2010
DOI: 10.1111/j.1600-079x.2010.00779.x
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Melatonin enhances antioxidant action of α-tocopherol and ascorbate against NADPH- and iron-dependent lipid peroxidation in human placental mitochondria

Abstract: Human placental mitochondria might be a significant source of NADPH- and iron-dependent production of reactive oxygen species (ROS). Preeclampsia is believed to be a consequence of overproduction of ROS in human placenta. The experimental results presented here show that melatonin inhibits NADPH- and iron-dependent lipid peroxidation of human placental mitochondria in a concentration-dependent manner. At 1.5 mm concentration, melatonin suppressed this process nearly completely. Melatonin does not influence sig… Show more

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Cited by 46 publications
(41 citation statements)
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“…This is consistent with the opinion that melatonin influences the activity and expression of the antioxidative enzymes, i.e. glutathione peroxidase, SOD, and CAT (13,(23)(24)(25), as well as antioxidant vitamins (26).…”
Section: Discussionsupporting
confidence: 92%
“…This is consistent with the opinion that melatonin influences the activity and expression of the antioxidative enzymes, i.e. glutathione peroxidase, SOD, and CAT (13,(23)(24)(25), as well as antioxidant vitamins (26).…”
Section: Discussionsupporting
confidence: 92%
“…The antioxidant properties of Mel and its ability to scavenge several radical species as part of its bioactivity have been described in the literature (Allegra et al, 2003;Reiter et al, 2003;Estevão et al, 2011), both by direct and indirect mechanisms (Barrenetxe et al, 2004;Milczarek et al, 2010). Indeed, it scavenges ROS and RNS, and metabolites formed afterwards are also radical scavengers in their turn (Tan et al, 2007).…”
Section: Introductionmentioning
confidence: 91%
“…In addition, melatonin reportedly scavenges singlet oxygen ( 1 O 2 ), superoxide anion radical (O 2 ÅÀ ), hydrogen peroxide (H 2 O 2 ), nitric oxide (NO Å ) and hypochlorous acid (HClO). Several metabolites formed when melatonin interacts with radicals are also highly effective scavengers (Milczarek, Hallmann, Sokolowska, Kaletha, & Klimek, 2010). These products include cyclic 3-hydroxymelatonin, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK).…”
Section: Introductionmentioning
confidence: 99%