Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer’s Disease

Labban, Samah; Alshehri, Fahad S.; Kurdi, Maher; Alatawi, Yasser; Alghamdi, Badrah S.

doi:10.2147/dnnd.s291172

Cited by 15 publications

(7 citation statements)

References 71 publications

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“…These results are attractive, and are in line with the effect of melatonin administration on rats with induced memory impairment [ 40 ], including memory disruptions linked with steroid suppression by gonadectomy [ 41 , 42 ]. In fact, the common effect comprises limiting short-term memory impairment [ 43 , 44 ]. Moreover, effects on the long-term evaluation (as in the present work) have also been reported [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat

Barrón-González

Rosales‐Hernández

Abad-García

et al. 2022

IJMS

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Preclinical and clinical evidence supports melatonin and its analogues as potential treatment for diseases involving cognitive deficit such as Alzheimer’s disease. In this work, we evaluated by in silico studies a set of boron-containing melatonin analogues on MT1 and MT2 receptors. Then, we synthesized a compound (borolatonin) identified as potent agonist. After chemical characterization, its evaluation in a rat model with cognitive deficit showed that it induced ameliorative effects such as those induced by equimolar administration of melatonin in behavioral tests and in neuronal immunohistochemistry assays. Our results suggest the observed effects are by means of action on the melatonin system. Further studies are required to clarify the mechanism(s) of action, as the beneficial effects on disturbed memory by gonadectomy in male rats are attractive.

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Section: Resultsmentioning

confidence: 99%

Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat

Barrón-González

Rosales‐Hernández

Abad-García

et al. 2022

IJMS

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“…Additionally, research has demonstrated improvements in long-term recognition task performance in young, middle-aged, and elderly MLT-deficient mice (52). Labban et al examined the potential prophylactic effects of MLT against spatial memory deficits in a sporadic mouse model of AD induced by D-galactose and aluminum chloride (52). In a study conducted by Corpas et al, chronic administration of MLT was found to enhance learning and memory abilities in mice, increase exploratory behavior, and reduce anxiety associated with AD in 12-month-old mice (53).…”

Section: Therapeutic Potential Of Melatonin In Admentioning

confidence: 99%

Protective Roles of Melatonin in Alzheimer's Disease: A Review of Experimental and Clinical Research

Davodi-Boroujerdi,

Khayyat Naghadehi,

Nazari-Serenjeh

et al. 2024

Jentashapir J Cell Mol Biol

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: Alzheimer's disease (AD) stands as the most prevalent neurodegenerative disorder, marked by neuronal loss, synaptic dysfunction, atrophy in various brain regions, cognitive decline, dementia, the production of β-amyloid (Aβ) peptide, and the presence of neurofibrillary tangles. Melatonin, also known as N-acetyl 5-methoxy tryptamine, is a hormone regulated by circadian rhythms and plays a crucial role in certain neurodegenerative conditions, including AD. In individuals with AD, alterations have been observed in the pineal gland hormone melatonin (MLT), the activity of enzymes associated with MLT synthesis, and the density of MT1 receptors in the suprachiasmatic nucleus (SCN) of the hypothalamus. The growing body of literature indicates a rising interest in utilizing MLT for AD intervention. Melatonin has shown several potential benefits in AD, such as mitigating mitochondrial dysfunction, reducing Aβ toxicity, scavenging free radicals, and even ameliorating circadian dysregulation, which includes addressing issues like sundowning and sleep disturbances. Recent studies suggest that MLT might serve as a potential biomarker for assessing the severity and progression of AD. This paper aimed to provide an overview of recent research on three key aspects: (1) MLT physiology, (2) the role of MLT in the learning and memory processes, and (3) an exploration of studies investigating the role of MLT in AD.

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“…Recent researches have explored its potential therapeutic benefits in sleep disorders, depression, anxiety, and drug addiction (Turek and Gillette, 2004;Papp et al, 2006;Cardinali et al, 2012;Onaolapo and Onaolapo, 2018;Alghamdi and Alshehri, 2021). Additionally, studies have investigated its efficacy in treating cardiovascular diseases, cancer, and Alzheimer's disease (Sun et al, 2016;Li et al, 2017;Labban et al, 2021). Evidence also suggests that melatonin possesses anti-aging properties and can promote better sleep (Pereira et al, 2020;Bocheva et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats

Hakami,

Alghamdi,

Alshehri

2024

Front. Pharmacol.

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Background:Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synthetic opioid analgesic, is used to manage moderate to severe pain but has a high potential for abuse and dependence. Studies have shown that melatonin could be a potential modulator to reduce tramadol addiction.Methods:Male Wistar rats were used to investigate the effect of melatonin on tramadol-induced place preference. The rats were divided into four groups: control, tramadol, tramadol + melatonin (single dose), and tramadol + melatonin (repeated doses). Tramadol was administered intraperitoneally at 40 mg/kg, while melatonin was administered at 50 mg/kg for both the single dose and repeated-dose groups. The study consisted of two phases: habituation and acquisition.Results:Tramadol administration produced conditioned place preference (CPP) in rats, indicating rewarding effects. However, melatonin administration blocked tramadol-induced CPP. Surprisingly, repeated doses of melatonin were ineffective and did not reduce the expression of CPP compared to that of the single dose administration.Conclusion:The study suggests that melatonin may be a potential therapeutic option for treating tramadol addiction. The results indicate that melatonin attenuates the expression of tramadol-induced CPP, supporting its uses as an adjunct therapy for managing tramadol addiction. However, further studies are needed to investigate its effectiveness in humans.

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Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer’s Disease

Cited by 15 publications

References 71 publications

Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat

Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat

Protective Roles of Melatonin in Alzheimer's Disease: A Review of Experimental and Clinical Research

Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats

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