Melatonin in Chronic Renal Failure

Viljoen, Margaretha; Steyn, M. E.; Rensburg, B.W.J. Van; Reinach, S. G.

doi:10.1159/000186729

Cited by 43 publications

(23 citation statements)

References 17 publications

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“…People undergoing dialysis have been observed to lose a normal night time peak of melatonin production (Viljoen et al 1992). This hormone is important to the maintenance of the circadian cycle of sleep (Kim et al 2015).…”

Section: Discussionmentioning

confidence: 99%

The Circadian Clock in the Regulation of Renal Rhythms

Solocinski

Gumz

2015

J Biol Rhythms

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Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood pressure, renal blood flow, glomerular filtration rate, and sodium and water excretion have been documented for decades, if not longer. Recent studies on the role of circadian clock proteins in the regulation of a variety of renal transport genes suggest that the molecular clock in the kidney controls circadian fluctuations in renal function. The circadian clock appears to be a critical regulator of renal function with important implications for the treatment of renal pathologies which include chronic kidney disease and hypertension. The development, regulation, and mechanism of the kidney clock are reviewed here.

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Section: Discussionmentioning

confidence: 99%

The Circadian Clock in the Regulation of Renal Rhythms

Solocinski

Gumz

2015

J Biol Rhythms

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“…In addition to the clinical associations with these sleep disorders, advanced CKD has been linked to the suppression of the melatonin surge that is integrally linked to the regulation of the circadian rhythm [32,33]. Further evidence that advanced CKD exacerbates sleep disturbance is the observation that kidney transplantation and long nocturnal hemodialysis partially correct sleep apnea in dialysis patients [34,35,36].…”

Section: Discussionmentioning

confidence: 99%

Sleep Duration and Chronic Kidney Disease: Analysis of the National Health Interview Survey

Salifu¹,

Tedla²,

Pandey³

et al. 2014

Cardiorenal Med

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Background: Patients with chronic kidney disease (CKD) have a high prevalence of sleep disorders. The association between sleep duration and self-reported CKD was examined in a population of Americans who participated in a national survey over a 3-year period. Study Design: A cross-sectional study using survey data from theNational Health Interview Survey (NHIS) from the year 2004-2006 was carried out. A retrospective examination of data from acommunity-based survey of 128,486 noninstitutionalized US civilian residents over the age of 18 years was conducted. Self-reportedCKD was defined as having ‘weak or failing kidneys'. The sleep duration was defined by a self-reported estimate of habitual sleep duration. Results: The prevalence of participants self-reporting kidney disease was higher in those with short (≤6 h per night) and long (≥8 h per night) sleep durations when compared to those sleeping 7 h per night. Self-reported information about sleep, demographic information, and information on comorbidities were assessed using standardized validated questionnaires which reported no kidney disease. A multivariate logistic regression analysis showed increased odds of self-reported kidney disease in study participants with both short and long sleep durations compared to healthy sleepers (sleeping >7-8 h per night). Observational data do not permit examination of causality, although possible confounders in observations of interest can be adjusted. Conclusion: AmongAmericans surveyed in the NHIS (2004-2006), those with short or long sleep duration had higher odds of reporting that they had CKD. i 2014 S. Karger AG, Basel

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“…[45] Evidence is not conclusive about the source of sleep disturbance in these patients. However, absence of a nocturnal rise in melatonin concentration in daytime HD patients has been documented,[6] suggesting that it may be related to the degree of chronic kidney disease. [7] In contrast, some studies on HD patients have shown a relationship between supra-physiological concentrations of melatonin and its major metabolite, 6-sulfatoxymelatonin, with a diurnal rhythm in spite of insomnia, delayed sleep onset, night-time arousals and restless-leg syndrome.…”

Section: Introductionmentioning

confidence: 99%

Melatonin improves sleep quality in hemodialysis patients

et al. 2013

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Disturbed sleep is common in end-stage renal disease (ESRD). Exogenous melatonin has somniferous properties in normal subjects and can improve sleep quality (SQ) in several clinical conditions. Recent studies have shown that melatonin may play a role in improving sleep in patients undergoing dialysis. The goal of the present study was to assess the effect of exogenous melatonin administration on SQ improvement in daytime hemodialysis patients. Lipid profile and the required dose of erythropoietin (EPO) are also reported as secondary outcomes. In a 6-week randomized, double-blind cross-over clinical trial, 3 mg melatonin or placebo was administered to 68 patients at bedtime. A 72-h washout preceded the switch from melatonin to placebo, or vice versa. SQ was assessed by the Pittsburgh sleep quality index (PSQI). Sixty-eight patients completed the study protocol and were included in the final analysis. Melatonin treatment significantly improved the global PSQI scores (P < 0.001), particularly subjective SQ (P < 0.001), sleep efficiency (P = 0.005) and sleep duration (P < 0.001). No differences in sleep latency and daytime sleepiness were observed. Melatonin also increased the high-density lipoprotein (HDL) cholesterol (P = 0.003). The need for EPO prescription decreased after melatonin treatment (P < 0.001). We conclude that melatonin can improve sleep in ESRD. The modest increase in HDL cholesterol and decrease in the EPO requirement are other benefits associated with this treatment

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Melatonin in Chronic Renal Failure

Cited by 43 publications

References 17 publications

The Circadian Clock in the Regulation of Renal Rhythms

The Circadian Clock in the Regulation of Renal Rhythms

Sleep Duration and Chronic Kidney Disease: Analysis of the National Health Interview Survey

Melatonin improves sleep quality in hemodialysis patients

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