Melatonin for preventing primary headache: A systematic review

Pacheco, Rafael Leite; Latorraca, Carolina de Oliveira Cruz; Costa, Anderson Adriano Leal Freitas da; Martimbianco, Ana Luiza Cabrera; Pachito, Daniela Vianna; Riera, Rachel

doi:10.1111/ijcp.13203

Cited by 18 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…So giving melatonin at night before going to bed is the most appropriate because melatonin can stimulate sleep, where sleep disturbances are one of the precipitating factors for migraines. However, in these studies no further analysis was carried out so that the safety of the use of melatonin as migraine therapy still needs to be investigated further [4,19,27,32].…”

Section: Discussionmentioning

confidence: 99%

“…Based on these studies, a theory was formed that melatonin can play a role in the management of headaches, namely the relationship between the hypothalamus and melatonin in improving sleep quality and no serious side effects were found on melatonin administration [27,28]. The aim of this study was to provide a systematic review of the administration of melatonin as a treatment for migraine sufferers both in terms of attack frequency, intensity, duration, severity of headache attacks and also the side effects produced.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Melatonin as a treatment for migraine sufferers: a systematic review

Adnyana

Tertia

Widyadharma

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background Migraine is a primary headache with a prevalence of 12–20% in the world. Approximately 38% sufferers were indicated for prophylactic therapy, but only a small proportion (3–13%) received prophylactic therapy. The role of melatonin in migraine is to protect the brain against toxins through anti-free radical activity, inhibition of the release of inflammatory factors and neurotransmitters. Results This review uses the PRISMA protocol and uses source from Pubmed. A total of 142 articles were found according to the search strategy. 5 articles were collected with a randomized-controlled trial design that matched the inclusion criteria. Of the 5 articles, there were only 2 articles that proved significant where melatonin gave better results compared to placebo in migraine sufferers, especially in the frequency of attacks, duration, and reduction in the use of other analgesics. Based on the dose and duration of melatonin administration, although most use a dose of 3 mg melatonin with a duration of 2–3 months, this still needs to be investigated further because the available data are not sufficient. In addition, the use of melatonin before going to bed at night is said to be better because it is associated with the majority of side effects that occur, namely sleepiness. Conclusion Studies on melatonin and migraine with a randomized-controlled trial design are still limited so there is not enough evidence to support the administration of melatonin as a treatment for migraine sufferers, including the safety and side effects, especially for a long period of time.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Melatonin as a treatment for migraine sufferers: a systematic review

Adnyana

Tertia

Widyadharma

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

show abstract

“…прием мелатонина в дозе 5 мг приводил к уменьшению частоты приступов у 1 больного мигренью, 3 женщин с хронической головной болью напряжения и 1 мужчины с кластерной головной болью [38]. В проведенных с этого времени 4 рандомизированных контролируемых клинических исследованиях было показано, что назначение мелатонина у больных хронической мигренью сопровождается уменьшением числа болевых дней и количества принимаемых анальгетических препаратов [39]. Добавление мелатонина к стандартной схеме лечения (пропранолол плюс нортриптилин) имеет преимущество по сравнению с добавлением плацебо в отношении частоты приступов, интенсивности мигренозных атак и количества потребляемых анальгетиков.…”

Section: роль мелатонина в хронопатологии первичных головных болей и unclassified

Chronobiological features of primary headaches and the role of melatonin in the regulation of biological rhythms

2019

View full text Add to dashboard Cite

Frequency is considered as a key sign of the course of some forms of primary headaches (PH). One of the most prominent representatives is the hypnical and cluster headache, which predetermined their name. Clinical observations demonstrate a clear circadian rhythm and seasonal pattern of cluster headache (CH) and migraine (M) attacks. In accordance with modern concepts, the phenomenon of the periodicity of painful episodes of a number of forms of primary headaches is associated with dysfunction of the suprachiasmatic nucleus of the hypothalamus, the main pacemaker of biological rhythms. The connection of PH with chronopathology is confirmed by revealing the disturbances of melatonin secretion in CH and M. Melatonin has proven to be effective in treatment of these PH.

show abstract

“…Но исследования в данной области набирают большую популярность и доказывают успешность данного метода. А тот факт, что побочные эффекты препаратов, содержащих мелатонин, незначительны и редки, делает применение такого вида лечения ещё более привлекательным [11].…”

unclassified

Study of the Effect of Melatonin-Containing Drugs on the Intensity and Frequency of Primary Headache Attacks

Naumova,

Boynova,

Tokareva

2023

СПНО (MPSE)

View full text Add to dashboard Cite

Мигрень и головная боль напряжения превалируют по частоте встречаемости среди первичной головной боли и являются одной из главных причин посещения врача-невролога и врача семейной практики. В связи с этим возникает необходимость подбора адекватной терапии, которая могла бы купировать либо снизить частоту и интенсивность болевого синдрома. В последние 10-12 лет появилось много работ, касающихся функций мелатонина: способности непосредственно влиять на циркадные ритмы человека, в частности на цикл «сонбодрствование», антиоксидантной активности, функции снижения концентрации оксида азота, анальгетического эффекта. Сопоставив эти материалы с ключевыми моментами патогенеза заболеваний из группы первичной головной боли, можно предположить положительное действие препарата на симптоматику болезни. Именно поэтому анализ воздействия препаратов мелатонина на состояние пациентов представляет интерес для практического исследования. В данной статье представлены результаты изучения влияния препаратов, содержащих мелатонин, на частоту и интенсивность некоторых первичных форм головной боли. В ходе исследования было доказано положительное действие исследуемого препарата, что позволяет рекомендовать его в качестве препарата выбора для профилактического лечения некоторых форм головной боли в качестве монотерапии. Ключевые слова: мелатонин, меладапт, первичная головная боль, головная боль напряжения.

show abstract

Melatonin for preventing primary headache: A systematic review

Cited by 18 publications

References 25 publications

Melatonin as a treatment for migraine sufferers: a systematic review

Melatonin as a treatment for migraine sufferers: a systematic review

Chronobiological features of primary headaches and the role of melatonin in the regulation of biological rhythms

Study of the Effect of Melatonin-Containing Drugs on the Intensity and Frequency of Primary Headache Attacks

Contact Info

Product

Resources

About