Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases

Yılmaz, Bülent; Kılıç, Sevtap; Aksakal, Orhan; Ertaş, İbrahim Egemen; Tanrisever, Gonca Gul; Aksoy, Yasemin; Lortlar, Neşe; Kelekçi, Sefa; Güngör, Tayfun

doi:10.1007/s00404-014-3599-4

Cited by 31 publications

(41 citation statements)

References 42 publications

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“…56 Additionally, EMS is strongly associated with chronic pelvic pain (EACPP), which presents with an intense inflammatory reaction. 66 In another study, different doses of melatonin treatment on endometrial implants (10 or 20 mg/kg/day) resulted in the regression of endometriotic lesions by improving histologic scores in the oophorectomized rat experimental models. 62 In addition, melatonin induces apoptosis and regresses endometriosis through a caspase-3 mediated pathway.…”

Section: Mel Atonin and Endome Tri Os Ismentioning

confidence: 96%

“…Activity of SOD and TIMP-2 staining in melatonin group was significantly higher, while there were significant reductions in implant levels of vascular endothelial growth factor (VEGF) and MMP-9 in melatonin group than control group. 66 In another study, different doses of melatonin treatment on endometrial implants (10 or 20 mg/kg/day) resulted in the regression of endometriotic lesions by improving histologic scores in the oophorectomized rat experimental models. And higher levels of melatonin treatment tend to be more effective.…”

Section: Mel Atonin and Endome Tri Os Ismentioning

confidence: 99%

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Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Yang

Zhou

et al. 2018

American J Rep Immunol

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Melatonin is a neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of mammals. Melatonin acts as a broad-spectrum antioxidant, powerful free radical scavenger, anti-inflammatory agent, anticarcinogenic factor, sleep inducer and regulator of the circadian rhythm, and potential immunoregulator. Melatonin and reproductive system are interrelated under both physiological and pathological conditions. Oxidative stress, inflammation, and immune dysregulation are associated with the pathogenesis of the female reproductive system which causes endometriosis (EMS), recurrent spontaneous abortion (RSA), and polycystic ovary syndrome (PCOS). Accumulating studies have indicated that melatonin plays pleiotropic and essential roles in these obstetrical and gynecological disorders and would be a candidate therapeutic drug to regulate inflammation and immune function and protect special cells or organs. Here, we systematically review the pleiotropic roles of melatonin in EMS, RSA, and PCOS to explore its pathological implications and treatment potential.

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Section: Mel Atonin and Endome Tri Os Ismentioning

confidence: 96%

Section: Mel Atonin and Endome Tri Os Ismentioning

confidence: 99%

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Yang

Zhou

et al. 2018

American J Rep Immunol

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“…This melatonin-induced decrease in endometriotic lesions is correlated with the downregulation of COX-2 levels [183]. Activities of SOD and TIMP-2 are higher after melatonin treatment while VEGF and MMP-9 levels are reduced [184]. Melatonin can lead in the regression of apoptosis through the caspase-3 pathway [185].…”

Section: Curcumin and Melatoninmentioning

confidence: 97%

Curcumin and Endometriosis

Vallée

Lecarpentier²

2020

IJMS

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Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

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“…в исследовании n. Yesildaglar et al было выявлено, что мелатонин эффективен при лечении эндометриоза, индуцированного у sciD-мышей (с тяжелым комбинированным иммунодефицитом) [13]. Мелатонин также способствовал регрессу эндометриоидных имплантатов у крыс путем снижения уровня VegF (эндотелиального фактора роста) -сигнального белка, вырабатываемого клетками для стимуляции ангиогенеза, и подавления выработки противовоспалительных цитокинов [14].…”

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Genital endometriosis and melatonin: a role in the pathogenesis and its possible use in the treatment of the disease

et al. 2019

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Hypothesis/aims of study. Melatonin is found in almost all living organisms, the range of its effects being quite diverse. Effects of this hormone in the human body are realized via two ways, through specific receptors and non-receptor pathways. Melatonin may act through both membrane and nuclear receptors. In the present work, the expression of MTR1 and MTR2 melatonin receptors was studied in the eutopic endometrium and endometrioid heterotopies, and the level of melatonin metabolite, 6-sulfatoxymelatonin, in daily urine in patients with genital endometriosis (GE) was analyzed. Study design, materials and methods. The experimental group included 67 patients of reproductive age with a verified diagnosis of GE, and the control group consisted of 18 individuals with an ovulatory menstrual cycle without gynecological pathology. The 6-sulfatoxymelatonin level in daily urine was determined by enzyme immunoassay. The study of MTR1 and MTR2 melatonin receptor expression in the endometrium and endometrioid heterotopies was performed in 24 patients with GE and in 10 women of reproductive age who were examined for infertility who did not have gynecological pathology based on diagnostic laparoscopy. To study the expression of melatonin receptors, the endometrium and endometrial heterotopy sampling was carried out from day 18 to day 22 of the menstrual cycle. Morphological assessment included histological and immunofluorescence studies using confocal laser scanning microscopy. Results. In patients with GE, there was found a tendency to a decrease in 6-sulfatoxymelatonin excretion in daily urine compared to the control group. It was also found that the total relative expression area of melatonin receptors in the endometrium of women with GE was significantly lower compared to the endometrium of patients from the control group. Significant differences between the average brightness and optical density were not found. In addition, it was revealed that the relative expression areas of MTR1 and MTR2 melatonin receptors in the eutopic endometrium and in endometrioid heterotopies did not differ significantly. A negative correlation was stated between the relative expression area of melatonin receptors and GE prevalence. Particular attention is paid to the role of melatonin in the development of GE and to the possibilities of working out new treatment regimens with its use. Conclusion. The data obtained confirm the undoubted role of melatonin in the pathogenesis of GE, however, the development of new treatment regimens with its use requires further study.

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Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases

Abstract: Melatonin induces the regression of endometriotic implants in rats by modulating implant levels of SOD, MDA, VEGF, MMP-9 and TIMP-2.

Cited by 31 publications

References 42 publications

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Curcumin and Endometriosis

Genital endometriosis and melatonin: a role in the pathogenesis and its possible use in the treatment of the disease

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