Melatonin for Chronic Sleep Onset Insomnia in Children: A Randomized Placebo-Controlled Trial

Smits, Marcel G.; Nagtegaal, Elsbeth; Heijden, Janine van der; Coenen, A.M.L.; Kerkhof, G.A.

doi:10.2310/7010.2001.6942

Cited by 35 publications

(28 citation statements)

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“…Case series in healthy children (Ivanenko et al 2003) or those with developmental disorders (Miyamoto et al 1999;Niederhofer et al 2003) suggest that melatonin has been effective for sleep disorders, while randomised controlled studies in typically-developing children have also shown benefits, particularly with sleep onset (Smits et al 2001(Smits et al , 2003. However, very few studies have examined its effectiveness for children with developmental disorders.…”

Section: Introductionmentioning

confidence: 95%

Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial

Wright

Sims²,

Smart³

et al. 2010

J Autism Dev Disord

175

168

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Twenty-two children with autism spectrum disorders who had not responded to supported behaviour management strategies for severe dysomnias entered a double blind, randomised, controlled crossover trial involving 3 months of placebo versus 3 months of melatonin to a maximum dose of 10 mg. 17 children completed the study. There were no significant differences between sleep variables at baseline. Melatonin significantly improved sleep latency (by an average of 47 min) and total sleep (by an average of 52 min) compared to placebo, but not number of night wakenings. The side effect profile was low and not significantly different between the two arms.

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Section: Introductionmentioning

confidence: 95%

Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial

Wright

Sims²,

Smart³

et al. 2010

J Autism Dev Disord

175

168

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“…The etiology of ADHD-related chronic sleep-onset insomnia is unknown. In a series of studies on childhood chronic sleep-onset insomnia, we found many ADHD children with characteristics of a delayed endogenous circadian pacemaker, such as a delayed sleep onset, dim light melatonin onset (DLMO), and wake-up time Smits et al, 2001). The endogenous circadian pacemaker is the hypothalamic suprachiasmatic nucleus that endogeneously generates a near 24 h rhythm, and entrains to light-dark input ascending from the retina.…”

Section: Introductionmentioning

confidence: 98%

Idiopathic Chronic Sleep Onset Insomnia in Attention‐Deficit/Hyperactivity Disorder: A Circadian Rhythm Sleep Disorder

Heijden

Smits

Someren

et al. 2005

Chronobiology International

Self Cite

238

132

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To investigate whether ADHD-related sleep-onset insomnia (SOI) is a circadian rhythm disorder, we compared actigraphic sleep estimates, the circadian rest-activity rhythm, and dim light melatonin onset (DLMO) in ADHD children having chronic idiopathic SOI with that in ADHD children without sleep problems. Participants were 87 psychotropic-medication-naïve children, aged 6 to 12 yrs, with rigorously diagnosed ADHD and SOI (ADHD-SOI) and 33 children with ADHD without SOI (ADHD-noSOI) referred from community mental health institutions and pediatric departments of non-academic hospitals in The Netherlands. Measurements were 1 wk, 24 h actigraphy recordings and salivary DLMO. The mean (+/-SD) sleep onset time was 21:38 +/- 0:54 h in ADHD-SOI, which was significantly (p < 0.001) later than that of 20:49 +/- 0:49 h in ADHD-noSOI. DLMO was significantly later in ADHD-SOI (20:32 +/- 0:55 h), compared with ADHD-noSOI (19:47 +/- 0:49 h; p < 0.001). Wake-up time in ADHD-SOI was later than in ADHD-noSOI (p = 0.002). There were no significant between-group differences in sleep maintenance, as estimated by number of wake bouts and activity level in the least active 5 h period, or inter- and intradaily rhythm variability. We conclude that children with ADHD and chronic idiopathic sleep-onset insomnia show a delayed sleep phase and delayed DLMO, compared with ADHD children without SOI.

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“…Melatonin is only a mild hypnotic, and is therefore most useful in children with a wide range of circadian rhythm disturbances (including jet lag, blindness, central nervous system pathology, and, interestingly, ADHD) [52]. Melatonin has been studied in pediatric populations and has demonstrated safety and efficacy at shortening sleep-onset latency [53][54][55]. It is important to note that melatonin is a naturally occurring compound and in the United States is therefore not regulated by the FDA.…”

Section: Anxiety and Insomniamentioning

confidence: 99%

Psychopharmacology in Pediatric Oncology

Pinsky

Abrams

2012

Pediatric Psycho‐Oncology

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Melatonin for Chronic Sleep Onset Insomnia in Children: A Randomized Placebo-Controlled Trial

Cited by 35 publications

References 0 publications

Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial

Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial

Idiopathic Chronic Sleep Onset Insomnia in Attention‐Deficit/Hyperactivity Disorder: A Circadian Rhythm Sleep Disorder

Psychopharmacology in Pediatric Oncology

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