Melatonin Fails to Modulate Immune Parameters Influenced by Calorie Restriction in Aging Fischer 344 Rats

Pahlavani, Mohammad A.; Vargas, Daniel A.; Evans, Ted R.; Shu, Jian; Nelson, James F.

doi:10.1177/153537020222700308

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…1986; Pahlavani 2000; Ha et al . 2001; Pahlavani et al 2002), including the proliferative capacity and functioning of T‐ and B‐cells (Nakamura et al . 1990; Kubo et al .…”

Section: Discussionmentioning

confidence: 99%

Photoperiod and food restriction differentially affect reproductive and immune responses in Siberian hamsters Phodopus sungorus

Zysling¹,

Garst

Demas

2009

Functional Ecology

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Summary 1.Organisms must contend with seasonal fluctuations in energy availability. To maintain a positive energy balance year-round, a number of adaptations have evolved including seasonal changes in reproduction, energetics and immunity. Photoperiod is the primary environmental signal most animals use to predict seasonal events. Despite the established link between energetics and immune function, little is known regarding how changes in energy availability affect immunity. 2. The goal of the present study was to determine the effects of food restriction on photoperiodic changes in reproduction and immune function in the Siberian hamster ( Phodopus sungorus ). Adult hamsters were housed in long or short days and were food restricted or fed ad libitum . Immune responses were quantified by measuring specific antibody production and bacterial killing capacity. 3. Food restriction decreased body and relative reproductive masses in long-day animals. Antibody responses, but not bacterial killing ability, were enhanced in food restricted short-day animals as compared with ad libitum fed controls. We also found differential effects of body fat on immune responses depending on the immune measure. 4. The effects of food restriction on immune function appear to vary based on the restriction regimen, the response measured, and the physiological state of the organism including energy balance, metabolic rate and reproductive status. 5. In conclusion, these results suggest that a wide range of factors can differentially affect immune function. In addition, these effects may vary based on the specific response examined. Future studies should include a variety of measurements to provide a more integrative and accurate picture of reproductive, energetic, and photoperiodic effects on immune function.

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“…1986; Pahlavani 2000; Ha et al . 2001; Pahlavani et al 2002), including the proliferative capacity and functioning of T‐ and B‐cells (Nakamura et al . 1990; Kubo et al .…”

Section: Discussionmentioning

confidence: 99%

Photoperiod and food restriction differentially affect reproductive and immune responses in Siberian hamsters Phodopus sungorus

Zysling¹,

Garst

Demas

2009

Functional Ecology

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“…Early studies in Fischer 344 rats showed that 40% DR attenuated the age-related decline in pineal function and melatonin secretion [24]. However, the immune response in rats following melatonin supplementation was not improved as it was with DR [25].…”

Section: Melatoninmentioning

confidence: 99%

Dietary Restriction in Aging Nonhuman Primates

Mattison¹,

Roth²,

Lane³

et al. 2006

Interdisciplinary Topics in Gerontology

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Dietary restriction (DR) has been shown to benefit health and longevity in a wide variety of species, although most have maximal life spans of only a few years. In 1987, the National Institute on Aging began the first well-controlled long-term study in a species with a considerably longer life span and a closer physiology to humans. Using rhesus monkeys (Macaca mulatta), an extensive array of physiological measures have been conducted in both males and females to evaluate the effects of DR. Monkeys benefit from DR with a lower body weight, body fat, blood glucose and thus are at lower risk for developing diabetes. Changes in several endocrine measures indicate an altered hormonal axis; however, circadian patterns and timing relative to the onset of DR can obscure the differences. Despite the caloric deficit, female monkeys are not reproductively compromised, and both males and females may benefit immunologically. There remains much to be learned from this model of DR including whether long-term DR will increase life span in a primate species.

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“…Some reports indicate that CR reduces endogenous NK cell activity in the spleen of mice and impairs enhancement of NK cell activity in the lung after intranasal infection of the influenza virus, 21,22) but another study clarified that CR did not affect endogenous NK cell activity and enhanced IL-2-induced NK cell activity in rats. 23) We have observed that the cytolytic activity of NK cells declined in younger mice (11 weeks old) but not in older mice (22 weeks old) even when they were similarly subjected to 40% DR. These results indicate that the influence of DR on NK cells varies depending on age-related changes in immune functions.…”

Section: Discussionmentioning

confidence: 82%

Immune Deviation and Alleviation of Allergic Reactions in Mice Subjected to Dietary Restriction

Yamazaki

Kato-Nagaoka

Suzuki

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Melatonin Fails to Modulate Immune Parameters Influenced by Calorie Restriction in Aging Fischer 344 Rats

Cited by 14 publications

References 36 publications

Photoperiod and food restriction differentially affect reproductive and immune responses in Siberian hamsters Phodopus sungorus

Photoperiod and food restriction differentially affect reproductive and immune responses in Siberian hamsters Phodopus sungorus

Dietary Restriction in Aging Nonhuman Primates

Immune Deviation and Alleviation of Allergic Reactions in Mice Subjected to Dietary Restriction

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