Melatonin blocks the stimulatory effects of prolactin on human breast cancer cell growth in culture

Lemus-Wilson, Athena; Kelly, P. A.; De, Blask

doi:10.1038/bjc.1995.526

Cited by 45 publications

(19 citation statements)

References 24 publications

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“…Melatonin shows antigonadotropic and antioestrogenic actions in different study module, in vitro and in vivo on hormone-dependent tumours and cancer cell line [44] as well as antagonised the action of prolactin on human breast cancer cell (HBC) [54]. It selectively neutralised the effects of estrogens on the breast and the local biosynthesis of estrogens from androgens [55].…”

mentioning

confidence: 99%

An insight into the scientific background and future perspectives for the potential uses of melatonin

Anwar

Muhammad²,

Bader³

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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Antiepileptic Antiosteoporotic Antioxidant Cardiovascular disease Circardian rhythm Hypnotic Immunodulatory Melatonin a b s t r a c t Melatonin is one of the most versatile and ubiquitous molecule widely distributed in nature has been reported to play a role in a wide variety of physiological responses including reproduction, circadian homeostasis, sleep, retinal neuromodulation, and vasomotor responses. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light ⁄ dark cycle via the suprachiasmatic nucleus. Melatonin is synthesized in all areas of the body such as gastrointestinal tract, skin, bone marrow, retina and in lymphocytes, from which it may influence other physiological functions through paracrine signalling. In addition to regulation of circadian rhythm of melatonin a variety of other physiological effects such as hypnotic, antidepressant, antiepileptic, oncostatic, immunomodulatory, antiosteoporotic, in cardiovascular disease, neuromodulatory and cerebral ischaemic condition have been reported.Moreover there is scarcity of literature that reviewed the scientific evidence for its use in these conditions. Therefore in this article we review recent advances in this research field, which is preceded by a concise account of general information about melatonin, melatonin receptors and intracellular signalling pathways for melatonin actions.

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mentioning

confidence: 99%

An insight into the scientific background and future perspectives for the potential uses of melatonin

Anwar

Muhammad²,

Bader³

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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“…Furthermore, melatonin was shown to lose its antimitogenic properties in serum-free medium unless cells are also simultaneously exposed to estradiol [92], epidermal growth factor [93] or prolactin [94].…”

Section: Oncostatic Role Of Melatoninmentioning

confidence: 99%

Melatonin Involvement in Immunity and Cancer

Fraschini¹,

Demartini²,

Esposti³

et al. 1998

Neurosignals

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The most studied endocrine product of the pineal gland, melatonin, has been reported to be involved in the feedback between neuroendocrine and immune functions and to exert oncostatic action, at least in certain experimental conditions. Melatonin seems to be an integral part of the immune system, by exerting direct and/or indirect stimulatory effects on both cellular and humoral immunity. Likewise, an antitumor activity of melatonin has been shown in several experimental models in vivo and in vitro. The means by which melatonin exerts its effects on immunity and neoplastic growth have not been elucidated. The different putative mechanisms of action of melatonin investigated so far are here briefly discussed.

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“…Although some recent studies have reported melatonin oncostatic activity in human breast cancer cell lines in vitro [93], very little is known about the clinical use of melatonin in breast cancer patients [94]. In a similar manner, the evidence for a role of melatonin in the management of patients with metastatic solid tumors remains insufficient.…”

Section: Melatonin the Immune System And Cancermentioning

confidence: 98%

Melatonin: A clinical perspective

Penev

Zee

1997

Annals of Neurology

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Over the last several decades the pineal gland has emerged as an active neuroendocrine transducer of important environmental information. However, the current understanding of the function of its major hormone, melatonin, in humans remains ill defined and based exclusively on correlative observations. In a similar manner, the multitude of phenomenological descriptions of the effects of exogenous melatonin is contrasted by the limited understanding of the underlying mechanisms and the lack of firmly established clinical applications for the hormone. Future randomized, double-blind, placebo-controlled clinical studies will be necessary to determine the precise indications, treatment regimens, and safety of melatonin in clinical practice. The recent rapid progress in the area of melatonin research should lead to a better understanding of its role in human health and disease.

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Melatonin blocks the stimulatory effects of prolactin on human breast cancer cell growth in culture

Cited by 45 publications

References 24 publications

An insight into the scientific background and future perspectives for the potential uses of melatonin

An insight into the scientific background and future perspectives for the potential uses of melatonin

Melatonin Involvement in Immunity and Cancer

Melatonin: A clinical perspective

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