Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose–response meta-analysis of controlled clinical trials

Zarezadeh, Meysam; Barzegari, Maliheh; Aghapour, Baharak; Adeli, Shaghayegh; Khademi, Fateme; Musazadeh, Vali; Jamilian, Parsa; Jamilian, Parmida; Fakhr, Laleh; Chehregosha, Fatemeh; Ghoreishi, Zohreh; Ostadrahimi, Alireza

doi:10.1016/j.clnesp.2022.01.038

Cited by 27 publications

(12 citation statements)

References 47 publications

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“…The rise in melatonin levels could represent a physiological attempt to actively respond to oxidative stress, secondary to a serious and critical disease process. Furthermore, this same physiological response seems to be compromised with advancing age, showing reduced melatonin concentrations in the adult patient in critical condition [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

et al. 2023

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Surgery is frequently associated with excessive oxidative stress. Melatonin acts as an antioxidant and transient melatonin deficiency has been described in neonatal surgical patients. This randomized, blinded, prospective pilot study tested the hypothesis that oral melatonin supplementation in newborn infants undergoing surgery is effective in reducing perioperative oxidative stress. A total of twenty-three newborn infants requiring surgery were enrolled: 10 received a single dose of oral melatonin 0.5 mg/kg in the morning, before surgery (MEL group), and 13 newborns served as the control group (untreated group). Plasma concentrations of melatonin, Non-Protein-Bound Iron (NPBI), Advanced Oxidation Protein Products (AOPP), and F2-Isoprostanes (F2-IsoPs) were measured. Both in the pre- and postoperative period, melatonin concentrations were significantly higher in the MEL group than in the untreated group (preoperative: 1265.50 ± 717.03 vs. 23.23 ± 17.71 pg/mL, p < 0.0001; postoperative: 1465.20 ± 538.38 vs. 56.47 ± 37.18 pg/mL, p < 0.0001). Melatonin significantly increased from the pre- to postoperative period in the untreated group (23.23 ± 17.71 vs. 56.47 ± 37.18 pg/mL; pg/mL p = 0.006). In the MEL group, the mean blood concentrations of NPBI, F2-IsoPs, and AOPP significantly decreased from the pre- to the postoperative period (4.69 ± 3.85 vs. 1.65 ± 1.18 micromol/dL, p = 0.049; 128.40 ± 92.30 vs. 50.25 ± 47.47 pg/mL, p = 0.037 and 65.18 ± 15.50 vs. 43.98 ± 17.92 micromol/dL, p = 0.022, respectively). Melatonin concentration increases physiologically from the pre- to the postoperative period, suggesting a defensive physiologic response to counteract oxidative stress. The administration of exogenous melatonin in newborn infants undergoing surgery reduces lipid and protein peroxidation in the postoperative period, showing a potential role in protecting babies from the deleterious consequences of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

“…Because of the occurrence of oxidative stress in patients undergoing surgery, the putative application of melatonin as a therapy has emerged, based on its cytoprotective properties [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

et al. 2023

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“…Melatonin contains an electron-rich aromatic ring that enables melatonin to act as an electron donor and subsequently reduce the concentration of free radicals during periods of oxidative stress [ 76 ]. Oxidative stress develops when oxygen byproducts from the electron transport chain contain unstable electrons that then react to form ROS beyond the levels of antioxidants, thereby increasing the concentrations of free radicals [ 149 ]. At supra-physiologic levels, as seen with supplementation, melatonin can exert both receptor-mediated and intracellular effects, capable of diffusing to the microenvironment of cellular injury to perform its oxidative scavenging function [ 76 , 111 , 150 , 151 , 152 , 153 , 154 , 155 ].…”

Section: Discussionmentioning

confidence: 99%

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

et al. 2023

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Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity in the United States and is associated with numerous chronic sequelae long after the point of injury. One of the most common long-term complaints in patients with TBI is sleep dysfunction. It is reported that alterations in melatonin follow TBI and may be linked with various sleep and circadian disorders directly (via cellular signaling) or indirectly (via free radicals and inflammatory signaling). Work over the past two decades has contributed to our understanding of the role of melatonin as a sleep regulator and neuroprotective anti-inflammatory agent. Although there is increasing interest in the treatment of insomnia following TBI, a lack of standardization and rigor in melatonin research has left behind a trail of non-generalizable data and ambiguous treatment recommendations. This narrative review describes the underlying biochemical properties of melatonin as they are relevant to TBI. We also discuss potential benefits and a path forward regarding the therapeutic management of TBI with melatonin treatment, including its role as a neuroprotectant, a somnogen, and a modulator of the circadian rhythm.

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“…In situations of low-grade inflammation, such as obesity, the chronicity of in-flammation can lead to comorbidities, such as cardiovascular disease, insulin resistance, anemia, hyperlipidemia, metabolic syndrome, T2DM and cancer ( 18 – 20 ). Among the promising therapeutic strategies, it was recently demonstrated that melatonin, as the main product of the pineal gland, is considered a broad-spectrum antioxidant, can be applied in pathological conditions such as T2DM, mainly for its regulatory effects on the expression of the glucose transporter gene type 4 (GLUT4), glucose homeostasis and insulin sensitivity ( 21 – 23 ).…”

Section: Introductionmentioning

confidence: 99%

12-week melatonin administration had no effect on diabetes risk markers and fat intake in overweight women night workers

de Sousa,

Nogueira,

Cipolla-Neto

et al. 2024

Front. Nutr.

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IntroductionInteractions between circadian clocks and key mediators of chronic low-grade inflammation associated with fat consumption may be important in maintaining metabolic homeostasis and may pose a risk for the development of obesity-associated comorbidities, especially type 2 diabetes (T2DM).ObjectiveThe aims of the present study were to evaluate the effects of melatonin administration on diabetes risk markers according to dietary lipid profile (pro-inflammatory versus anti-inflammatory) in excessive weight night workers, and to determine the effect of administration on fat consumption profile.MethodsA randomized, controlled, double-blind, crossover clinical trial involving 27 nursing professionals working permanent night shifts under a 12×36-hour system. The melatonin group (12 weeks) used synthetic melatonin (3 mg) only on days off and between shifts, while the placebo group (12 weeks) was instructed to take a placebo, also on days off and between shifts. For inflammatory characteristics, participants were divided into pro-inflammatory (saturated fats, trans fats and cholesterol) and anti-inflammatory (monounsaturated, polyunsaturated fats and EPA + DHA) groups according to fatty acid determinations. At baseline and at the end of each phase, blood glucose, insulin, glycosylated hemoglobin plasma concentrations were collected, and HOMA-IR was calculated.ConclusionMelatonin administration for 12 weeks had no effect on T2DM risk markers according to dietary lipid profile (pro-inflammatory or anti-inflammatory potential) in excessive weight night workers. Among the limitations of the study include the fact that the low dose may have influenced the results expected in the hypothesis, and individual adaptations to night work were not evaluated. The insights discussed are important for future research investigating the influence of melatonin and fats considered anti- or pro-inflammatory on glucose and insulin homeostasis related to night work.

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Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose–response meta-analysis of controlled clinical trials

Cited by 27 publications

References 47 publications

Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

12-week melatonin administration had no effect on diabetes risk markers and fat intake in overweight women night workers

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