Melatonin deficiencies in women

Rohr, Uwe D.; Herold, J.

doi:10.1016/s0378-5122(02)00017-8

Cited by 48 publications

(42 citation statements)

References 83 publications

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“…This theory, known as the melatonin hypothesis, attributes increased cancer risk to decreased melatonin excretion due to the presence of light at night. Melatonin levels have a typical circadian rhythmicity, with the peak of circulating melatonin levels occurring in the middle of the night around 4am, a time at which natural light is rarely present and most humans are asleep (Healy and Waterhouse, 1995;Rohr and Herold, 2002;Stow and Gumz, 2011). However, with the advent of artificial light, sleep/wake and work cycles have become more malleable, and light exposure can easily occur during times that are atypical evolutionarily.…”

Section: Circadian Disruption In Humans and The Melatonin Hypothesismentioning

confidence: 99%

The contribution of circadian rhythms to cancer formation and mortality

Birky¹,

Bray²

2014

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Cellular circadian clocks represent a coordinated system of gene expression stimulated by both environmental and physiological cues that induces and maintains the rhythmicity of many metabolic processes. Circadian clocks confer the important benefit of anticipation of rhythmic environmental variation which serves to improve the health and survival of the organism. When disruption of these circadian patterns of gene expression occurs due to alterations in the physical (light/dark) and behavioral (feeding/sleeping) environments and/or due to genetic variation in the DNA sequence of clock component and clock regulated genes, negative health consequences can arise. One such consequence appears to be increased risk for cancer development. Circadian disruption has been associated with higher rates of tumorigenesis, faster tumor growth, and increased cancer severity in humans and animal models. Tumor formation is also associated with circadian disruption within the affected cells, and metabolic processes of the cancer host tend to lose their rhythmicity as the cancer becomes more severe. In addition, response to cancer treatment has been shown to have a time-dependent component in certain individuals. Knowledge of the type of circadian disruptions that induce or result from cancer can allow for temporally augmented treatments of cancer, ultimately making cancer treatments more effective and less harmful.

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Section: Circadian Disruption In Humans and The Melatonin Hypothesismentioning

confidence: 99%

The contribution of circadian rhythms to cancer formation and mortality

Birky¹,

Bray²

2014

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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“…Gece saatlerinde serotonin miktarının azalması melatonin sentezinin artmasından yani serotoninin melatonine dönüştürülmesinden kaynaklanmaktadır. [8,11,[17][18][19][20][21] Hayvan deneylerinde NAT enzimi aktivitesinin ve dolayısıyla melatoninin kan düzeyinin karanlıkta zirve yaptığı gösterilmiştir. Bu periyod, pineal bezde norepinefrinin dönüşümünün ve bezi innerve eden sempatik sinir liflerinden kaynaklanan spontan aktivitenin tepe yaptığı saatlere rastlamaktadır.…”

Section: Melatonin Metabolizmasıunclassified

“…Ayrıca uykuya başlama hızının ve uyku kalitesinin artacağı da bildirilmektedir. [18,19,32,33] Dikkat eksikliği/hiperaktivite ve uyku başlangıcında bozukluğu (sleep-onset insomnia) olan çocuk hastalar için melatonin tedavisi öne-rilmektedir. [34] Ancak bazı araştırmalarda uyku problemi yaşayan erişkin kişilerdeki melatonin düzeyinin uyku problemi olmayan kişilerden düşük olmadığı bulunmuştur.…”

Section: Melatonin Uyku Ve Uykusuzlukunclassified

An Overview On Melatonin Hormone

Özçeli̇k¹,

Erdem²,

Bolu³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETMelatonin hormonu, son yıllarda tüm dünyada gittikçe artan bir ilgiyle araştı-rılmaktadır. Ana görevi vücudun biyolojik saatini koruyup ritmini ayarlamak olan melatonin, vücudun birçok biyolojik ve fizyolojik süreçlerinde yer alır. Hücrelerin yenilenmesi, bağışıklık siteminin güçlenmesi, uyku ritminin ve vücut ısısının düzenlenmesi diğer önemli görevleri arasındadır. Lipofilik özel-liği nedeniyle bilinen en güçlü antioksidandır. Bu özelliği sayesinde tüm vücut alanlarına ulaşabilmekte ve kan-beyin bariyerini geçebilmektedir. Uyku problemi olan kişilerde melatoninin düşük düzeyde bulunması, ilaç olarak kullanımını akla getirmektedir. Yapılan uygulamaların ardından melatoninin uyku total süresini değiştirmeden uyku kalitesini artırdığı belirlenmiştir. Ancak yaygın araştırılmasına rağmen melatoninin işlevleri halen tamamıyla bilinmemektedir. Bu nedenle melatonin ile ilgili mevcut bilgilerin gözden geçirilmesi, bu alanda araştırma yapanlara rehberlik edecektir. Anahtar Sözcükler: Melatonin, uyku, biyolojik saat, antioksidan. ABSTRACTIn recent years, there is a growing interest in melatonin all over the world. The main task of protecting the body's biological clock, which set the rhythm of melatonin, involves many biological and physiological processes of the body. Cell renewal, strengthening of the immune system and body temperature regulation are other tasks of melatonin. Melatonin, with its lipophilic property, is the most powerful antioxidant as it can reach all body areas and can easily pass the blood-brain barrier. The fact that individuals with low levels of melatonin have sleep problems lead to the consideration of melatonin as a therapeutic medicine in this field. The detailed researches have shown that melatonin can improve sleep quality without changing the total duration of sleep. Nevertheless, despite high number of researches done, the functions ©2013, Psikiyatride Güncel Yaklaşımlar eISSN:1309-0674 pISSN:1309-0658

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“…Because of the good safety profile of melatonin, without either hang-over or tolerance development, the authors recommended considering using it as treatment, even more in cases when a deficiency may occur, such as in people suffering from FM [74].…”

Section: Fibromyalgia and Nutritional Statusmentioning

confidence: 99%

Fibromyalgia and nutrition, what do we know?

Arranz

Canela²,

Rafecas

2010

Rheumatol Int

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Objective: Many people suffer from fibromyalgia (FM) without an effective treatment. They do not have a good quality of life and cannot maintain normal daily activity. Among the different hypotheses for its ethiopathophysiology, oxidative stress is one of the possibilities. Non-scientific information addressed to patients regarding the benefits of nutrition is widely available, and they are used to trying non-evidenced strategies. The aim of this paper is to find out what we know right now from scientific studies regarding fibromyalgia disease and nutritional status, diets and food supplements. Design: A systematic search has been performed on Medline with a wide range of terms about these nutritional issues. Setting: the search has been made during 2009, for articles published between 1998 and 2008. Subjects: people suffering from FM. Results: Vegetarian diets could have some beneficial effects probably due to the increase in antioxidant intake. There is a high prevalence of obesity and overweight in patients, and weight control seems to be an effective tool to improve the symptoms. Some nutritional deficiencies have been described, it is not clear whether they are directly related to this disease or not. About the usefulness of some food supplements we found very little data, and it seems that more studies are needed to prove which ones could be of help. Conclusions: Dietary advice is necessary to these patients to improve their diets and maintain normal weight. It would be interesting to investigate more in the field of nutrition and FM to reveal any possible relationships.

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Melatonin deficiencies in women

Cited by 48 publications

References 83 publications

The contribution of circadian rhythms to cancer formation and mortality

The contribution of circadian rhythms to cancer formation and mortality

An Overview On Melatonin Hormone

Fibromyalgia and nutrition, what do we know?

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