Melatonin in Psychiatric Disorders: A Review on the Melatonin Involvement in Psychiatry

Pacchierotti, Claudia; Iapichino, S.; Bossini, Letizia; Pieraccini, Fulvio; Castrogiovanni, Paolo

doi:10.1006/frne.2000.0202

Cited by 196 publications

(92 citation statements)

References 92 publications

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“…Our results, showing lower platelet 5-HT levels in depressed patients compared to healthy control subjects within the same period, could be a direct consequence of the altered melatonin production and/or disruption of melatonin's biological functions present in depressive disorders. Although in our study we did not measure the plasma melatonin levels, literature data shows increased secretion of melatonin in depressed patients [14][15][16][17][18], suggesting an interaction of melatonin with the 5-HT system.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin regulates biological rhythms and levels of biomolecules that exert various peripheral actions, thus affecting many critical processes [13]. Various studies have shown altered melatonin secretion in depression [14][15][16][17][18][19], seasonal affective disorder (SAD) [20][21], schizophrenia [22][23][24][25][26], panic disorder [27], obsessive-compulsive disorder [17,28] and Alzheimer's disease [29], suggesting an interaction of melatonin with the central neurotransmitter systems. Goergen et al (2002) have shown that light-controlled rhythm could be the primary regulator of neuronal proliferation and that previously demonstrated hormonal and activitydriven influences over neurogenesis may be the secondary events in a complex circardian control pathway [30].…”

Section: Introductionmentioning

confidence: 99%

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The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia

Ljubičić

Stipčević

Pivac

et al. 2007

Journal of Photochemistry and Photobiology B: Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia

Ljubičić

Stipčević

Pivac

et al. 2007

Journal of Photochemistry and Photobiology B: Biology

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“…34 Abnormal circadian rhythms have been described in patients with affective disorders. Several studies have also shown abnormal concentrations of melatonin in bipolar patients and differing levels of plasma melatonin in the manic and depressive phases of the disorder (reviewed by Pacchierotti et al 35 ). The subtelomeric region of chromosome 4q35 has previously proven difficult to characterise, probably due to the complex arrangement of redundant and novel repetitive elements.…”

Section: Discussionmentioning

confidence: 99%

A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35

et al. 2002

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Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar susceptibility and pathogenesis are yet to be identified. Genetic linkage analysis has identified a bipolar disorder susceptibility locus on chromosome 4q35, and the interval harbouring this susceptibility gene has been narrowed to a size that is amenable to positional cloning. We have used the resources of the Human Genome Project (HGP) and Celera Genomics to identify overlapping sequenced BAC clones and sequence contigs that represent the region implicated by linkage analysis. A combination of bioinformatic tools and laboratory techniques have been applied to annotate this DNA sequence data and establish a comprehensive transcript map that spans approximately 5.5 Mb. This map encompasses the chromosome 4q35 bipolar susceptibility locus, which localises to a 'most probable' candidate interval of approximately 2.3 Mb, within a more conservative candidate interval of approximately 5 Mb. Localised within this map are 11 characterised genes and eight novel genes of unknown function, which together provide a collection of candidate transcripts that may be investigated for association with bipolar disorder. Overall, this region was shown to be very gene-poor, with a high incidence of pseudogenes, and redundant and novel repetitive elements. Our analysis of the interval has demonstrated a significant difference in the extent to which the current HGP and Celera sequence data sets represent this region.

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“…[114] Yapılan bir çalışmada, plazma melatonin seviyesi manik atak süresince depresif atağa göre yüksek olduğu saptanmıştır. [115] Bunun muhtemel nedeninin adrenerjik sistemle ilgili olduğu düşünülmektedir. [116] Şizofreni ile melatonin düzeyleri arasında neden sonuç ilişkisi ile ilgili net bir veri yoktur.…”

Section: Melatonin Ve Psikiyatrik Hastalıklarunclassified

An Overview On Melatonin Hormone

Özçeli̇k¹,

Erdem²,

Bolu³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETMelatonin hormonu, son yıllarda tüm dünyada gittikçe artan bir ilgiyle araştı-rılmaktadır. Ana görevi vücudun biyolojik saatini koruyup ritmini ayarlamak olan melatonin, vücudun birçok biyolojik ve fizyolojik süreçlerinde yer alır. Hücrelerin yenilenmesi, bağışıklık siteminin güçlenmesi, uyku ritminin ve vücut ısısının düzenlenmesi diğer önemli görevleri arasındadır. Lipofilik özel-liği nedeniyle bilinen en güçlü antioksidandır. Bu özelliği sayesinde tüm vücut alanlarına ulaşabilmekte ve kan-beyin bariyerini geçebilmektedir. Uyku problemi olan kişilerde melatoninin düşük düzeyde bulunması, ilaç olarak kullanımını akla getirmektedir. Yapılan uygulamaların ardından melatoninin uyku total süresini değiştirmeden uyku kalitesini artırdığı belirlenmiştir. Ancak yaygın araştırılmasına rağmen melatoninin işlevleri halen tamamıyla bilinmemektedir. Bu nedenle melatonin ile ilgili mevcut bilgilerin gözden geçirilmesi, bu alanda araştırma yapanlara rehberlik edecektir. Anahtar Sözcükler: Melatonin, uyku, biyolojik saat, antioksidan. ABSTRACTIn recent years, there is a growing interest in melatonin all over the world. The main task of protecting the body's biological clock, which set the rhythm of melatonin, involves many biological and physiological processes of the body. Cell renewal, strengthening of the immune system and body temperature regulation are other tasks of melatonin. Melatonin, with its lipophilic property, is the most powerful antioxidant as it can reach all body areas and can easily pass the blood-brain barrier. The fact that individuals with low levels of melatonin have sleep problems lead to the consideration of melatonin as a therapeutic medicine in this field. The detailed researches have shown that melatonin can improve sleep quality without changing the total duration of sleep. Nevertheless, despite high number of researches done, the functions ©2013, Psikiyatride Güncel Yaklaşımlar eISSN:1309-0674 pISSN:1309-0658

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Melatonin in Psychiatric Disorders: A Review on the Melatonin Involvement in Psychiatry

Cited by 196 publications

References 92 publications

The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia

The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia

A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35

An Overview On Melatonin Hormone

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