Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain

Chunchai, Titikorn; Pintana, Hiranya; Arinno, Apiwan; Ongnok, Benjamin; Pantiya, Patcharapong; Khuanjing, Thawatchai; Prathumsap, Nanthip; Maneechote, Chayodom; Chattipakorn, Nipon; Chattipakorn, Siriporn C.

doi:10.1016/j.neuro.2022.11.012

Cited by 5 publications

(1 citation statement)

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“…Studies have also linked melatonin to the preservation of neural cells in the hippocampus [59], and the modification of dendritic morphology [60]. In line with these previous findings, our study has, for the first time, demonstrated that melatonin significantly prevents the reduction in dendritic spine density caused by cisplatin.…”

Section: Discussionsupporting

confidence: 90%

Melatonin mitigates cisplatin-induced cognitive impairment in rats and improves hippocampal dendritic spine density

Qutifan,

Saleh,

Abu Shahin

et al. 2024

NeuroReport

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Cisplatin-induced cognitive impairment (chemobrain) affects a considerable percentage of cancer patients and has no established pharmacological treatment. Chemobrain can be associated with neuroinflammation and oxidative stress. Melatonin, a pineal hormone, is known to have antioxidant, anti-inflammatory and neuroprotective potential. In this study, we investigated cisplatin-induced cognitive impairment in rats and whether melatonin can improve or reverse this impairment. Behavioral testing involved measuring working memory using the novel location recognition test (NLRT) under conditions of cisplatin or cisplatin + melatonin treatment, followed by the collection of rats’ brains. The brains were subsequently stained with Golgi-Cox stain and then the hippocampus area CA3 of each one was examined, and dendritic spine density was calculated. Treatment with cisplatin resulted in deficits in the rats’ performance in the NLRT (P < 0.05). These deficits were prevented by the coadministration of melatonin (P < 0.05). Cisplatin also reduced the density of dendritic spines in the hippocampus (P < 0.0001), specifically CA3 area, while the coadministration of melatonin significantly reversed this reduction (P < 0.001). This study showed that melatonin can ameliorate cisplatin-induced spatial memory deficits and dendritic spines density abnormalities in rats. Given that melatonin is a safe and wildly used supplement, it is feasible to explore its use as a palliative intervention in cancer treatment.

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Section: Discussionsupporting

confidence: 90%