Melatonin for non-respiratory sleep disorders in visually impaired children

Khan, Sohil; Heussler, Helen; McGuire, Treasure; Dakin, Carolyn; Pache, David; Cooper, David; Norris, Ross; Flenady, Vicki; Charles, Bruce G.

doi:10.1002/14651858.cd008473

Cited by 1 publication

(2 citation statements)

References 33 publications

(14 reference statements)

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“…Melatonin may be used for the management of sleep disorders, such as insomnia and the disorder arising from night or shift work [Cardinali et al 2011;Fares, 2011;Hardeland et al 2008;Khan et al 2011;Malow et al 2012;Morin et al 2007;Ochoa-Sanchez et al 2011;Skene and Arendt, 2006;Srinivasan et al 2008Srinivasan et al , 2011a. When endogenous melatonin secretion is decreased, such as in people of advanced age or in those who use β blockers [Fares, 2011], or the natural circadian rhythm of melatonin is affected, such as in shift workers or people who are blind [Khan et al 2011], exogenous melatonin administration may improve the quality and duration of sleep. In patients with insomnia, melatonin seems to induce the onset of sleep, however its hypnotic action is mild.…”

Section: Melatonin and Sleep Disordersmentioning

confidence: 99%

“…2008, 2011a]. When endogenous melatonin secretion is decreased, such as in people of advanced age or in those who use β blockers [Fares, 2011], or the natural circadian rhythm of melatonin is affected, such as in shift workers or people who are blind [Khan et al . 2011], exogenous melatonin administration may improve the quality and duration of sleep.…”

Section: Melatonin and Sleep Disordersmentioning

confidence: 99%

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Therapeutic applications of melatonin

Kostoglou-Athanassiou

2013

Therapeutic Advances in Endocrinology

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Melatonin is a methoxyindole synthesized within the pineal gland. The hormone is secreted during the night and appears to play multiple roles within the human organism. The hormone contributes to the regulation of biological rhythms, may induce sleep, has strong antioxidant action and appears to contribute to the protection of the organism from carcinogenesis and neurodegenerative disorders. At a therapeutic level as well as in prevention, melatonin is used for the management of sleep disorders and jet lag, for the resynchronization of circadian rhythms in situations such as blindness and shift work, for its preventive action in the development of cancer, as additive therapy in cancer and as therapy for preventing the progression of Alzheimer's disease and other neurodegenerative disorders.

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