Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Nduhirabandi, Frederic; Maarman, Gerald J.

doi:10.3390/molecules23071819

Cited by 48 publications

(45 citation statements)

References 142 publications

(247 reference statements)

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“…Both MTNR1A (MT1) and MTNR1B (MT2) are present in human brown tissue adypocytes indicating a possible involvement of MTNR1B in adipocyte physiology (106). A study investigating mechanisms regulating hibernation in European hamster (Cricetus cricetus) reported altered gene expression of MTNR1B (named MT2) in brown adipose tissue during the hibernation cycle (107). Daily rhythmicity with higher expression during the day were observed for mtnr1a and mtnr1d in the liver of rabbitfish (Signatus guttatus) which is involved in the maintenance of lipid homeostasis (92,93).…”

Section: Day/night Tissue Expression Of Melatonin Receptors In Femalementioning

confidence: 99%

New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts

2020

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In order to improve our understanding of melatonin signaling, we have reviewed and revised the evolutionary history of melatonin receptor genes (mtnr) in vertebrates. All gnathostome mtnr genes have a conserved gene organization with two exons, except for mtnr1b paralogs of some teleosts that show intron gains. Phylogeny and synteny analyses demonstrate the presence of four mtnr subtypes, MTNR1A, MTNR1B, MTNR1C, MTNR1D that arose from duplication of an ancestral mtnr during the vertebrate tetraploidizations (1R and 2R). In tetrapods, mtnr1d was lost, independently, in mammals, in archosaurs and in caecilian amphibians. All four mtnr subtypes were found in two non-teleost actinopterygian species, the spotted gar and the reedfish. As a result of teleost tetraploidization (3R), up to seven functional mtnr genes could be identified in teleosts. Conservation of the mtnr 3R-duplicated paralogs differs among the teleost lineages. Synteny analysis showed that the mtnr1d was conserved as a singleton in all teleosts resulting from an early loss after tetraploidization of one of the teleost 3R and salmonid 4R paralogs. Several teleosts including the eels and the piranha have conserved both 3R-paralogs of mtnr1a, mtnr1b, and mtnr1c. Loss of one of the 3R-paralogs depends on the lineage: mtnr1ca was lost in euteleosts whereas mtnr1cb was lost in osteoglossomorphs and several ostariophysians including the zebrafish. We investigated the tissue distribution of mtnr expression in a large range of tissues in medaka. The medaka has conserved the four vertebrate paralogs, and these are expressed in brain and retina, and, differentially, in peripheral tissues. Photoperiod affects mtnr expression levels in a gene-specific and tissue-specific manner. This study provides new insights into the repertoire diversification and functional evolution of the mtnr gene family in vertebrates.

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Section: Day/night Tissue Expression Of Melatonin Receptors In Femalementioning

confidence: 99%

New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts

2020

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“…Osteoporosis and several other diseases increase in prevalence with age, simultaneous with the age-related drop in peak nocturnal melatonin secretion. Several articles have confirmed that this coincidence is not accidental, with the loss of melatonin being related to aggravation or an increase in the incidence of the ailment [13,169]. Thus, during aging, the drop in the nocturnal melatonin peak is associated with a rise in bone resorption, suggesting that melatonin may act as an endogenous osteoclast inhibitor [178].…”

Section: Apoptosismentioning

confidence: 99%

“…Heart failure is also a multifactorial syndrome that increases in prevalence with age [169]. Heart failure involves cardiomyocyte apoptosis; this is a major physiopathological feature and melatonin reverses it [56,167,179,[281][282][283].…”

Section: Apoptosismentioning

confidence: 99%

“…Fibrosis, the pathological accumulation of collagen and extracellular matrix (ECM), interferes with the physiology of organs. Damaging fibrosis is most commonly reported in the lung [203], heart [169], liver [104], and kidney [172] but it occurs in other situations where inflammation is rampant [94] as well as in the form of adhesions [14] among organs after surgical intervention, infection, oxidative stress, etc. Whereas there is some evidence that fibrosis may be reversible, particularly in the early stages, advanced fibrosis is associated with end stage disease, organ failure and death.…”

Section: Collagen and Extracellular Matrixmentioning

confidence: 99%

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Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implications

Reíter¹,

Sharma²,

Rosales-Corral³

et al. 2020

Human Perspectives in Health Sciences and Technology

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IntroductionSome system-wide functions/aspects of melatonin were identified decades ago, e.g., regulation of seasonal reproduction [51,200,201], photoperiodic control of pineal melatonin synthesis [122,227], sleep initiation [31,117], antioxidant actions [67, 197], circadian rhythm modulation [208,279], cancer inhibition [27,86,163], etc. These aspects of melatonin are generally well known by the scientists working in the field, although the detailed mechanisms of these actions, in most cases, require further clarification. These functions are not discussed in detail in the current review, but they may be mentioned when they are germane to the discussion. Also, the functions of melatonin in plants [18,61,62,194] are not considered even though

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“…Another attribute of melatonin which makes it special among other antioxidants is that while interacting with free radicals it does not turn into a prooxidant by losing an electron. [6][7][8] In current literature, there are many studies revealing the cardioprotective effect of melatonin [9][10][11][12] alongside its therapeutic effects on several other diseases. Simko et al 10 showed that melatonin administration significantly treated hypertension and increased oxidative stress in left ventricle and aorta, left ventricular hypertrophy, and fibrosis caused by continuous exposure to light.…”

Section: Introductionmentioning

confidence: 99%

Melatonin ameliorates periodontitis‐related inflammatory stress at cardiac left ventricular tissues in rats

Köse

Bayrakdar

Akyıldız

et al. 2020

Journal of Periodontology

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Background: The aim of this experimental rat study was to investigate the potential inflammatory effects of periodontitis on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-melatonin (Ep-Mel). Experimental periodontitis was induced by placing and maintaining 3.0 silk ligatures at a peri marginal position on the left and right mandibular first molars for 5 weeks. Afterward, following the removal of ligatures, melatonin (10 mg/body weight) to Ep-Mel group, and vehicle (saline) to Ep and control groups were administered intraperitoneally for 14 days. On the first day of the eighth week, mandibular and cardiac left ventricular tissue samples were obtained following the euthanasia of the rats in all groups. Alveolar bone loss measurements were made on histological and microcomputed tomographic slices. Cardiac tissue levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), matrix metalloproteinase-9 (MMP-9), and cardiac Troponin-T (cTnT) were evaluated by appropriate biochemical methods. Results: Measurements made on the histological and microcomputed tomographic slices showed that melatonin significantly limits the ligature-induced periodontal tissue destruction (P <0.01). In addition, melatonin was detected to cause a significant decrease of MDA, MMP-9, and cTnT levels which were found to be significantly higher on rats with Ep (P <0.05) while having no significant effect on antioxidant levels (GSH, SOD, and CAT) (P >0.05). Conclusion: Melatonin might be regarded as an important supportive therapeutic agent to reduce the early degenerative changes and possible hypertrophic remodeling at cardiac left ventricular tissues provoked by periodontitis-related bacteria and/or periodontal inflammation.

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Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Cited by 48 publications

References 142 publications

New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts

New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts

Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implications

Melatonin ameliorates periodontitis‐related inflammatory stress at cardiac left ventricular tissues in rats

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