Melatonin and roentgen irradiation‐induced acute radiation enteritis in Albino rats: An animal model

Hussein, Mahmoud R.; Abu-Dief, Eman E.; Kamel, Esam S.; El-Ghait, Amal T. Abou; Abdulwahed, Saad Rezk; Ahmad, Mohamed

doi:10.1016/j.cellbi.2008.08.001

Cited by 21 publications

(18 citation statements)

References 19 publications

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“…Melatonin [10,[22][23][24] and octreotide [25] are known to have antiproliferative, anti-ischemic, antioxidant, and antiedema effects. To the best of our knowledge, there are no prior studies in which the effects of these two agents have been compared in a model of radiation-induced intestinal injury.…”

Section: Discussionmentioning

confidence: 99%

“…Because movement was prevented, no anesthesia was used during irradiation. Animals in subgroups R, MR, and OR were exposed to a single 8-Gy dose of whole-body X-ray irradiation, a dose that has been shown to produce significant intestinal injury [10,16]. The dose was delivered with a 6 MV photon energy beam (Clinac Ò DBX, Varian Ò Medical Systems, Palo Alto, CA, USA) at a dose rate of 4 Gy/min and a source-to-skin distance of 100 cm.…”

Section: Irradiation Proceduresmentioning

confidence: 99%

“…1) [10]. Five separate microscopic fields were evaluated using light microscopy at 409 magnification, and histological parameters were recorded as mean values.…”

Section: Histological Evaluationmentioning

confidence: 99%

“…In 2008, Hussein et al demonstrated the radiation-induced morphological-micromorphological changes of the small intestine, as well as the protective effect of melatonin against the radiation enteritis in rats [10]. However, no randomized preclinical studies have compared the potency of melatonin and octreotide in protecting against radiation-induced intestinal injury.…”

Section: Introductionmentioning

confidence: 97%

“…Irradiation sets in motion a series of events in the intestinal mucosal cells, caused by inflammation attributable to leukocyte accumulation in the irradiated area and culminating in the loss of epithelial integrity [10]. The generation of oxidants plays an important role in the pathogenesis of radiation-induced tissue damage [11].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Irradiation Proceduresmentioning

confidence: 99%

“…1) [10]. Five separate microscopic fields were evaluated using light microscopy at 409 magnification, and histological parameters were recorded as mean values.…”

Section: Histological Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury

et al. 2010

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Melatonin as an anti-inflammatory agent in radiotherapy

et al. 2017

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Radiotherapy is one of the most relevant treatment options for cancer therapy with or without other treatment modalities including immunotherapy, surgery and chemotherapy. Exposure to heavy doses of ionizing radiation during radiotherapy results in short and long term side effects. It appears that many of these side effects are linked to inflammatory responses during treatment or after prolonged use. Inflammation is mediated by various genes and cytokines related to immune system responses caused by massive cell death following radiotherapy. This phenomenon is more obvious, particularly after exposure to clinical doses of radiotherapy. Inflammation is involved in the amplification of acute responses, genomic instability and also long term pathological changes in normal tissues. Moreover, inflammation attenuates responses of the tumor to radiotherapy through some mechanisms such as angiogenesis. Thus, the management of inflammation is one of the most interesting aims in cancer radiotherapy. Melatonin, known as a natural product in the body, has been of much interest for its anti-inflammatory properties. Some studies have proposed melatonin as a novel anti-inflammation agent. This literature review will concentrate on the anti-inflammatory properties of melatonin that may help the management of different inflammatory signaling pathways in both tumor and normal tissues.

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ER stress and genomic instability induced by gamma radiation in mice primary cultured glial cells

Chatterjee

Nairy²,

Langhnoja

et al. 2018

Metab Brain Dis

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Ionizing radiation induces various pathophysiological conditions by altering central nervous system (CNS) homeostasis, leading to neurodegenerative diseases. However, the potential effect of ionizing radiation response on cellular physiology in glial cells is unclear. In the present study, micronucleus test, comet assay, and RT-PCR were performed to investigate the potential effect of gamma radiation in cultured oligodendrocytes and astrocytes with respect to genomic instability, Endoplasmic Reticulum (ER) stress, and inflammation. Further, we studied the effect of alteration in ER stress specific gene expression in cortex post whole body radiation in mice. Results showed that exposure of gamma radiation of 2Gy in-vitro cultured astrocytes and oligodendrocytes and 7Gy in-vivo induced ER stress and Inflammation along with profuse DNA damage and Chromosomal abnormality. Additionally, we observed downregulation of myelin basic protein levels in cultured oligodendrocytes exposed to radiation. The present data suggests that ER stress and pro inflammatory cytokines serve as the major players in inducing glial cell dysfunction post gamma irradiation along with induction of genomic instability. Taken together, these results indicate that ER stress, DNA damage, and inflammatory pathways may be critical events leading to glial cell dysfunction and subsequent cell death following exposure to ionizing radiation.

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Melatonin and roentgen irradiation‐induced acute radiation enteritis in Albino rats: An animal model

Abstract: Administration of melatonin prior to irradiation can protect the intestine against X-rays destructive effects, i.e. radiation enteritis. The clinical applications of these observations await further studies.

Cited by 21 publications

References 19 publications

Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury

Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury

Melatonin as an anti-inflammatory agent in radiotherapy

ER stress and genomic instability induced by gamma radiation in mice primary cultured glial cells

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