Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

Takhtfooladi, Hamed Ashrafzadeh; Takhtfooladi, Mohammad Ashrafzadeh; Moayer, Fariborz; Mobarakeh, Sayed

doi:10.1016/j.rppnen.2014.01.010

Cited by 22 publications

(19 citation statements)

References 39 publications

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“…The results of this research clarified that I/R caused severe lung damage in the form of vascular congestion with subsequent hemosiderin deposition, massive inflammatory infiltrate, edema, emphysema, alveolar damage with thickened interalveolar septa and disrupted bronchial epithelium. These results were in agreement with other researches [14,15] that reported occurrence of acute lung injury following hind limb I/R in rats.…”

Section: Discussionsupporting

confidence: 94%

“…The period of the ischemia and subsequent reperfusion used in this study was based on previous studies that evaluated the lesions of remote organs [5,14,15] . The results of this research clarified that I/R caused severe lung damage in the form of vascular congestion with subsequent hemosiderin deposition, massive inflammatory infiltrate, edema, emphysema, alveolar damage with thickened interalveolar septa and disrupted bronchial epithelium.…”

Section: Discussionmentioning

confidence: 99%

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Possible protective effect of pomegranate peel powder on lung injury induced by skeletal muscle ischemia-reperfusion

Salama

Faried

2018

Egyptian Journal of Histology

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Introduction: Multi-organ failure with life-threatening sequel occurs in a variety of surgical practices as a result of ischemiareperfusion (I/R) injury. Aim of work: In this study, more light is thrown on the histological lung changes induced by skeletal muscle I/R with reference to their underlying mechanisms and to determine, for the first time, the protective role of pomegranate peel powder on the lung injury induced by skeletal muscle I/R. Materials and Methods: Thirty adult male albino rats were divided equally into three groups: sham control group, I/R group and I/R group pretreated with pomegranate peel powder (500 mg/kg dissolved in distilled water twice daily orally for 10 days). At the end of the experiment, blood samples were obtained to assess serum malondialdehyde (MDA) then lung specimens were processed for routine histological examination and detection of collagen deposition. Myeloperoxidase (MPO), a marker of neutrophils infiltration, transforming growth factor-β (TGF-β), an inflammatory and pro-fibrotic mediator and Bcl2, an anti-apoptotic marker, were detected immunohistochemically. Results: Loss of general architecture of the lung tissues, massive inflammatory infiltrate, emphysema, edema, congested blood vessels, thickened inter-alveolar septa, destruction of some alveoli, disorganization and focal sloughing of the bronchial epithelium in addition to increased collagen deposition were detected in I/R group. Oxidative stress in the form of significant increase of MDA level in addition to up-regulation of both MPO and TGF-β and down-regulation of Bcl2 were implicated in the pathogenesis of acute lung injury induced by skeletal muscle I/R. Pomegranate peel powder significantly ameliorated these damaging effects through its antioxidant, anti-inflammatory, anti-fibrotic and anti-apoptotic effects. Conclusion: Pretreatment of rats with pomegranate peel protected the lungs against skeletal muscle I/R injury.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Possible protective effect of pomegranate peel powder on lung injury induced by skeletal muscle ischemia-reperfusion

Salama

Faried

2018

Egyptian Journal of Histology

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“…The NO level in the rat lung was reported to be significantly increased by I/R and significantly decreased by melatonin. [25] In the present study, edaravone decreased the serum and tissue NO levels after I/R. Inflammatory mediators transported in blood from muscle tissue cause injury to distant organs, principally the lungs and kidneys.…”

Section: Discussionsupporting

confidence: 52%

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

İnce

Akar

Arıcı

2020

Turk Gogus Kalp Dama

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Akut alt ekstremite iskemi-reperfüzyon hasarında edaravonun renal koruyucu etkisi ÖZ Amaç: Bu deneysel çalışmada, sıçan modelinde akut alt ekstremite iskemi/reperfüzyonuna bağlı böbrek hasarında edaravonun etkinliği araştırıldı. Ça lış ma pla nı: Bu çalışmada Haziran 2015-Ağustos 2015 tarihleri arasında toplam 40 erkek Wistar sıçan kullanıldı. Sıçanlar sham, iskemi/reperfüzyon, edaravon ve solvent gruplarına randomize edildi (n=10 her bir grupta). İnfrarenal abdominal aort 120 dk. süreyle klemlendi ve sonrasında klemp kaldırılarak 120 dk. reperfüze edildi. İskemi indüksiyonundan 30 dk. önce edaravon intravenöz olarak verildi. Serum ve böbrek doku örnekleri biyokimyasal ve histopatolojik olarak analiz edildi. Bul gu lar: Edaravon serum ve doku malondialdehit düzeylerini iskemi/reperfüzyon grubunda azalttı. Serum süperoksit dismutaz aktivitesi, iskemi/reperfüzyon ve solvent gruplarına kıyasla, edaravon grubunda anlamlı düzeyde yüksekti. Serum nitrik oksit düzeyi iskemi/reperfüzyon grubunda, sham grubuna kıyasla, rakamsal olarak yüksek bulundu. Edaravon serum nitrik oksit düzeyini düşürdü. Serum nitrik oksit düzeyi edaravon grubunda, solvent grubundan, daha düşük idi. Doku nitrik oksit düzeyi iskemi/reperfüzyon grubunda, sham grubundan, anlamlı düzeyde daha yüksek idi. İskemi/ reperfüzyon grubunda histopatolojik değişikliklerde edaravon ile düzelme görüldü. So nuç: Edaravon alt ekstremite iskemi/reperfüzyonuna bağlı renal hasarı azalttı. Bu nedenle, aort ve periferik damar cerrahisinde akut iskemi/reperfüzyon hasarını hafifletmede kullanılabilir.

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“…Rat model of hind limb ischemia-reperfusion injury was conducted as previous report [22], and briefly hind limb I/R injury was induced by 6 h of femoral artery occlusion, followed by 24 h of reperfusion.…”

Section: Methodsmentioning

confidence: 99%

Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPK/NF-κB Pathways in Rats

Zhu

Cai

Zhou

et al. 2017

BioMed Research International

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Schisandrin B (ScB), isolated from Schisandra chinensis (S. chinensis), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects. However, it is unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model. In this study, ScB (20 mg/kg, 40 mg/kg, and 80 mg/kg) was administered via oral gavage once daily for 5 days before the surgery. After 6 h ischemia and 24 h reperfusion of left hind limb, ScB reduced I/R induced histological changes and edema. ScB also suppressed the oxidative stress through decreasing MDA level and increasing SOD activity. Moreover, above changes were associated with downregulated TNF-α mRNA expression and reduced level of IL-1β in plasma. Meanwhile, ScB treatment downregulated activation of p38MAPK, ERK1/2, and NF-κB in ischemic skeletal muscle. These results demonstrate that ScB treatment could prevent hind limb I/R skeletal muscle injury possibly by attenuating oxidative stress and inflammation via p38MAPK, ERK1/2, and NF-κB pathways.

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Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

Abstract: These findings suggest that melatonin has preventive effects in lung tissue injury after transient femoral artery occlusion.

Cited by 22 publications

References 39 publications

Possible protective effect of pomegranate peel powder on lung injury induced by skeletal muscle ischemia-reperfusion

Possible protective effect of pomegranate peel powder on lung injury induced by skeletal muscle ischemia-reperfusion

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPK/NF-κB Pathways in Rats

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