Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis

Alonso‐González, Carolina; González, Alicia; Martínez‐Campa, Carlos; Menéndez-Menéndez, Javier; Gómez-Arozamena, José; García-Vidal, Angela; Cos, Samuel

doi:10.1016/j.canlet.2015.10.015

Cited by 54 publications

(67 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, the animals were treated with melatonin in advance of the radiation therapy. The second study yielded similar results and suggested that the enhancing action of melatonin in radiation-treated cancers related to its modulation of p53 [223]. …”

Section: Melatonin and Cancer Progressionmentioning

confidence: 83%

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Reíter

Rosales-Corral

Tan

et al. 2017

IJMS

376

368

View full text Add to dashboard Cite

There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, however, is the large number of processes by which melatonin reportedly restrains cancer development and growth. These diverse actions suggest that what is being observed are merely epiphenomena of an underlying more fundamental action of melatonin that remains to be disclosed. Some of the arresting actions of melatonin on cancer are clearly membrane receptor-mediated while others are membrane receptor-independent and involve direct intracellular actions of this ubiquitously-distributed molecule. While the emphasis of melatonin/cancer research has been on the role of the indoleamine in restraining breast cancer, this is changing quickly with many cancer types having been shown to be susceptible to inhibition by melatonin. There are several facets of this research which could have immediate applications at the clinical level. Many studies have shown that melatonin’s co-administration improves the sensitivity of cancers to inhibition by conventional drugs. Even more important are the findings that melatonin renders cancers previously totally resistant to treatment sensitive to these same therapies. Melatonin also inhibits molecular processes associated with metastasis by limiting the entrance of cancer cells into the vascular system and preventing them from establishing secondary growths at distant sites. This is of particular importance since cancer metastasis often significantly contributes to death of the patient. Another area that deserves additional consideration is related to the capacity of melatonin in reducing the toxic consequences of anti-cancer drugs while increasing their efficacy. Although this information has been available for more than a decade, it has not been adequately exploited at the clinical level. Even if the only beneficial actions of melatonin in cancer patients are its ability to attenuate acute and long-term drug toxicity, melatonin should be used to improve the physical wellbeing of the patients. The experimental findings, however, suggest that the advantages of using melatonin as a co-treatment with conventional cancer therapies would far exceed improvements in the wellbeing of the patients.

show abstract

Section: Melatonin and Cancer Progressionmentioning

confidence: 83%

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Reíter

Rosales-Corral

Tan

et al. 2017

IJMS

376

368

View full text Add to dashboard Cite

show abstract

“…Pretreatment with melatonin on MCF-7 breast cancer cells 1 week before radiation could sensitize cancer cells to the ionizing effects of radiation, through inhibiting proliferation, promoting cell cycle arrest and inhibiting proteins involved in double-strand DNA break repair [79]. Another study suggested the enhancing effect of melatonin on the radiosensitivity of human breast cancer cells might be associated with the increase of p53 expression [80]. …”

Section: Experimental Studiesmentioning

confidence: 99%

Melatonin for the prevention and treatment of cancer

et al. 2017

View full text Add to dashboard Cite

The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experimental studies have documented that melatonin could exert growth inhibition on some human tumor cells in vitro and in animal models. The underlying mechanisms include antioxidant activity, modulation of melatonin receptors MT1 and MT2, stimulation of apoptosis, regulation of pro-survival signaling and tumor metabolism, inhibition on angiogenesis, metastasis, and induction of epigenetic alteration. Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the side effects of chemotherapies or radiation. Melatonin could be an excellent candidate for the prevention and treatment of several cancers, such as breast cancer, prostate cancer, gastric cancer and colorectal cancer. This review summarized the anticancer efficacy of melatonin, based on the results of epidemiological,experimental and clinical studies, and special attention was paid to the mechanisms of action.

show abstract

“…Alonso-Gonzalez et al pointed out that the pretreatment of 1 nM melatonin before radiation could elevate the sensitivity of human breast cancer cells to radiotherapy by reducing the active estrogens levels in cancer cells through the increased p53 expression [243]. It was also found that melatonin-based creams could significantly lower the occurrence of acute radiation dermatitis in a double-blind randomized trial [244].…”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

View full text Add to dashboard Cite

Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

show abstract

Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis

Cited by 54 publications

References 40 publications

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Melatonin for the prevention and treatment of cancer

Dietary Sources and Bioactivities of Melatonin

Contact Info

Product

Resources

About