Melatonin in Childhood Epilepsy and in Child Neurology

Paprocka, Justyna; Kijonka, Marek; Sokół, Maria

doi:10.5772/intechopen.80005

Cited by 3 publications

(5 citation statements)

References 106 publications

(194 reference statements)

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“…Seizures reportedly occur more frequently in phase 2 of NREM (61-68%), phases 3 and 4 of NREM (9-14%), and the REM phase (0-5%). 20 Circadian rhythm is also disorganized in children with epilepsy due to changes in the wake-sleep cycle controlled by the suprachiasmatic nucleus (SCN) in the anterior hypothalamus. Melatonin hormone secretion pattern is disturbed, with high concentrations at night or after a seizure.…”

Section: Discussionmentioning

confidence: 99%

“…Disturbed melatonin secretion patterns change the wake-sleep cycle and wake-promoting signal of the SCN, thus causing sleep disorders. [20][21] Epilepsy increases sleep onset latency or sleep onset delay, increases the number and duration of wakefulness episodes after sleep onset, decreases sleep efficiency, reduces spindle sleep, and increases REM phase abnormalities. A study in India showed that seizures in children with epilepsy had significant correlations with wake disorders and pathological sleep.…”

Section: Discussionmentioning

confidence: 99%

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Sleep disorders and associated factors in children with cerebral palsy

Patery¹,

Sunartini

Sutomo

2021

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Background Sleep disorders are a condition affecting quality and quantity of sleep. Children with cerebral palsy (CP) have higher risk of sleep disorders than those with no chronic disease. Objective To determine the prevalence and factors associated with sleep disorders in children with CP. Methods We conducted an analytic, observational study with cross-sectional design in children aged 4-10 years with CP. Subjects were recruited consecutively; children with chronic diseases (cardiovascular, malignancy, chronic obstructive pulmonary disease, and diabetes mellitus) were excluded from the study. Primary data including sociodemographics, intensity of physiotherapy outside Sardjito General Hospital (SGH), sleep hygiene, and sleep disorders were collected from the Children’s Sleep Habit Questionnaire (CSHQ). Secondary data were acquired from medical records, such as type of CP, severity of motor function impairment, presence of epilepsy, intensity of physiotherapy performed at SGH, as well as anti-epileptic, anti-spastic, and sleep-affecting medicines. Results We found sleep disorders in 64 of 75 (85%) subjects, mostly bedtime resistance (66%). Spastic quadriplegia (OR=3.63; 95%CI 1.82 to15.94) and presence of epilepsy (OR=7.82; 95%CI 1.53 to 39.84) were significantly associated with sleep disorders in children with CP aged 4-10 years. Conclusion Sleep disorders are common in children with CP, with the majority experiencing bedtime resistance. Sleep disorders are more prevalent in subjects with spastic quadriplegia and epilepsy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sleep disorders and associated factors in children with cerebral palsy

Patery¹,

Sunartini

Sutomo

2021

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“…Melatonin appears to reduce seizure activity in human investigations of temporal‐lobe epilepsy (Albertson et al., 1981 ; Borowicz et al., 1999 ; Champney et al., 1996 ; de Lima et al., 2005 ; Mevissen & Ebert, 1998 ; Pévet, 2022 ; Rosenstein et al., 1990 ). Melatonin does not appear to have an impact on the normal electroencephalogram (EEG) (Paprocka et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin's anticonvulsant action has been linked to some different pathways. Its antioxidant, antiexcitotoxic, and free radical scavenging activities in the central nervous system (CNS) provide neuroprotection (Goldberg‐Stern et al., 2012 ; Gupta, Gupta, et al., 2004 ; Gupta, Aneja, et al., 2004 ; Gupta et al., 2005 ; Paprocka et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of add‐on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic‐clonic seizures alone in adult patients: Cross‐sectional, randomized, double‐blind, placebo‐controlled clinical trial

et al. 2023

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Background Effective treatment of epilepsy is a major challenge in the field of neurology. Studies have suggested that melatonin can work in epilepsy with a good safety profile. Objectives This study was performed to determine the effectiveness of melatonin in seizure outcomes, as well as the quality of sleep in patients with generalized epilepsy. Methods In this cross‐over clinical trial study, 60 patients with epilepsy with idiopathic generalized tonic‐clonic seizures alone (EGTCS) and under valproic acid treatment received either melatonin or placebo with a washout period of 2 weeks intermittently. Outcome variables included a reduction in the severity and frequency of epilepsy besides improvement in electroencephalogram (EEG) abnormalities and sleep quality. Results By adding melatonin, a decrease in the mean severity score of epilepsy (according to the Chalfont questionnaire) was 32.33 ± 9.24, while it was 5.58 ± 14.28 in treatment with placebo (p = .002). Evaluation of the number of attacks and EEG results did not disclose any therapeutic efficacy in treatment with melatonin versus placebo. The quality of sleep improved in 40% (first round) and 53.4% (second round) of subjects who received melatonin (p < .001). Conclusions Considering that the addition of melatonin to routine anti‐seizure treatment was effective in reducing the severity of epilepsy and improving sleep quality, it seems that melatonin can be useful as an adjunct therapy for EGTCS in well‐defined circumstances.

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“…In our previous studies, we showed that melatonin secretion in children with hypoxic ischemic encephalopathy (HIE) is significantly disturbed, even stronger than in epilepsy. Its characteristic features, as seen from the blood sampling [ 3 , 4 ], are the delayed melatonin phase release and the shift of the DLMO parameters to the later morning hours.…”

Section: Introductionmentioning

confidence: 99%

Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy

Kapek

Paprocka

Kijonka

et al. 2020

International Journal of Endocrinology

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Purpose. In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. The logit model was fitted to the data to obtain the salivary dim light melatonin onsets (DLMOs), and the results were compared with the values estimated from the classic threshold method with a linear interpolation and those previously published for the blood measurements. Materials and Methods. 9 patients suffering from HIE aged from 65 to 80 months were included in the study. The melatonin levels were assessed by a radioimmunoassay (RIA). The diurnal melatonin secretion was estimated using a nonlinear least squares method. Student’s t-test and the Mann–Whitney U test were used for the comparisons of the obtained parameters. Results. The circadian profiles of the melatonin secretion for both calculation methods do not differ statistically. The DLMO parameters obtained in the blood and saliva samples in children with hypoxic ischemic encephalopathy were similar.

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Melatonin in Childhood Epilepsy and in Child Neurology

Cited by 3 publications

References 106 publications

Sleep disorders and associated factors in children with cerebral palsy

Sleep disorders and associated factors in children with cerebral palsy

Effect of add‐on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic‐clonic seizures alone in adult patients: Cross‐sectional, randomized, double‐blind, placebo‐controlled clinical trial

Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy

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