Melatonin/Cortisol Ratio in Depression

Wetterberg, Lennart; Beck-Friis, Johan; Apéria, B.; Petterson, U.

doi:10.1016/s0140-6736(79)92837-x

Cited by 133 publications

(34 citation statements)

References 2 publications

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“…In deed, the ratio between the lowest cortisol level and the melatonin peak at night-time was significantly greater in old than in young subjects. These findings are reminescent of the 'low melatonin syndrome' described in pa tients with affective disorders [39], However, it is impor tant to underline that our old subjects did not display major signs of depression.…”

Section: Discussionsupporting

confidence: 75%

Neuroendocrine Correlates of the Aging Brain in Humans

et al. 1995

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Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the CNS and particularly of the limbic-hypothalamic system occurring in aged people. The circadian rhythms of plasma melatonin, ACTH and cortisol and of oral temperature were studied in 16 clinically healthy women aged 66-90 years and in 14 young controls aged 20-30. In addition, the effect of dexamethasone on the plasma cortisol circadian rhythm and the cortisol response to Synacthen pulse intravenous injection were evaluated. All subjects were studied as inpatients, with the same synchronization to the hospital life schedule. When compared with young controls, elderly subjects exhibited a reduction of the mean level and of the amplitude of the circadian rhythm of oral temperature, an increase of the mean level of ACTH and cortisol rhythms and a selective impairment of melatonin nocturnal secretion. Furthermore, elderly subjects showed a reduced sensitivity to the dexamethasone suppression test, by comparison to young controls. These changes were age-related and they may depend either on CNS modification or on alterations of the hormonal metabolic clearance.

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Section: Discussionsupporting

confidence: 75%

Neuroendocrine Correlates of the Aging Brain in Humans

et al. 1995

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“…The early studies suggested lower MT levels in depression and especially in DST nonsuppressors and melancholia [3][4][5][18][19][20]. Rubin et al [21] (at latitude 34°n orth) studied 40 depressed patients (definite endogenous according to Research Diagnostic Criteria, but only 16 fulfilled DSM-III melancholic criteria and 34 were unipolars) and 40 controls.…”

Section: Discussionmentioning

confidence: 99%

“…MT is also a marker of the circadian rhythm, and in depression, a decrease in its nocturnal serum or urine levels or a phase shift in its peak [3,4] has been reported, but not by all authors [5,6]. Other authors relate lower MT activity to an abnormal dexamethasone suppression test (DST) [7] or melancholic features [6,8].…”

Section: Introductionmentioning

confidence: 99%

Morning and Evening Plasma Melatonin and Dexamethasone Suppression Test in Patients with Nonseasonal Major Depressive Disorder from Northern Greece (Latitude 40–41.5°)

et al. 2001

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Introduction: The present study aimed to search for correlations between melatonin (MT) levels and the dexamethasone suppression test (DST) and clinical variables. Methods: Fifty depressed patients aged 21–60 years took part in the study. The Schedules for Clinical Assessment in Neuropsychiatry, version 2.0, and the International Personality Disorders Examination were used for diagnosis. Psychometric assessment included the Hamilton Depression Rating Scale, the Hamilton Anxiety Scale, the General Assessment of Funtioning Scale, the Newcastle scales and the Diagnostic Melancholia Scale. The DST and 9.00 and 23.00 h MT values were assessed. Statistical analysis included Student’s t test, Pearson product moment correlation coefficient and forward stepwise multiple linear regression analysis. Results: Melancholic patients had lower 23.00 h MT values in comparison to the rest of the patients and the atypical and ‘undifferentiated’ patients. Conclusion: The current study shows that low MT values were closely related to melancholic depression. Distinct quality of mood, psychomotor agitation or retardation and anorexia or weight loss seemed to be responsible for this relationship.

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“…The basis for the interest in melaton in in affective disorders was a report by Wetterberg et al (5) in which higher cortisol levels were seen during depre ssion than during recovery and the peak level of melatonin occurred earlier dur ing the disease stat e.…”

Section: Neuroendocrine Changes In Affective Disordersmentioning

confidence: 99%

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Wetterberg¹

1990

Scand J Work Environ Health

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Melatonin/Cortisol Ratio in Depression

Cited by 133 publications

References 2 publications

Neuroendocrine Correlates of the Aging Brain in Humans

Neuroendocrine Correlates of the Aging Brain in Humans

Morning and Evening Plasma Melatonin and Dexamethasone Suppression Test in Patients with Nonseasonal Major Depressive Disorder from Northern Greece (Latitude 40–41.5°)

Lighting. Nonvisual effects.

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