Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome

Wu, Hui-Mei; Xie, Qiu-Meng; Zhao, Cui-Cui; Xu, Jianming; Fan, Xiaoning; Zhang, Xu

doi:10.1016/j.lfs.2019.117067

Cited by 23 publications

(22 citation statements)

References 50 publications

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“…In a murine model of ovalbumin (OVA) induced allergic asthma, CpG-ODN (GpC-rich oligodeoxynucleotide) suppressed NLRP3 inflammasome activation and airway leukocytes infiltration, goblet cell hyperplasia and Th2 cytokines production (124). These effects by CpG-ODN were attributed to upregulation of melatonin synthetic enzymes, increased melatonin production, and abolished by the melatonin receptor antagonist, luzindole (124). Moreover, exogenous melatonin mimicked the anti-allergic actions of CpG-ODN (124).…”

Section: Melatonin On Innate and Adaptive Immunitymentioning

confidence: 99%

“…These effects by CpG-ODN were attributed to upregulation of melatonin synthetic enzymes, increased melatonin production, and abolished by the melatonin receptor antagonist, luzindole (124). Moreover, exogenous melatonin mimicked the anti-allergic actions of CpG-ODN (124). Actually, melatonin is known to be synthesized by mitochondria and these organelles are also important players in innate immunity and guardians of the inflammatory response (125).…”

Section: Melatonin On Innate and Adaptive Immunitymentioning

confidence: 99%

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Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Tan¹,

Hardeland²

2020

Melatonin Res.

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The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. Patients are vulnerable and mortality usually occurs during this window period. To control the innate immune response and reduce the inflammation during this period will increase the tolerance of patients and lowers the mortality in the deadly virus infection. Melatonin is a molecule that displays respective properties, since it downregulates the overreaction of the innate immune response and overshooting inflammation, but also promotes the adaptive immune activity. Many studies have reported the beneficial effects of melatonin on deadly virus infections in different animal models and its therapeutic efficacy in septic shock patients. Furthermore, melatonin has a great safety margin without serious adverse effects. We suggest the use of melatonin as an adjunctive or even regular therapy for deadly viral diseases, especially if no efficient direct anti-viral treatment is available.

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Section: Melatonin On Innate and Adaptive Immunitymentioning

confidence: 99%

Section: Melatonin On Innate and Adaptive Immunitymentioning

confidence: 99%

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Tan¹,

Hardeland²

2020

Melatonin Res.

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“…Knowing the anti-inflammatory capacity of melatonin, we urge the rational use of this substance for ALI/ARDS-mediated symptoms. Indeed, the melatonin-controlled regulation of NLRP3 was shown in radiation-induced lung injury or respiratory disturbances, where melatonin distinctly reduced the infiltration of macrophages and neutrophils into the lung by inhibition of the NLRP3 inflammasome [26,[57][58][59].…”

Section: Melatonin and Immunomodulationmentioning

confidence: 99%

Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed

et al. 2020

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The recent pandemic of COVID-19 has already infected millions of individuals and has resulted in the death of hundreds of thousands worldwide. Based on clinical features, pathology, and the pathogenesis of respiratory disorders induced by this and other highly homogenous coronaviruses, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response contribute to COVID-19 pathology; these are caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This leads to a cytokine storm and subsequent progression triggering acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), and often death. We and others have reported melatonin to be an anti-inflammatory and anti-oxidative molecule with a high safety profile. It is effective in critical care patients by reducing their vascular permeability and anxiety, inducing sedation, and improving their quality of sleep. As melatonin shows no harmful adverse effects in humans, it is imperative to introduce this indoleamine into clinical trials where it might be beneficial for better clinical outcomes as an adjuvant treatment of COVID-19-infected patients. Herein, we strongly encourage health care professionals to test the potential of melatonin for targeting the COVID-19 pandemic. This is urgent, since there is no reliable treatment for this devastating disease.

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“…Based on the strong evidences on the role of OS, a balance of free radicals by exogenous antioxidants are the first lines of choice to maintain a proper physiological function in chronic restraint stress, that it is primarily a psychological stressor model. Melatonin hormone, which is secreted mainly at night to maintain sleep-wake rhythm, also has an endogenous antioxidant with anti-inflammatory properties that controls insomnia, reduces anxiety, and stimulates immunity (9,10). Melatonin has been shown to relieve acute respiratory stress caused by viruses, bacteria, and radiation and can help decrease lung fibrosis, which is a significant complication of SARS-CoV-2 (11,12).…”

Section: Introductionmentioning

confidence: 99%

“…Bats, which were thought to be the primary cause of COVID-2 spread, have high levels of melatonin while they themselves do not suffer with the disease (13). Melatonin can also inhibit the SARS-CoV-2 activated inflammasomes like NLRP3, which triggers the sequence of cytokine storm that is responsible for extreme lung inflammation, injury, and acute respiratory distress syndrome (9,12).…”

Section: Introductionmentioning

confidence: 99%

Possible Prophylactic Approach for SARS-CoV-2 Infection by Combination of Melatonin, Vitamin C and Zinc in Animals

et al. 2020

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SARS-CoV-2, an epidemic, causes severe stress in both human and animals and may induce oxidative stress (OS) and increases susceptibility to infection. Domestic animals are found infected by their COVID-2 suffering owners. Chronic immobilization stress (CIS), a model of psychological and physical stress of confinement, can trigger depression and anxiety in animals. We evaluated the ameliorative effect of the proposed SARS-CoV-2 prophylactic drugs melatonin, vitamin C, and zinc on CIS-induced OS, inflammation, and DNA damage in rats. Forty male Swiss albino rats (200–250 g, 7–9 weeks old) were divided into five groups as controls, CIS, treated with melatonin (20 mg/kg), and vitamin C plus zinc [VitC+Zn (250 + 2.5 mg/kg)] alone or in combination (melatonin+VitC+zinc) subjected to CIS for 3 weeks. CIS was induced by immobilizing the whole body of the rats in wire mesh cages of their size with free movement of head. Exposure to CIS significantly compromised the circulatory activities of superoxide dismutase, catalase, and glutathione with enhanced malondialdehyde, inflammatory markers (IL-6, IL10, and TNFα), and lymphocyte DNA damage in comparison to controls. Treatment with melatonin and VitC+Zn alone or in combination significantly restored the altered biochemical parameters and DNA damage of stressed rats to their respective control values. However, the cumulative action of melatonin with VitC+Zn was more effective in alleviating the CIS-induced OS, inflammation, and DNA damage. The present study indicates that the antioxidant combination can be an effective preventive measure to combat severe psychological and confinement stress-induced biochemical changes in animals due to abnormal conditions such as SARS-CoV-2.

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Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome

Cited by 23 publications

References 50 publications

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed

Possible Prophylactic Approach for SARS-CoV-2 Infection by Combination of Melatonin, Vitamin C and Zinc in Animals

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