Melatonin-induced phase and dose responses in a diurnal mammal, <i>Funambulus pennantii</i>

Soni, Sanjeev Kumar; Kumar, Dhiraj; Singaravel, Muniyandi

doi:10.1080/07420528.2020.1758127

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…Essentially, melatonin has been significantly found in substantive amounts in vegetables, including barley, walnuts, tomatoes, rice, and olives [61]. For example, taking vegetables in the morning has been linked to the higher excretion of urinary aMT6s [62,63]. There were similar statistics in Japanese women, where a similar increased mean for the urinary aMT6s in a high intake of vegetables than the ones with the lowest consumption, essentially by 16% [59,64].…”

Section: Dietary Intakementioning

confidence: 96%

“…The increasing level of melatonin is more likely to result from the stimulatory effects of the consumed products instead of the absorbed dietary food enriched with melatonin [65,66]. Melatonin is usually found in milk products, especially those produced during the night [62,67]. Therefore, it is imperative to conclude that nighttime lactation has been associated with various physiological importance attached to it as part of the infant's diet [61].…”

Section: Dietary Intakementioning

confidence: 99%

“…Changing posture usually affects the blood volume since there is redistribution of blood during changes in posture, particularly from supine to standing [69]. Studies have suggested a significant variation in the antigravity muscle activities once there are changes in posture, and the muscles are critical in the vascular and vasomotor activity [60,62].…”

Section: Posturementioning

confidence: 99%

“…Atenolol has been linked to significant light-induced phase delays in the onset of melatonin in humans [78]. Psychotropic and antidepressant drugs have been associated with changes in pineal functions and melatonin levels, as shown in Figure 1 [62,69]. Various types of selective serotonin inhibitors, SSRI, including fluvoxamine, result in a notable rise in plasma melatonin concentrations.…”

Section: Drugsmentioning

confidence: 99%

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Characteristic, Synthesis, and Non-Photic Regulation of Endogenous Melatonin

Albreiki¹

2022

Melatonin - Recent Updates

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Several researchers have confirmed that the melatonin hormone is significant to the body’s circadian rhythm, hence, the need to explore the connection between the two aspects. The circadian rhythm is a natural endogenous process that controls essential body functions as it affects hormone release, body temperature, sleep patterns, and eating habits. In that view, the circadian rhythm relies on melatonin to synchronize the night and day cycles. Melatonin plays a significant role in controlling the circadian rhythm by facilitating quality sleep at night and alertness during the day. In effect, understanding the acute non-image-forming visual effects of melatonin will help derive ways to ensure the circadian rhythms operate efficiently for healthy body functions.

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Section: Dietary Intakementioning

confidence: 96%

Section: Dietary Intakementioning

confidence: 99%

Section: Posturementioning

confidence: 99%

Section: Drugsmentioning

confidence: 99%

See 2 more Smart Citations

Characteristic, Synthesis, and Non-Photic Regulation of Endogenous Melatonin

Albreiki¹

2022

Melatonin - Recent Updates

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“…World FDA organization (Food & Drug Administration) categorized melatonin as dietary supplements, not drugs, since melatonin can be found in many food products (especially plants -phytomelatonin), thou melatonin usage FDA does not regulate [18,19]. Many researches supported that melatonin had not any side effects in case of usage wide range of dose (0,1 mg/kg -100 mg/kg) [20,21]. Moreover, in case of melatonin use, it's necessary totake account of melatonin intervention time, because there aredifferent sensitivity (density, affinity) of melatonin receptors during the day -chrobiological approach an integral part in melatonin therapy [22].…”

mentioning

confidence: 99%

Morpho-functional state of rats pineal gland and suprachismatic nucleus of hypothalamus after different regimes of exogenous melatonin administration

Kalmukova

Dzerzhynsky

2020

BTSNUKSB

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In modern society increase of digitalization associated with grown exceed level of light at night – a new type of pollution. Presence of light at night inhibited endogenous melatonin synthesis by pineal gland, that influence on circadian system work cycles, so organism oftenbroken regime of wake/sleep, meals, physical activity. Also, a lack of melatonin in some certain time of dayand low melatonin concentration both, were shown take some intervention in diseases development through incorrect regulation of clock-depended genes expression. In connect with this, some latest clinical protocol in therapy or clinical trials of many different pathologies (for example, insomnia, metabolic syndrome, cardiovascular diseases, central nervous and immune system trouble, cancer, viral infection, etc.) include exogenous melatonin usage. As melatonin perform his function via endocrine and paracrine ways in variety types of cell, his application take place in wide range of doses and in different time of day (chronotherapeutic approach). Therefore, important to control state of circadian system central elements – pineal gland (main producer of endogenous melatonin) and suprachiasmatic nucleus (SCN) of hypothalamus (central pacemaker of circadian rhythm) in conditionsof exogenous melatonin treatment. Thus, the main goal of our research were analysis of rats pineal gland and hypothalamic SCN morpho-functional state after different time (morning, evening and continuously with drinking water) melatonin daily administration. Melatonin was administered by gavage for 7 weeks in dose 30 mg/kg 1 h before lights-off (M ZT11, evening), or 1 h after lights-on (M ZT01, morning), or continuously with drinking water during day-night period (MW). After melatonin use only in MW group pineal gland demonstrates changes in morphology (pinealocytes nucleus had mild basophilic color) and morphometric (increased cross-sectional area of the pinealocytes nucleus in compare with control group) analysis data. Besides, some similar changes were observed in SCN: the cross-sectional area of the SCN neurons nucleus grown in case of usage each of regime melatonin administration, while morphology characteristic remains without any alteration. In general, it suggesting about having by melatonin non-inhibiting features in context of circadian system feedback loop and supposing wide potential for melatonin use with absent huge side effect on central elements of above mentioned system.

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