is secreted during the night and appears to play multiple roles within the human organism. The hormone contributes to the regulation of biological rhythms, may induce sleep, has strong antioxidant action and appears to contribute to the protection of the organism from carcinogenesis and neurodegenerative disorders. At a therapeutic level as well as in prevention, melatonin is used for the management of sleep disorders and jet lag, for the resynchronization of circadian rhythms in situations such as blindness and shift work, for its preventive action in the development of cancer, as additive therapy in cancer and as therapy for preventing the progression of Alzheimer's disease and other neurodegenerative disorders.

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Melatonin and Immunomodulation: Connections and Potential Clinical Applications

Cited by 43 publications

References 142 publications

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Regression of herpes viral infection symptoms using melatonin and SB‐73: comparison with Acyclovir

Therapeutic applications of melatonin

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