Melatonin: Exceeding Expectations

Reíter, Russel J.; Tan, Dun Xian; Galano, Annia

doi:10.1152/physiol.00011.2014

Cited by 470 publications

(494 citation statements)

References 66 publications

Supporting

Mentioning

466

Contrasting

Unclassified

Order By: Relevance

“…Melatonin (N-acetyl-5-methoxytryptamine), an indole compound synthesized by the pineal gland and many other tissues, is a critical inhibitor of tumors [7][8][9][10][11][12][13][14]. This molecule executes its anticancer effects in various types of cancer due to its pro-apoptotic, anti-proliferative, anti-cell differentiation and anti-angiogenic actions [15,16].…”

Section: Introductionmentioning

confidence: 99%

The impact of melatonin and carbon ion irradiation on cancer stem cells

Liu¹,

Reíter²

2017

Nucl Med Biomed Imaging

View full text Add to dashboard Cite

Aim: Cancer stem cells (CSCs) exhibited an excessive migratory and invasive potential. Melatonin may inhibit multiple crucial signals associated with tumor stem cell self-renewal, viability, invasiveness, tumor growth, and therapy resistance. Carbon ion irradiation may be a promising therapeutic modality in both non-stem-like and stem-like tumor cells in contrast to photon irradiation. A comprehensive understanding of the mechanisms and molecular pathways associated with invasive properties of CSCs is essential in developing novel treatment options for cancer therapy that target CSCs. Materials and methods:A systematic review of the existing literature was conducted using the following search terms: 'melatonin', 'X-ray irradiation', 'charged particle irradiation', 'carbon ion irradiation', 'cancer stem cells', 'tumor-initiating cells' and 'cancer stem-like cells'. The search used PubMed and spanned the period from January 2000 to December 2016. Conclusion:Cancer stem cells possess the capacity of self-renewal and pluripotency, generating all cells within a tumor, and are responsible for tumor growth, therapy resistance and metastasis. Melatonin attenuated AKT activation, EZH2 S21 phosphorylation, EZH2-STAT3 interactions and altered histone modifications to reduce tumor initiation and propagation of brain tumor stem cells (BTSC). Melatonin increases the efficacy of chemotherapeutic agents, targeting both the tumor bulk and BTSCs through the regulation of the expression and function of the ABCG2/BCRP transporter by inducing the methylation of its promoter. Melatonin treatment induced cell death with ultrastructural characteristics of autophagy. Breast cancer stem cells (BCSCs) are responsive to melatonin treatment by way of reducing the viability and the invasiveness of breast cancer mammospheres as well as regulating the expression of OCT4, N-cadherin and vimentin proteins associated with epithelial mesenchymal transition in BCSCs. Carbon irradiation is effective in brain tumor stem cell (BTSC) elimination with relative biologic effectiveness (RBE) in the range of 1.87-3.44. Carbon ion irradiation may be a promising therapeutic modality because it reduces migration and invasion processes in both head and neck squamous cell carcinoma and cancer stem cells in contrast to photon irradiation. Low LET X-ray irradiation may essentially eradicate the non-stem-like tumor cells, consequently the radioresistant cancer stem-like cell population is obviously enriched. In contrast, carbon ion irradiation may eradicate both non-stemlike and stem-like tumor cells at the same time. Carbon ion irradiation is a promising tool to eradicate putative colon cancer stem-like cells. Further investigation to elucidate the mechanisms and molecular pathways involved in cancer stem cells particularly associated with melatonin and carbon ion irradiation certainly is warranted.

show abstract

Section: Introductionmentioning

confidence: 99%

The impact of melatonin and carbon ion irradiation on cancer stem cells

Liu¹,

Reíter²

2017

Nucl Med Biomed Imaging

View full text Add to dashboard Cite

show abstract

“…It is synthesized when pineal gland is stimulated by darkness and inhibited by light [3]. Melatonin has several actions including detoxification of free radicals, protecting various cells and tissues from the damaging effects of oxidative stress in medical disorders such as: ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity [4]. Since melatonin has the potent anti-cancer activity, the International Agency for Research on Cancer (IARC) has classified night work shifts that suppress melatonin secretion (circadian interruption) as a possible carcinogenic factor (Group 2A) [5] [6] [7] [8].…”

mentioning

confidence: 99%

Light Pollution Associated with Delayed Sleep Time: A Major Hygienic Problem in Saudi Arabia

Ahmed¹,

Alogla²,

Ismael³

et al. 2017

JBBS

View full text Add to dashboard Cite

Background: It was well established that exposure to nighttime light was responsible of a diverse negative health effect. Therefore, the aim of this study was to assess the epidemiologic exposure to artificial light at night time and negative health consequences that associated with prolonged nighttime lighting exposure. Methodology: This is a cross-sectional survey, involving a total of 266 Saudi residents living in the city of Hail, Northern KSA. Essential information regarding exposure to light at night time was obtained. Results: The overall incidence of nighttime light exposure in the present study was 65.8% for general population, was 61.5% males and was 38.5% for females. About 75.6% persons used to sleep for <6 hours and 36.8% individuals used to sleep on light exposure. Conclusion: Prolonged exposure to the light at nighttime is prevalent in Saudi Arabia. This exposure usually results from late sleep in the nighttime and the late awake in the daytime.

show abstract

“…Melatonin has a number of significant effects, being an antioxidant, anti-inflammatory, antinociceptive and immune regulator, as well as optimizing mitochondrial functioning and inducing endogenous antioxidants (33). Such effects allow melatonin to have clinical efficacy across a wide diversity of medical conditions, including neurodegenerative and psychiatric disorders (34) as well as in the management of cancers (35).…”

Section: Melatonergic Pathwaysmentioning

confidence: 99%

Breastfeeding and the gut-brain axis: is there a role for melatonin?

Anderson¹,

Vaillancourt²,

Maes

et al. 2017

Biomolecular Concepts

Self Cite

View full text Add to dashboard Cite

The benefits of breastfeeding over formula feed are widely appreciated. However, for many mothers breastfeeding is not possible, highlighting the need for a significant improvement in the contents of formula feed. In this article, the overlooked role of melatonin and the melatonergic pathways in breast milk and in the regulation of wider breast milk components are reviewed. There is a growing appreciation that the benefits of breastfeeding are mediated by its effects in the infant gut, with consequences for the development of the gut-brain axis and the immune system. The melatonergic pathways are intimately associated with highly researched processes in the gut, gut microbiome and gut-brain axis. As the melatonergic pathways are dependent on the levels of serotonin availability as a necessary precursor, decreased melatonin is linked to depression and depression-associated disorders. The association of breastfeeding and the gut-brain axis with a host of medical conditions may be mediated by their regulation of processes that modulate depression susceptibility. The biological underpinnings of depression include increased levels of pro-inflammatory cytokines, oxidative stress, kynurenine pathway activity and dysregulation of the hypothalamic-pituitary adrenal axis, all of which can decrease melatonergic pathway activity. The inclusion of the melatonergic pathways in the biological interactions of breast milk and gut development has significant theoretical and treatment implications, as well as being important to the prevention of a host of infant-, child-and adult-onset medical conditions.

show abstract

Melatonin: Exceeding Expectations

Cited by 470 publications

References 66 publications

The impact of melatonin and carbon ion irradiation on cancer stem cells

The impact of melatonin and carbon ion irradiation on cancer stem cells

Light Pollution Associated with Delayed Sleep Time: A Major Hygienic Problem in Saudi Arabia

Breastfeeding and the gut-brain axis: is there a role for melatonin?

Contact Info

Product

Resources

About