Melatonin Induced Pigment Translocations in Channa punctatus (Ham.) Melanophores May be Mediated Through Specific Receptors

Mubashshir, Muhammad; Shah, Khurshid Ahmad; Sumoona, Safia; Shei, Irfan Ahmed; Ayajuddin, M.; Ovais, M.

doi:10.5567/pharmacologia.2014.241.246

Cited by 2 publications

(1 citation statement)

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“…We found different sets of mtnr genes expressed in the integument of teleost species: mtnr1b and mtnr1d in sole (Solea senegalensis) (94), mtnr1a and mtnr1d in mudskipper (Boleophthalmus pectinirostris) (95), mtnr1aaα, mtnr1aaβ, mtnr1ab, and mtnt1b in Atlantic salmon (10) and mtnr1b, mtnr1c, and mtnr1d in goldfish (8). Melatonin induces hypopigmentation in several ostariophysian species, by stimulating aggregation of melanophores partially through stimulation of Mtnr1a and Mtnr1b (111)(112)(113). In mammals, both MTNR1A and MTNR1B are expressed in the skin with different distributions depending of the species [for review see (114)].…”

Section: Day/night Tissue Expression Of Melatonin Receptors In Femalementioning

confidence: 99%

New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts

2020

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In order to improve our understanding of melatonin signaling, we have reviewed and revised the evolutionary history of melatonin receptor genes (mtnr) in vertebrates. All gnathostome mtnr genes have a conserved gene organization with two exons, except for mtnr1b paralogs of some teleosts that show intron gains. Phylogeny and synteny analyses demonstrate the presence of four mtnr subtypes, MTNR1A, MTNR1B, MTNR1C, MTNR1D that arose from duplication of an ancestral mtnr during the vertebrate tetraploidizations (1R and 2R). In tetrapods, mtnr1d was lost, independently, in mammals, in archosaurs and in caecilian amphibians. All four mtnr subtypes were found in two non-teleost actinopterygian species, the spotted gar and the reedfish. As a result of teleost tetraploidization (3R), up to seven functional mtnr genes could be identified in teleosts. Conservation of the mtnr 3R-duplicated paralogs differs among the teleost lineages. Synteny analysis showed that the mtnr1d was conserved as a singleton in all teleosts resulting from an early loss after tetraploidization of one of the teleost 3R and salmonid 4R paralogs. Several teleosts including the eels and the piranha have conserved both 3R-paralogs of mtnr1a, mtnr1b, and mtnr1c. Loss of one of the 3R-paralogs depends on the lineage: mtnr1ca was lost in euteleosts whereas mtnr1cb was lost in osteoglossomorphs and several ostariophysians including the zebrafish. We investigated the tissue distribution of mtnr expression in a large range of tissues in medaka. The medaka has conserved the four vertebrate paralogs, and these are expressed in brain and retina, and, differentially, in peripheral tissues. Photoperiod affects mtnr expression levels in a gene-specific and tissue-specific manner. This study provides new insights into the repertoire diversification and functional evolution of the mtnr gene family in vertebrates.

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