2015
DOI: 10.1136/dtb.2015.10.0358
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Melatonin for sleep problems in children with neurodevelopmental disorders

Abstract: Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia). This may be associated with abnormally timed or inadequate secretion of melatonin, a naturally-occurring hormone involved in coordinating the body's sleep-wake cycle. Previously, we reviewed the use of a melatonin product licensed for primary insomnia in adults aged over 55 years. Here we review off-label and unlicensed use of … Show more

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Cited by 5 publications
(5 citation statements)
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“…There are a large number of non-pharmacological interventions aimed at improving various aspects of sleep disturbance in different clinical populations of children and adolescents. Clinical guidelines generally recommend that such interventions are tried before medication is prescribed 2 13 20 : in some cases, response to non-pharmacological interventions may be adequate, thus avoiding the need for melatonin. 21 In our subsample of patients treated with melatonin for less than 3 months, there was documented evidence in the clinical records to suggest that non-pharmacological interventions had been tried in just over two-thirds.…”
Section: Discussionmentioning
confidence: 99%
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“…There are a large number of non-pharmacological interventions aimed at improving various aspects of sleep disturbance in different clinical populations of children and adolescents. Clinical guidelines generally recommend that such interventions are tried before medication is prescribed 2 13 20 : in some cases, response to non-pharmacological interventions may be adequate, thus avoiding the need for melatonin. 21 In our subsample of patients treated with melatonin for less than 3 months, there was documented evidence in the clinical records to suggest that non-pharmacological interventions had been tried in just over two-thirds.…”
Section: Discussionmentioning
confidence: 99%
“…These standards were derived from good practice recommendations in a review of the use of melatonin for sleep problems in children with neurodevelopmental disorders that was published in the Drug and Therapeutics Bulletin. 2 …”
Section: Methodsmentioning
confidence: 99%
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