2013
DOI: 10.1016/j.bpj.2012.11.1022
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Melatonin Counteracts Cholesterol's Effects on Lipid Membrane Structure

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Cited by 4 publications
(2 citation statements)
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“…has been already observed by numerous techniques, so our results are in good agreement with previously reported data. [ 56,95–97 ] However, despite the commonly accepted procedure to estimate ordering/disordering in the DPPC membrane using Raman spectroscopy, [ 16,19,21,91,94 ] where Raman modes intensity I 1063 /I 1096 ratio has been suggested for disordering and I 1128 /I 1096 for ordering, here we report that only I 1128 /I 1096 adequately represents the concentration effect of chol. and mel.…”
Section: Resultscontrasting
confidence: 57%
“…has been already observed by numerous techniques, so our results are in good agreement with previously reported data. [ 56,95–97 ] However, despite the commonly accepted procedure to estimate ordering/disordering in the DPPC membrane using Raman spectroscopy, [ 16,19,21,91,94 ] where Raman modes intensity I 1063 /I 1096 ratio has been suggested for disordering and I 1128 /I 1096 for ordering, here we report that only I 1128 /I 1096 adequately represents the concentration effect of chol. and mel.…”
Section: Resultscontrasting
confidence: 57%
“…Previous studies on melatonin's effect on model membranes have revealed that it is able to fluidize the membrane while enhancing the lipid dynamics and increasing the area per lipid [20,22,23]. It counteracts the ordering effect of cholesterol [24,25] and acts similarly to its biosynthetic precursors tryptophan, serotonin and N-Acetylserotonin (NAS) [26]. With nuclear magnetic resonance (NMR), melatonin was also shown to influence the phase separation in the DPPC/POPC/cholesterol membrane model [27].…”
Section: Introductionmentioning
confidence: 99%